个人简介

ACS Fellow (2010) AAAS Fellow (2007) Appointed to UC Davis faculty (2001) Career Development Chair Award, Wayne State University (2000-01) Outstanding Scholarly Achievement Award, Wayne State University (2000) Associate Professor, Wayne State University (1999-2001) NSF CAREER Award (1997-2001) Arnold and Mabel Beckman Young Investigator Award (1996-98) Camille and Henry Dreyfus New Faculty Award (1994-99) Assistant Professor, Wayne State University (1994-99) Miller Research Fellowship, University of California, Berkeley (1992-94) Harold W. Dodds Honorific Fellowship, Princeton University (1990-91) CGP (Chemistry Graduate Program) Fellowship, Princeton University (1986-87) Ph.D. Princeton University (1992) M.A. Princeton University (1987) B.S. Peking (Beijing) University, P. R. China (1985)

研究领域

Analytical Chemistry/Materials Chemistry/Physical Chemistry

Professor Liu’s overall research objective focuses on the development of nanotechnology and potential applications to bioanalytical chemistry. One important aspect of the research is the design and engineering of nanostructures which position bioreceptors and chemical reaction sites on surfaces with high precision. The exquisite precision attainable by the nanolithographic methods developed allows complex multivalent interactions typical of biorecognition to be controlled, by varying the separation and local environment of the binding sites. Current projects include: (1) development of state-of-the-art imaging tools for high-resolution imaging of ligands, DNA, proteins and cells; (2) advanced methodologies for production of arrays of nanostructures; (3) single-cell imaging and mechanics; (4) using nanostructures of antibodies produced to investigate hypersensitivity reaction or allergy; (5) using nanostructures of ligands for study of the initial HIV infection of human T-cells; and (6) using nanostructures of ligands for the investigation of cancer cell signaling.

