个人简介

Appointed to UC Davis faculty (1989) UC President's Fellow, UC Irvine (1988-89) NATO-NSF Postdoctoral Fellow, Technical University, Berlin (1986-87) Alexander von Humboldt Postdoctoral Fellow, Technical University, Berlin (1985-86) Ph.D. University of California, Berkeley (1985) B.S. University of California, Irvine (1981)

研究领域

Research in the group is focused on analytical chemistry with specific emphasis in the area of nutrition, disease markers, and mass spectrometric methods. Our area of study is as diverse as the students who take part. Students come from all disciplines of chemistry including analytical, physical, organic, and biological, as well as from other departments including engineering and food science. Our expertise in oligosaccharides and glycosylation of proteins and lipids make our group unique. Our efforts in science are also broad, encompassing instrument construction and development to investigating biological problems. This broad-based approach provides us with unique perspectives that we employ to our specific scientific problems.

The focus of the group is in the development of analytical tools based on advanced separation and mass spectrometry in two areas—nutrition and diseases. We are developing mass spectrometry based tools for the discovery of markers for cancer including ovarian, breast, and prostate. We are pioneering the glycomic approach for the early diagnosis of cancer. In nutrition we are examining human milk as the model for the perfect food and determining bioactive components in milk.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

M R Charbonneau, L V Blanton, D B DiGiulio, D A Relman, C B Lebrilla, D A Mills, J I Gordon A microbial perspective of human developmental biology. Nature 2016, 535, 48-55. D Park, N Arabyan, CC Williams, T Song, A Mitra, BC Weimer, CB Lebrilla Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion. Molecular and Cellular Proteomics 2016, 15, 3653-3664. MJ Kailemia, D Park, CB Lebrilla Glycans and glycoproteins as specific biomarkers for cancer. Analytical and Bioanalytical Chemistry 2016, 409, 295-410. D Park, N Arabyan, CC Williams, T Song, A Mitra, BC Weimer, CB Lebrilla Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion. Molecular and Cellular Proteomics 2016 15, 3653-3664. J CC Davis, S M Totten, J O Huang, S Nagshbandi, N Kirmiz, D A G, Z T Lewis, Lauren D Wu, Jennifer T Smilowitz, J Bruce German, David A Mills, Carlito B Lebrilla Identification of Oligosaccharides in feces of breast-fed infants and their correlation with the gut microbial community. Molecular & Cellular Proteomics 2016 15, 2987-3002. MR Charbonneau, D O’Donnell, LV Blanton, SM Totten, JCC Davis, MJ Barratt, J Cheng, J Guruge, M Talcott, J R Bain, M J Muehlbauer, O Ilkayeva, C Wu, T Struckmeyer, D Barile, C Mangani, J Jorgensen, YM Fan, K Maleta, K G Dewey, P Ashorn, C B Newgard, CB Lebrilla, D A Mills, J I Gordon Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell 2016 164, 859-871 LR Ruhaak, K Kim, C Stroble, SL Taylor, Q Hong, S Miyamoto, CB Lebrilla, G Leiserowitz Protein-specific differential Glycosylation of Immunoglobulins in serum of Ovarian Cancer Patients. Journal Proteome Research 2016 15, 1002-1010. Li B., H.J. An, J.L. Hedrick, and C.B. Lebrilla. Infrared multiphoton dissociation mass spectrometry for structural elucidation of oligosaccharides. Methods in Molecular Biology 2009. 534:23-35. Li B., H.J. An, J.L. Hedrick, and C.B. Lebrilla. Collision-induced dissociation tandem mass spectrometry for structural elucidation of glycans. Methods in Molecular Biology 2009. 534:133-145. Cooke C.L., H.J. An, J. Kim, D.R. Canfield, J. Torres, C.B. Lebrilla, and J.V. Solnick. Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology 2009. 137:1061-1071. Tao N., E.J. DePeters, J.B. German, R. Grimm, and C.B. Lebrilla. Variations in bovine milk oligosaccharides during early and middle lactation stages analyzed by HPLC-Chip/mass spectrometry. Journal of Dairy Science, 2009. 92:2991-3001. Dodds E.D., F. Tassone, P.J. Hagerman, and C.B. Lebrilla. Polymerase chain reaction, nuclease digestion, and mass spectrometry based assay for the trinucleotide repeat status of the Fragile X mental retardation 1 gene. Analytical Chemistry, 2009. 81:5533-40. Barkauskas D.A., S.R. Kronewitter, C.B. Lebrilla, and D.M. Rocke. Analysis of MALDI FT-ICR mass spectrometry data: A time series approach. Children's Oncology Group, Arcadia, CA, USA. Department of Chemistry, University of California, Davis, CA, USA. Division of Biostatistics, School of Medicine, University of California, Davis, CA, USA. Analytica Chimica Acta 2009. 648:207-214. An H.J. and C.B. Lebrilla. Profiling of glycome: A glycomics approach for the discovery of potential cancer biomarkers. Methods in Molecular Biology: Functional Glycomics, 2009. in press. An H.J., J.W. Froehlich, C.B. Lebrilla. Determination of glycosylation sites and site-specific heterogeneity in glycoproteins. Current Opinion in Chemical Biology 5, in press. Barile D., N. Tao, C.B. Lebrilla, J.D. Coissonc, M. Arlorioc and J.B. German. Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides. 2009. International Dairy Journal 19:524-530. Ninonuevo M.R. and C.B. Lebrilla. Mass spectrometric methods for oligosaccharides analysis in human milk: Developments and applications. Nutrition Reviews, in press. An H.J., S.R. Kronewitter, M.L.A. de Leoz, and C.B. Lebrilla. Glycomics and disease markers. Current Opinion in Chemical Biology, 2009. in press.