研究领域

Unravelling the mechanism through which maternal obesity and maternal age increases the risk of dysfunctional labour and emergency caesarean section The effects of dietary polyunsaturated fatty acids on prostaglandin production and the timing of labour. The effects of maternal protein restriction on the adult onset of cardiovascular disease in the offspring.

Other research interests include the effects of maternal obesity and maternal age on pregnancy and labour outcome. Epidemiological evidence suggests that maternal obesity and increasing maternal age are associated with uncoordinated myometrial contractions, prolonged labour and increased risk of caesarean section. The immediate aim is to elucidate the mechanism behind dysfunctional labour in these individuals to ultimately identify biomarkers for mothers at risk of dysfunctional labour or intervention to reduce or even prevent the risk of caesarean section which is not ideal for the health and wellbeing of the mother and newborn child and a huge cost to the NHS.

近期论文

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RONAN MUIR, JEAN BALLAN, BETHAN CLIFFORD, SARAH MCMULLEN, RAHEELA KHAN, ANATOLY SHMYGOL, SIOBHAN QUENBY and MATTHEW ELMES, 2016. Modelling maternal obesity: The effects of a chronic high–fat, high-cholesterol diet on uterine expression of contractile associated proteins and ex-vivo contractile activity during labour in the rat.: Obesity and uterine contractile activity during labour Clinical Science. 130 CLINT GRAY, SHEILA GARDNER, MATTHEW ELMES and DAVID GARDNER, 2016. Excess maternal salt or fructose intake programs sex-specific, stress- and fructose-sensitive hypertension in the offspring.: Programming of sex-specific hypertension British Journal of Nutrition. 115(4), 594-604 ELMES, MATTHEW, SZYSZKA, ALEXANDRA, PAULIAT, CAROLINE, CLIFFORD, BETHAN, DANIEL, ZOE, CHENG, ZHANGRUI, WATHES, CLAIRE and MCMULLEN, SARAH, 2015. Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat. Physiological reports. 3(4), pii: e12305. ZHANGRUI CHENG,, ROBERT D ABAYASEKARA, MATTHEW ELMES,, SUE KIRKUP and CLAIRE D WATHES, 2015. Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes Placenta,. 36(9), 1011-7 RYAN K, ELMES MJ and LANGLEY-EVANS SC, 2012. The effects of prenatal protein restriction on ß-adrenergic signalling of the adult rat heart during ischaemia reperfusion. Journal of Nutrition and Metabolism. 2012, 397389 CHENG, Z, ELMES, M, KIRKUP, S, ABAYASEKARA, D R E and WATHES, D C, 2011. Effects of n-6 polyunsaturated fatty acids on prostaglandin production in ovine fetal chorion cells in vitro in late gestation ewes. Placenta. ELMES, M.J., TAN, D.S.-Y., CHENG, Z., WATHES, D.C. and MCMULLEN, S., 2011. The effects of a high-fat, high-cholesterol diet on markers of uterine contractility during parturition in the rat Reproduction: The Journal of the Society for Reproduction and Fertility. 141(2), 283-290 KIRKUP, S.E., CHENG, Z., ELMES, M., WATHES, D.C. and ABAYASEKARA, D.R.E., 2010. Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro Reproduction: The Journal of the Society for Reproduction and Fertility. 140(6), 943-951 ELMES, M.J., HAASE, A., GARDNER, D.S. and LANGLEY-EVANS, SC., 2009. Sex differences in sensitivity to β-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction British Journal of Nutrition. 101(5), 725-734 ELMES, M.J., MCMULLEN, S., GARDNER, D.S. and LANGLEY-EVANS, S.C., 2008. Prenatal diet determines susceptibility to cardiac ischaemia-reperfusion injury following treatment with diethylmaleic acid and N-acetylcysteine Life Sciences. 82(3-4), 149-155 ELMES, MATTHEW J, GARDNER, DAVID S and LANGLEY-EVANS, SIMON C, 2007. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury. British Journal of Nutrition. 98(1), 93-100 ELMES, M, GREEN, L R, POORE, K, NEWMAN, J, BURRAGE, D, ABAYASEKARA, D R E, CHENG, Z, HANSON, M A and WATHES, D C, 2005. Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology. 562(Pt 2), 583-92 CHENG, Z, ELMES, M, KIRKUP, S E, CHIN, E C, ABAYASEKARA, D R E and WATHES, D C, 2005. The effect of a diet supplemented with the n-6 polyunsaturated fatty acid linoleic acid on prostaglandin production in early- and late-pregnant ewes. Journal of Endocrinology. 184(1), 165-78 ELMES, MATTHEW, TEW, PRIYA, CHENG, ZHANGRUI, KIRKUP, SUE E, ABAYASEKARA, D ROBERT E, CALDER, PHILIP C, HANSON, MARK A, WATHES, D CLAIRE and BURDGE, GRAHAM C, 2004. The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. Biochimica et Biophysica Acta. 1686(1-2), 139-47 CHENG, Z, ELMES, M, KIRKUP, S E, ABAYASEKARA, D R E and WATHES, D C, 2004. Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. Journal of Endocrinology. 182(2), 249-56 MOSTYN, A., PEARCE, S., BUDGE, H., ELMES, M., FORHEAD, A. J., FOWDEN, A. L., STEPHENSON, T. and SYMONDS, M. E., 2003. Influence of cortisol on adipose tissue development in the fetal sheep during late gestation Journal of Endocrinology. 176(1), 23-30 CHENG, Z, ELMES, M, ABAYASEKARA, D R E and WATHES, D C, 2003. Effects of conjugated linoleic acid on prostaglandins produced by cells isolated from maternal intercotyledonary endometrium, fetal allantochorion and amnion in late pregnant ewes. Biochimica et Biophysica Acta. 1633(3), 170-8 WATHES, CD, CHENG, ZR, ELMES, M, KIRKUP, SE and ABAYASEKARA, RE, The effect of n-6 polyunsaturated fatty acids (PUFAS) on prostaglandin production by the endometrium of late pregnant ewes. In: 340-340