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个人简介

Born: Wallasey, Wirral. Education: Wallasey and Marple Hall Grammar Schools; Pembroke College Oxford. Employment: Lister PostDoc, Univ Bristol (1981-82); Oppenheimer Postdoc, Univ Cambridge (1983-84); Supervisor (Queens College Cambridge 1984); Univ Nottingham (84-present). Visiting Prof: Friedrich Schiller Universität, Jena, (2009-2013). Awards: RSC Junior Medallist (1991); Oxford Univ DSc (2002); Ridder Første (Norway), 2011. Video DSc award; Video Norwegian award; 2016 Hakon Hakonsson Lecture; Wikipedia Norway - people from Wirral.

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HARDING, S.E., 2017. Felix Franks 1926-2016 Royal Society of Chemistry. Biotechnology Group Newsletter. (January), 2-3 ALZAHRANI, Q.E., ADAMS, G.G., GILLIS, R.B., BESONG, T.M.D., KOK, M.S., FONG, E., HARDING, R.A., VAN DAM, J.E.G., GOSSELINK, R.J.A., ROWE, A.J. and HARDING, S.E., 2016. Matrix-free hydrodynamic study on the size distribution and conformation of three technical lignins from wood and non-wood Holzforschung. 70, 117-125 HARDING, S.E., 2016. Did the Vikings use crystal ‘sunstones’ to discover America? The Conversation. 53836 HARDING SE, ADAMS GG and GILLIS RB, 2016. Molecular weight analysis of starches: which technique? Starch/St?rke. 68, 1-8 ABDELHAMEED, A.S., ADAMS, G.G., MORRIS, G.A., ALMUTAIRI, F.M., DUVIVIER, P., CONRATH, K. and HARDING, S.E., 2016. A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate. Nature Scientific Reports. 6, 22208 ALMUTAIRI, F.M., HERNANDEZ-CIFRE, J.G., ADAMS, G.G., KOK, M.S., MACKIE, A.R., GARCIA DE LA TORRE, J. and HARDING, S.E., 2016. Application of recent advances in hydrodynamic methods for characterising mucins in solution European Biophysics Journal. 45(1), 45-54 HUSSAIN R, HARDING SE, HUGHES CS, MA P, PATCHING SG, EDARA S, SILIGARDI G, HENDERSON PJ and PHILLIPS-JONES MK, 2016. Purification of bacterial membrane sensor kinases and biophysical methods for determination of their ligand and inhibitor interactions. Biochemical Society Transactions. 44(3), 810-23 GILLIS RB, ADAMS GG, ALZAHRANI Q and HARDING SE, 2016. A novel analytical ultracentrifugation based approach to the low resolution structure of gum arabic. Biopolymers. 105(9), 618-25 MACKIE AR, MACIERZANKA A, AARAK K, RIGBY NM, PARKER R, CHANNELL GA, HARDING SE and BAJKA BH, 2016. Sodium alginate decreases the permeability of intestinal mucus. Food Hydrocolloids. 52, 749-755 VARZAKAS T, ALGHAMDI A, ALGHAMDI H, LINFORTH R, DINU V, BESONG TD, GILLIS RB, ADAMS GG, ARAPOGLOU D, CONNERTON IF, HARDING SE and ISRAILIDES C, 2016. The effect of thermal processing in oil on the macromolecular integrity and acrylamide formation from starch of three potato cultivars organically fertilized Cogent Food & Agriculture. 2, 1180950 PATEL TR, NIKODEMUS D, BESONG TMD, REUTEN R, MEIER M, HARDING SE, WINZOR DJ, KOCH M and STETEFELD J, 2016. Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction Matrix Biology. 49, 93-105 HARDING SE, ADAMS GG, GILLIS RB, ALMUTAIRI FM and MORRIS GA, 2016. Aspects of the Analytical Ultracentrifuge Determination of the Molar Mass Distribution of Polysaccharides. In: UCHIYAMA S, ARISAWA F, STAFFORD WF, LAUE T, ed., Analytical Ultracentrifugation: Instrumentation, Software, and Applications Springer Verlag. 375-386 SWEENEY, SM, BULLEN, GA, GILLIS, RB, ADAMS, GG, ROWE, AJ, HARDING, SE, TUCKER, JHR, PEACOCK, AFA and MURPHY, PV, 2016. Coiled coil type neoglycoproteins presenting three lactose residues TETRAHEDRON LETTERS. 57(13), 1414-1417 ULUISIK, S., CHAPMAN, N.H., SMITH, R., POOLE, M., ADAMS, G., GILLIS, R.B., BESONG, T.M.D., SHELDON, J., STIEGELMEYER, S., PEREZ, L., SAMSULRIZAL, N., WANG, D., FISK, I.D., YANG, N., BAXTER, C., RICKETT, D., FRAY, R., BLANCO-ULATE, B., POWELL, A.L.T., HARDING, S.E., CRAIGON, J., ROSE, J.K.C., FICH, E.A., SUN, L., DOMOZYCH, D.S., FRASER, P.D., TUCKER, G.A., GRIERSON, D. and SEYMOUR, G.B., 2016. Genetic improvement of tomato by targeted control of fruit softening Nature Biotechnology. 