Fray, Rupert - University of Nottingham

研究领域

Rupert's main research interest is the study of messenger RNA (mRNA) methylation in plants and other eukaryotes. His group studies the enzymes involved in the synthesis of N6 methyladenosine, the mRNAs that are targeted for methylation, the consequences of this methylation and the proteins that recognise the modified nucleotide. He also has a long standing interest in synthetic biology approaches to crop improvement with research areas including the manipulation of plant-microbe interactions through "quorum sensing", chloroplast transformation systems and the production of taxanes in heterologous plant systems.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

BARTON, N.A., MARSH, B.J., LEWIS, W., NARRAIDOO, N., SEYMOUR, G.B., FRAY, R.G. and HAYES, C.J., 2016. Accessing low-oxidation state taxanes: Is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway Chemical Science. ULUISIK, S., CHAPMAN, N., SMITH, R., POOLE, M., ADAMS, G., GILLIS, R.B., BESONG, T.M.D., SHELDON, J., STIEGELMEYER, S., PEREZ, L., FISK, I.D., YANG, N., BAXTER, C., RICKETT, D., FRAY, R., BLANCO-ULATE, B., POWELL, A.L.T., HARDING, S.E., CRAIGON, J., ROSE, J.K.C., FICH, E., SUN, L., DOMOZYCH, D.S., FRASER, P.D., TUCKER, G.A., GRIERSON, D. and SEYMOUR, G.B., 2016. Genetic improvement of tomato by selective control of fruit softening. Nature Biotechnology. (in press) HAUSSMANN IU, BODI Z, SANCHEZ-MORAN E, MONGAN NP, ARCHER N, FRAY RG and SOLLER M, 2016. m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature. 540(7632), 301-304 CHENG F, MA A, ZHUANG G and FRAY RG, 2016. Exogenous N-acyl-homoserine lactones enhance the expression of flagella of Pseudomonas syringae and activate defence responses in plants. Molecular plant pathology. (In Press.) CHEW BL, FISK ID, FRAY R, TUCKER GA, BODI Z, FERGUSON A, XIA W and SEYMOUR GB, 2016. The effect of adenosine monophosphate deaminase overexpression on the accumulation of umami-related metabolites in tomatoes. Plant cell reports. (In Press.) BODI, ZSUZSANNA, BOTTLEY, ANDREW, ARCHER, NATHAN, MAY, SEAN T and FRAY, RUPERT G, 2015. Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment. PloS one. 10(7), e0132090 FRAY RG and SIMPSON GG, 2015. The Arabidopsis epitranscriptome. Current opinion in plant biology. 27, 17-21 PAN Y, BRADLEY G, PYKE K, BALL G, LU C, FRAY R, MARSHAL A, AYASUTA S, BAXTER C, WIJK R V, BOYDEN L, CADE R, CHAPMAN NH, FRASER PD, HODGMAN C and SEYMOUR G, 2014. Network Inference Analysis Identifies an APRR2-Like Gene Linked to Pigment Accumulation in Tomato and Pepper Fruits Plant Physiology. 161, 1476-1485 BODI, Z., ARCHER, N., PEPLOE, C., GRIFFIN-BOOTH, L., KING, D., KAHKA, G. and FRAY, R., 2014. N6 adenosine methylation of mRNA - an expanding role Biotechnologia (Poznan). 95(1), 57 BODI Z, ZHONG S, MEHRA S, SONG J, GRAHAM N, LI H, MAY S and FRAY RG, 2012. Adenosine methylation in Arabidopsis mRNA is associated with the 3’ end and reduced levels cause developmental defects Frontiers in Plant Science. 3, 48 ó LOCHLAINN S, FRAY RG, HAMMOND JP, KING GJ, WHITE PJ, YOUNG SD and BROADLEY MR, 2011. Generation of nonvernal-obligate, faster-cycling Noccaea caerulescens lines through fast neutron mutagenesis New Phytologist. 