研究领域

Current research areas include: Bacterial resistance to antimicrobial metals. Gene regulation of antimicrobial metal resistance genes. Antimicrobial resistance plasmids and co-selection in Gram-negative bacteria. Laboratory and pathogenic Escherichia coli. Molecular methods for studying bacterial gene regulation and expression. Molecular methods for engineering Gram-negative bacteria.

Jon's research interests centre on bacterial metal ion homeostasis and resistance, and pathogenic enterobacteria.

近期论文

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ASIANI, K.R., WILLIAMS, H., BIRD, L., JENNER, M., SEARLE, M.S., HOBMAN, J.L., SCOTT, D.J. and SOULTANAS, P., 2016. SilE is an intrinsically disordered periplasmic ‘molecular sponge’ involved in bacterial silver resistance Molecular Microbiology. 101(5), 731-742 IBRAHIM, DELVEEN R., DODD, CHRISTINE E. R., STEKEL, DOV J., RAMSDEN, STEPHEN J. and HOBMAN, JON L., 2016. Multidrug resistant, extended spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm FEMS MICROBIOLOGY ECOLOGY. 92(4), BAKER, MICHELLE, HOBMAN, JON L., DODD, CHRISTINE E. R., RAMSDEN, STEPHEN J. and STEKEL, DOV J., 2016. Mathematical modelling of antimicrobial resistance in agricultural waste highlights importance of gene transfer rate FEMS MICROBIOLOGY ECOLOGY. 92(4), SAZINAS P, SMITH C, SUHAIMI A, HOBMAN JL, DODD CE and MILLARD AD, 2016. Draft Genome Sequence of the Bacteriophage vB_Eco_slurp01. Genome announcements. 4(6), SMITH R, O'HARA M, HOBMAN JL and MILLARD AD, 2016. Draft Genome Sequences of 14 Escherichia coli Phages Isolated from Cattle Slurry. Genome announcements. 3(6), HOBMAN J.L. and CROSSMAN L, 2015. Bacterial antimicrobial metal ion resistance. Journal of Medical Microbiology. 64, 471-497 TAKAHASHI H, OSHIMA T, HOBMAN JL, DOHERTY N, CLAYTON SR, IQBAL M, HILL PJ, TOBE T, OGASAWARA N, KANAYA S and STEKEL DJ, 2015. The dynamic balance of import and export of zinc in Escherichia coli suggests a heterogeneous population response to stress. Journal of the Royal Society, Interface / the Royal Society. 12(106), HAO X, LüTHJE FL, QIN Y, MCDEVITT SF, LUTAY N, HOBMAN JL, ASIANI K, SONCINI FC, GERMAN N, ZHANG S, ZHU Y and RENSING C, 2015. Survival in amoeba-a major selection pressure on the presence of bacterial copper and zinc resistance determinants? Identification of a "copper pathogenicity island". Applied microbiology and biotechnology. 99, 5817-5824 MONSIEURS, P., HOBMAN, J.L., VAN HOUDT, R., MERGEAY, M. and VANDENBUSSCHE, G., 2015. Response of Cupriavidus metallidurans CH34 to metals. In: MERGEAY, M. and VAN HOUDT, R., eds., Metal response in Cupriavidus metallidurans Volume I: from habitats to genes and proteins Springer. 45-89 BROWNING, D.F., WELLS, T.J., FRAN?A, F.L.S., MORRIS, F.C., SEVASTSYANOVICH, Y.R., BRYANT, J.A., JOHNSON, M.D., LUND, P.A., CUNNINGHAM, A.F., HOBMAN, J.L., MAY, R.C., WEBBER, M.A. and HENDERSON, I.R., 2013. Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis Molecular Microbiology. 87(5), 939-950 CHUMSUKAL, O., NAKAMURA, K., KURATA, T., SAKAMOTO, T., HOBMAN, J.L., OGASAWARA, N., OSHIMA, T. and ISHIKAWA, S., 2013. High-resolution mapping of in vivo genomic transcription factor binding sites using in situ DNase I footprinting and ChIP-seq DNA Research. 20(4), 325-338 HOBMAN J.L., JULIAN D.J. and BROWN N.L., 2012. Cysteine coordination of Pb(ii) is involved in the PbrR-dependent activation of the lead-resistance promoter, Ppbra, from Cupriavidus metallidurans CH34. BMC Microbiology. 