近期论文

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"Well-Defined, Size-Tunable, Multifunctional Micelles for Efficient Paclitaxel Delivery for Cancer Treatment" Luo, J.; Xiao, K.; Li,Y.; Lee, J. S.; Shi, L.; Tan, Y-H.; Li Xing, L.; Cheng, R. H.; Liu, G. Y.; Lam, K. S. Bioconjugate Chem. 2010, 21(7), 1216-1224. "High-Resolution Imaging of the Intramolecular Structure of Indomethacin-Carrying Dendrimers by Scanning Tunneling Microscopy" Fleming, C. J.; Yin, N. N.; Riechers, S. L.; Chu, G.; Liu, G. Y. ACS Nano 2011, 5(3), 1685-1692. "Hierarchical Micro- and Nanoscale Structures on Surfaces Produced Using a One-Step Pattern Transfer Process" Li, J. R.; Yin, N. N.; Liu, G. Y. J. Phys. Chem. Lett. 2011, 2, 289-294. "High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy" Shi, L. F.; Fleming, C. J.; Riechers, S. L.; Yin, N. N.; Luo, J.; Liu, G. Y. J. Drug. Delivery 2011, ID# 254095, 1-12. "Fabrication and Characterization of Rare-Earth-Doped Nanostructures on Surfaces" Mullen, T. J.; Zhang, M.; Feng, W.; El-Khouri, R. J.; Sun, L. d.; Yan, C. H.; Patten, T. E.; Liu, G. Y. ACS Nano. 2011, 5(8), 6539-6545. "Engineered Nanostructures of Antigen Provide an Effective Means for Regulating Mast Cell Activation" Deng, Z.; Weng, I-C.; Li, J-R.; Chen, H-Y.; Liu, F-T.; Liu, G. Y. ACS Nano 2011, 5(11), 8672-8683. "Two-Dimensional Crystallization of Hexagonal Bilayer with Moiré Patterns" Chen, Z. G.; Xu, Z. P.; Zhang, M.; Zhou, Y.; Liu, M.; Patten, T.; Liu, G.-Y.; Li, H.; Zeng, X. C.; Tan, L. J. Phys. Chem. B, 2012, 116 (14), pp 4363–4369. "Nanostructures of Designed Geometry and Functionality Enable Regulation of Cellular Signaling Processes" Li, J-R.; Shi, L.; Deng, Z.; Lo, S. H.; Liu, G. Y. Biochemistry, 2012, 51(30), 5876-5893. "F-Actin Reassembly during Focal Adhesion Impacts Single Cell Mechanics and Nanoscale Membrane Structure" Zimmer, C. C.; Shi, L.F.; Shih, Y.P.; Li, J-R; Jin, L;, Lo, S.H; Liu, G.Y. Science China, Chemistry, 2012, 55(9), 1922-1930. "Near-Field Scanning Optical Microscopy Enables Direct Observation of Moire Effects at the Nanometer Scale" Lin, W.F.; Li, J-R; Liu, G. Y. ACS Nano, 2012, 6(10), 9141-9149. "Receptor-mediated Transcytosis: A Mechanism for Active Extravascular Transport of Nanoparticles in Solid Tumors" Wei, l.; Xiong, C.; Zhang, R.; Shi, L. F.; Huang, M.; Zhang, G.; Song, S.; Huang, Q.; Liu, G. Y.; Li, C. Journal of Controlled Release, 2012, 161(3), 959-966. "Nanogratings of Fibronectin Provide an Effective Biochemical Cue for Regulating Focal Adhesion and Cellular Structure" Shi, L.F.; Li, J-R.; Shih, Y-P.; Lo, S. H; Liu, G. Y. Nano Research, 2012, 5(8), 565-575. "Improving Hematite's Solar Water Splitting Efficiency by Incorporating Rare-Earth Upconversion Nanomaterials" Zhang, M.; Lin, L.J.; Mullen, T. J.; Lin, W. F.; Sun, L. D.; Yan, C. H.; Patten, T. E.; Wang, D. W.; G. Y. J. Phys. Chem. Lett., 2012, 3(21), 3188-3192. "Particle Lithography Enables Fabrication of Multicomponent Nanostructures" Lin, W. F.; Swartz, L. A.; Li, J-R.; Liu, Y.; Liu, G. Y. J. Phys. Chem. C, 2013, 117(44), 23279-23285. "New Approach to Investigate the Cytotoxicity of Nanomaterials Using Single Cell Mechanics" Zimmer, C. C.; Liu, Y. X.; Morgan, J. T.; Yang, G.; Wang, K. H.; Kennedy, I. M.; Barakat, A. I.; Liu, G. Y. J. Phys. Chem. B, 2014, 118(5), 1246-1255. "In Situ and Real-Time Atomic Force Microscopy Studies of the Stability of Oligothiophene Langmuir-Blodgett Monolayers in Liquid" Yin, N. N.; Buyanin, A.; Riechers, Shawn L.; Lee, Olivia P.; Fréchet, J. M. J.; Salmeron, M.; Liu, G. Y. J. Phys. Chem. C, 2014, 118, 5789-5795. "Observation and Alteration of Surface States of Hematite Photoelectrodes" Du, C.; Zhang, M.; Jang, J. W.; Jang, L.; Liu, G. Y.; Wang, D. J. Phys. Chem. C, 2014, 118, 17054-17059. "Interaction Forces between Ternary Lipid Bilayers Containing Cholesterol" Kurniawan, J.; Yin, N. N.; Liu, G. Y.; Kuhl, T. L. Langmuir, 2014, 30, 4997-5004. "High-resolution Imaging of Polyethylene Glycol Coated Dendrimers via Combined Atomic Force and Scanning Tunneling Microscopy" Riechers, S.; Zhong, Q.; Yin, N-N.; Karsai, A.; da Rocha, S. R. P.; Liu, G. Y. Journal of Drug Delivery, 2015, Article ID 535683, 10 pages. "Engineering Amyloid Fibrils from β-Solenoid Proteins for Biomaterials Applications" Peralta, M. D. R.; Karsai, A.; Ngo, A.; Sierra, C.; Fong, K. T.; Hayre, N. R.; Mirzaee, N.; Ravikumar, K. M.; Kluber, A. J.; Chen, X., Liu, G. Y.; Toney, M. D.; Singh, R. R.; Cox, D. L. ACS Nano, 2015, 9, 449-463.