189, 409-414 ó LOCHLAINN S, BOWEN HC, FRAY RG, HAMMOND JP, KING GJ, WHITE PJ, GRAHAM NS and BROADLEY MR, 2011. Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator Noccaea caerulescens PloS ONE. 6, 3 KRUSE, S., ZHONG, S., BODI, Z., BUTTON, J., ALCOCER, M.J.C., HAYES, C.J. and FRAY, R., 2011. A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA Scientific Reports. 1, 126 BODI, Z., BUTTON, J.D., GRIERSON, D. and FRAY, R.G., 2010. Yeast targets for mRNA methylation. Nucleic Acids Research. 38(16), 5327-5335 KATALIN KOVáCS, PHILIP J. HILL, DONALD GRIERSON, CHRISTINE E.R. DODD, DORU PAMFIL, RUPERT G. FRAY., 2009. Development of a novel inducible bioluminescent and antibiotic resistance tagging system and its use to investigate the role of antibiotic production by Pectobacterium carotovorum ssp. carotovorum during potato tuber infection European Journal of Plant Pathology. 125(4), 655-664 KOVACS, KATALIN, FRAY, RUPERT G., TIKUNOV, YURY, GRAHAM, NEIL, BRADLEY, GLYN, SEYMOUR, GRAHAM B., BOVY, ARNAUD G. and GRIERSON, DONALD, 2009. Effect of tomato pleiotropic ripening mutations on flavour volatile biosynthesis PHYTOCHEMISTRY. 70(8), 1003-1008 BROADLEY, M.R., WHITE, P.J., HAMMOND, J.P., GRAHAM, N.S., BOWEN, H.C., EMMERSON, Z.F., FRAY, R.G., IANNETTA, P.P.M., MCNICOL, J.W. and MAY, S.T., 2008. Evidence of neutral transcriptome evolution in plants New Phytologist. 180(3), 587-593 JAFFé, B., KOVáCS, K., ANDRAS, C., BóDI, Z., LIU, Z. and FRAY, R.G., 2008. Methylation of chloroplast DNA does not affect viability and maternal inheritance in tobacco and may provide a strategy towards transgene containment Plant Cell Reports. 27(8), 1377-1384 ZHONG, S, LI, H, BODI, Z, BUTTON, J, VESPA, L, HERZOG, M and FRAY, R.G., 2008. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor Plant Cell. 20(5), 1278-1288 BARRIUSO, J., RAMOS SOLANO, B., FRAY, R.G., CáMARA, M., HARTMANN, A. and GUTIéRREZ MA?ERO, F.J., 2008. Transgenic tomato plants alter quorum sensing in plant growth-promoting rhizobacteria Plant Biotechnology Journal. 6(5), 442-452 KOVACS, K., ZHANG, L., LINFORTH, R.S.T., WHITTAKER, B., HAYES, C.J. and FRAY, R.G., 2007. Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit. Transgenic Research. 16(1), 121-6 SCOTT, R.A., WEIL, J., LE, P.T., WILLIAMS, P., FRAY, R.G., VON BODMAN, S.B. and SAVKA, M.A., 2006. Long- and short-chain plant-produced bacterial N-acyl-homoserine lactones become components of phyllosphere, rhizosphere, and soil Molecular Plant-Microbe Interactions. 19(3), 227-39 TOTH, I.K., NEWTON, J.A., HYMAN, L.J., LEES, A.K., DAYKIN, M., ORTORI, C., WILLIAMS, P. and FRAY, R.G., 2004. Potato plants genetically modified to produce N-acylhomoserine lactones increase susceptibility to soft rot erwiniae Molecular Plant-Microbe Interactions. 17(8), 880-887 WATERS, M.T., FRAY, R.G. and PYKE, K.A., 2004. Stromule formation is dependent upon plastid size, plastid differentiation status and the density of plastids within the cell Plant Journal. 39(4), 655-667 D'ANGELO-PICARD, C., FAURE, D., CARLIER, A., UROZ, S., RAFFOUX, A., FRAY, R. and DESSAUX, Y., 2004. Bacterial populations in the rhizosphere of tobacco plants producing the quorum-sensing signals hexanoyl-homoserine lactone and 3-oxo-hexanoyl-homoserine lactone FEMS Microbiology Ecology. 51(1), 19-29