34(9), doi:10.1038/nbt.3602 HORNIBLOW, RD, LATUNDE-DADA, GO, HARDING, SE, SCHNEIDER, M, ALMUTAIRI, FM, SAHNI, M, BHATTI, A, LUDWIG, C, NORTON, IT, IQBAL, TH and TSELEPIS, C, 2016. The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health. Molecular Nutrition & Food Research. 60(9), 2098-108 SARANGAPANI PS, WEAVER J, PARUPUDI A, BESONG TM, ADAMS GG, HARDING SE, MANIKWAR P, CASTELLANOS MM, BISHOP SM and PATHAK JA, 2016. Both Reversible Self-Association and Structural Changes Underpin Molecular Viscoelasticity of mAb Solutions. Journal of Pharmaceutical Sciences. 105(12), 3496-3506 ABDELHAMEED AS, MORRIS GA, ALMUTAIRI F, ADAMS GG, DUVIVIER P, CONRATH K and HARDING SE, 2016. Solution conformation and flexibility of capsular polysaccharides from Neisseria meningitidis and glycoconjugates with the tetanus toxoid protein. Nature Scientific reports. 6, 35588 ULUISIK S, CHAPMAN NH, SMITH R, POOLE M, ADAMS G, GILLIS RB, BESONG TM, SHELDON J, STIEGELMEYER S, PEREZ L, SAMSULRIZAL N, WANG D, FISK ID, YANG N, BAXTER C, RICKETT D, FRAY R, BLANCO-ULATE B, POWELL AL, HARDING SE, CRAIGON J, ROSE JK, FICH EA, SUN L, DOMOZYCH DS, FRASER PD, TUCKER GA, GRIERSON D and SEYMOUR GB, 2016. Corrigendum: Genetic improvement of tomato by targeted control of fruit softening. Nature biotechnology. 34(10), 1072 GILLIS RB, ROWE AJ, ADAMS GG and HARDING SE, 2015. A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in Biotechnology. Biotechnology & Genetic Engineering Reviews. 30, 142-157 HARDING SE, GILLIS RB, ALMUTAIRI F, ERTEN T, K?K M? and ADAMS GG, 2015. Recent advances in the analysis of macromolecular interactions using the matrix-free method of sedimentation in the analytical ultracentrifuge. Biology. 4(1), 237-50 ZHAO H, GHIRLANDO R, ALFONSO C, ARISAKA F, ATTALI I, BAIN DL, BAKHTINA MM, BECKER DF, BEDWELL GJ, BEKDEMIR A, BESONG TMD, BIRCK C, BRAUTIGAM CA, BRENNERMAN W, BYRON O, BZOWSKA A, CHAIRES JB, CHATON CT, C?LFEN H, CONNAGHAN KD, CROWLEY KA, CURTH U, DAVITER T, DEAN WL, DíEZ AI, EBEL C, ECKERT DM, EISELE LE, EISENSTEIN E, ENGLAND P, ESCALANTE C, FAGAN JA, FAIRMAN R, FINN RM, FISCHLE W, DE LA TORRE JG, GOR J, GUSTAFSSON H, HALL D, HARDING SE, CIFRE JGH, HERR AB, HOWELL EE, ISAAC RS, JAO S, JOSE D, KIM S, KOKONA B, KORNBLATT JA, KOSEK D, KRAYUKHINA E, KRZIZIKE D, KUSZNIR EA, KWON H, LARSON A, LAUE TM, LE ROY A, LEECH AP, LILIE H, LUGER K, LUQUE-ORTEGA JR, MA J, MAY CA, MAYNARD EL, MODRAK-WOJCIK A, MOK Y, MüCKE N, NAGEL-STEGER L, NARLIKAR GJ, NODA M, NOURSE A, OBSIL T, PARK CK, PARK J, PAWELEK PD, PERDUE EE, PERKINS SJ, PERUGINI MA, PETERSON CL, PEVERELLI MG, PISZCZEK G, PRAG G, PREVELIGE PE, RAYNAL BDE, REZABKOVA L, RICHTER K, RINGEL AE, ROSENBERG R, ROWE AJ, RUFER AC, SCOTT DJ, SERAVALLI JG, SOLOVYOVA AS, SONG R, STAUNTON D, STODDARD C, STOTT K, STRAUSS HM, STREICHER WW, SUMIDA JP, SWYGERT SG, SZCZEPANOWSKI RH, TESSMER I, TOTH RT, TRIPATHY A, UCHIYAMA S, UEBEL SFW, UNZAI S, GRUBER AV, VON HIPPEL PH, WANDREY C, WANG S, WEITZEL SE, WIELGUS-KUTROWSKA B, WOLBERGER C, WOLFF M, WRIGHT E, WU Y, WUBBEN JM and SCHUCK P, 2015. A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLOS ONE. 10(5), e0126420 ALMUTAIRI, F.M., ERTEN, T., ADAMS, G.G., HAYES, M., MCLOUGHLIN, P., KOK, M.S., MACKIE, A.R., ROWE, A.J. and HARDING, S.E., 2015. Hydrodynamic characterisation of chitosan and its interaction with two polyanions: DNA and xanthan Carbohydrate Polymers. 122, 359-366 HARDING, S.E., ADAMS, G.G., ALMUTAIRI, F., ALZAHRANI, Q., ERTEN, T., K?K, M.S. and GILLIS, R.B, 2015. Ultracentrifuge methods for the analysis of polysaccharides, glycoconjugates, and lignins. Methods in Enzymology. 562, 391-439 SCOTT, D.J., HARDING, S.E. and WINZOR, D.J., 2015. Evaluation of diffusion coefficients by means of an approximate steady-state condition in sedimentation velocity distributions Analytical Biochemistry. 490, 20-25 SCHUCK, P., GILLIS, R.B., BESONG, D., ALMUTAIRI, F.M., ADAMS, G.G., ROWE, A.J. and HARDING, S.E., 2014. SEDFIT-MSTAR: Molecular weight and molecular weight distribution analysis of polymers by sedimentation equilibrium in the ultracentrifuge. Analyst. 139, 79-92

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