Padget, Kay - University of Northumbria -

个人简介

Upon completion of a BSc in Biomedical Science at Sunderland University, Dr Padget gained her PhD in Biochemistry at Newcastle University in 1998 and continued to pursue her research there until 2007 when she joined Northumbria University

研究领域

The role of DNA Topoisomerase II in macrophage maturation and as an immunological therapeutic target. Dr Padget's work is currently focused on establishing how Type II topoisomerases (topo II) facilitate transcription. In particular she is investigating whether changes in the transcriptome required for facilitating macrophage differentiation from monocyte precursors during the immune response are influenced by topo II. A better understanding of how topo II works in the immune response may identify possible new drugs for the treatment of immune disorders.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jaedicke KM, Roythorne A, Padget K, Todryk S, Preshaw PM, Taylor JJ. Leptin up-regulates TLR2 in human monocytes. (2013) J Leukoc Biol. Apr;93(4):561-71. Cowell IG, Sondka Z, Smith K, Lee KC, Manville CM, Sidorczuk-Lesthuruge M, Rance HA, Padget K, Jackson GH, Adachi N, Austin CA. Model for MLL translocations in therapy-related leukaemia involving topoisomerase IIbeta-mediated DNA strand breaks and gene proximity. (2012) Proc Natl Acad Sci U S A. 109(23):8989-94. Lee KC, Padget K, Curtis H, Cowell IG, Moiani D, Sondka Z, Morris N, Jackson G, Cockell S, Tainer J, Austin CA. MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. (2012) Biology Open 000:1-11. Cowell IG, Papageorgiou N, Padget K, Watters GP and Austin CA. Histone deacetylase inhibition redistributes topoisomerase II beta from heterochromatin to euchromatin - Implications for anti-cancer treatment. (2010). Nucleus 2: 1-11.