Paige, Adam - University of Bedfordshire - Department of Life Sciences

个人简介

I joined the School of Life Sciences in 2010 as Senior Lecturer in Biomedical Science. I studied chemistry and biochemistry at Imperial College, London (1990-1993) and then carried out a PhD in genetics at St Mary’s Hospital Medical School, London and the MRC Mouse Genome Centre, Harwell (1993-1997).

研究领域

Given my background both as a geneticist and as a cancer researcher, I am interested in investigating how the genes that normally prevent cancers from occurring can go wrong and lead to the growth of tumours. By understanding the biology of these genes and their function we can understand how different cancers behave, and how we might best treat cancer patients. I am particularly interested in understanding how some of these cancer genes affect the way our drugs work so that we might improve the treatments given to cancer patients.

近期论文

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Paige AJ; Zucknick M; Janczar S; Paul J; Mein CA; Taylor KJ; Stewart M; Gourley C; et al. (2010). WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis. Eur J Cancer. 46:818-825. Gourley C*; Paige AJ*; Taylor KJ; Ward C; Kuske B; Zhang J; Sun M; Janczar S; et al. (2009). WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3. Cancer Res. 69:4835-4842. Tan DSP; Lambros MBK; Rayter S; Natrajan R; Vatcheva R; Gao Q; Marchio C; Geyer FC; et al. (2009). PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas. Clin Cancer Res. 15:2269-2280. A. E. Alsop, K. Taylor, J. Zhang, H. Gabra, A. J.W. Paige, P. A.W. Edwards (2008) Homozygous Deletions May be Markers of Nearby Heterozygous Mutations: The Complex Deletion at FRA16D in the HCT116 Colon Cancer Cell Line Removes Exons of WWOX. Genes, Chromosomes and Cancer, 47 (5), p437. C. Gourley*, A. J. W. Paige*, K. J. Taylor, D. Scott, N-J. Francis, R. Rush, C. M. Aldaz, J.F. Smyth and H. Gabra (2005) Analysis of WWOX mRNA isoforms in ovarian cancer. International Journal of Oncology, 26 (6), p1681 Paige AJ; Taylor KJ; Taylor C; Hillier SG; Farrington S; Scott D; Porteous DJ; Smyth JF; et al. (2001). WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A. 98:11417-11422 Mburu P; Mustapha M; Varela A; Weil D; El-Amraoui A; Holme RH; Rump A; Hardisty RE; et al. (2003). Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Nat Genet. 34:421-428.