12(1), 109 CLAYTON, S.R, HEURLIER, K, OSHIMA, T and HOBMAN, J.L., 2011. Copper and zinc stress in bacteria. In: KIDD, S.P., ed., Stress response in pathogenic bacteria Wallingford, CABI. 245-265 CARISS, S JAMES L, CONSTANTINIDOU, CHRYSTALA, PATEL, MALA D, TAKEBAYASHI, YUIKO, HOBMAN, JON L, PENN, CHARLES W and AVISON, MATTHEW B, 2010. YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli. Journal of Bacteriology. 192(13), 3329-36 CROSSMAN, L.C., CHAUDHURI, R.R., BEATSON, S.A., WELLS, T.J., DESVAUX, M., CUNNINGHAM, A.F., PETTY, N.K., MAHON, V., BRINKLEY, C., HOBMAN, J.L., SAVARINO, S.J., TURNER, S.M., PALLEN, M.J., PENN, C.W. and PARKHILL, J., 2010. A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407 Journal of Bacteriology. 192(21), 5822-5831 CHAUDHURI, R.R., SEBAIHIA, M., HOBMAN, J.L., WEBBER, M.A., LEYTON, D.L., GOLDBERG, M.D., CUNNINGHAM, A.F., SCOTT-TUCKER, A., FERGUSON, P.R., THOMAS, C.M., FRANKEL, G., TANG, C.M., DUDLEY, E.G., ROBERTS, I.S. and RASKO, D.A., 2010. Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS ONE. 5(1), e8801 BAILEY, A. M., CONSTANTINIDOU, C., IVENS, A., GARVEY, M.I., WEBBER, M.A., COLDHAM, N., HOBMAN, J.L., WAIN, J., WOODWARD, M.J. and PIDDOCK, L.J.V., 2009. Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification. The Journal of Antimicrobial Chemotherapy. 64(5), 973-85 MOEN,B., JANBU, A., LANGSRUD, S., LANGSRUD, ?., HOBMAN, J.L., CONSTANTINIDOU, C., KOHLER, A. and RUDI,K., 2009. Global responses of Escherichia coli to adverse conditions determined by microarrays and FT-IR spectroscopy. Canadian Journal of Microbiology. 55(6), 714-728 LEE, D.J., BINGLE, L.E.H., HEURLIER, K., PALLEN, M.J., PENN, C.W., BUSBY, S.J.W. and HOBMAN, J.L., 2009. Gene doctoring: a method for recombineering in laboratory and pathogenic Escherichia coli strains. BMC Microbiology. 9, 252 JULIAN, D.J., KERSHAW, C.J., BROWN, N. L. and HOBMAN, J. L., 2009. Transcriptional activation of MerR family promoters in Cupriavidus metallidurans CH34. Antonie van Leeuwenhoek. 96(2), 149-159 SCHUE, M, GLENDINNING, K, HOBMAN, J.L and BROWN, N.L., 2008. Evidence for direct interactions between the mercuric ion transporter (MerT) and mercuric reductase (MerA) from the Tn501 mer operon. Biometals. 21, 107-116 SILVER, S. and HOBMAN, J.L., 2007. Mercury microbiology: Environmental aspects, methylation and resistance systems.. In: DIETRICH H. NIES AND SIMON SILVER, ed., Molecular Microbiology of Heavy Metals Springer Verlag Microbial Monographs. 357-370 HOBMAN, J.L., PENN, C.W. and PALLEN, M.J., 2007. Laboratory strains of Escherichia coli: model citizens or deceitful delinquents growing old disgracefully? Molecular Microbiology. 64(4), 881-5 CARZANIGA, T, SARTI, D, TREVINO,V, MOOBED, S, BUCKLEY, C, SALMON, M, WILD, D, DEHO, G, CONSTANTINIDOU, C, HOBMAN, J. L and FALCIANI, F., 2007. Analysis of cellular transcriptional response at the genome level: two case studies with relevance to bacterial pathogenesis. In: FRANCESCO FALCIANI, ed., Microarray Technology Taylor and Francis, Oxford. 125-154 (In Press.) TREE, J.J, ULETT, G.C, HOBMAN, J.L, CONSTANTINIDOU, C, BROWN, N.L, KERSHAW, C.J, SCHEMBRI, M.A, JENNINGS, M.P and MCEWAN A.G., 2007. The multicopper oxidase (CueO) and cell aggregation in Escherichia coli. Environmental Microbiology. 9(8), 2110-6