Stephens, Gill - University of Nottingham - Department of Chemical and Environmental Engineering

个人简介

Gill's main research interest is in using cells and enzymes as biocatalysts to manufacture chemicals. Gill graduated with a BSc in Biochemistry from the University of Kent, and a PhD on microbial metabolism from the University of Warwick. She did postdoctoral research on the acetone-butanol fermentation with Professor Gareth Morris FRS at the University College of Wales, Aberystwyth, and then she worked on oxygenase-catalysed biotransformations with Professor Sir Howard Dalton FRS, at the University of Warwick. Gill then joined the Department of Chemical Engineering, UMIST in 1988 (now part of the University of Manchester), and established a research group working on biotransformations using anaerobic bacteria. She was seconded for 3 years as Research Director of Pro-Bio Faraday Partnership from 2001-4. She joined the University of Nottingham in 2010 as Chair of Bioprocessing and BBSRC Research Development Fellow.

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ESHTAYA, M., EJIGU, A., STEPHENS, G., WALSH, D. A., CHEN, G. Z.* and CROFT, A. K.*, 2016. Developing energy efficient lignin biomass processing – Towards understanding mediator behaviour in ionic liquids FARADAY DISCUSSIONS: Liquid Salts for Energy and Materials. 190, 127-145 ROSSONI, L., HALL, S. J., EASTHAM, G., LICENCE, P. and STEPHENS, G., 2015. The Putative Mevalonate Diphosphate Decarboxylase from Picrophilus torridus Is in Reality a Mevalonate-3-Kinase with High Potential for Bioproduction of Isobutene: Applied and Environmental Microbiology Applied and Environmental Microbiology. 81(7), 2625-2634 SELLICK, C. A., CROXFORD, A. S., MAQSOOD, A. R., STEPHENS, G. M., WESTERHOFF, H. V., GOODACRE, R. and DICKSON, A. J., 2015. Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness: Biotechnology Journal Biotechnology Journal. 10(9), 1434-1445 GR EASTHAM, DW JOHNSON, I ARCHER, R CARR, J WEBB and G STEPHENS, 2015. A Process for Production of Methacrylic Acid and Derivatives Thereof WO2015022496 02/19/2015 00:00:00 REHMANN, L; IVANOVA, E; GUNARATNE, HQN; SEDDON, KR; STEPHENS, G, 2014. Enhanced laccase stability through mediator partitioning into hydrophobic ionic liquids Green Chemistry. 16(3), 1462-1469 ASHTON L., XU Y., BREWSTER V.L., COWCHER D.P., SELLICK C.A., DICKSON A.J., STEPHENS G.M., GOODACRE R., 2013. The challenge of applying Raman spectroscopy to monitor recombinant antibody production Analyst. 6977-85 REHMANN, LARS, IVANOVA, EKATERINA, FERGUSON, JAMIE L., GUNARATNE, H. Q. NIMAL, SEDDON, KENNETH R. and STEPHENS, GILLIAN M., 2012. Measuring the effect of ionic liquids on laccase activity using a simple, parallel method Green Chemistry. 14(3), 725-733 SOTENKO M.V., REBROS M., SANS V.S., LOPONOV K.N., DAVIDSON M.G., STEPHENS G., LAPKIN A.A., 2012. Tandem transformation of glycerol to esters Journal of Biotechnology. 162(4), 390–397 FRYSZKOWSKA A., TOOGOOD H.S., MANSELL D., STEPHENS G., GARDINER J.M., SCRUTTON N.S., 2012. A surprising observation that oxygen can affect the product enantiopurity of an enzyme-catalysed reaction FEBS Journal. 279, 4160-71 FRYSZKOWSKA, ANNA, TOOGOOD, HELEN, SAKUMA, MICHIYO, STEPHENS, GILL M., GARDINER, JOHN M. and SCRUTTON, NIGEL S., 2011. Active site modifications in pentaerythritol tetranitrate reductase can lead to improved product enantiopurity, decreased by-product formation and altered stereochemical outcome in reactions with alpha,beta-unsaturated nitroolefins Catalysis Science & Technology. 1(6), 948-957 SELLICK, CHRISTOPHER A., CROXFORD, ALEXANDRA S., MAQSOOD, ARFA R., STEPHENS, GILL, WESTERHOFF, HANS V., GOODACRE, ROYSTON and DICKSON, ALAN J., 2011. Metabolite Profiling of Recombinant CHO Cells: Designing Tailored Feeding Regimes That Enhance Recombinant Antibody Production Biotechnology and Bioengineering. 108(12), 3025-3031 SELLICK, CHRISTOPHER A., HANSEN, RASMUS, STEPHENS, GILL M., GOODACRE, ROYSTON and DICKSON, ALAN J., 2011. Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling Nature Protocols. 6(8), 1241-1249 STEPHENS, GILL and LICENCE, PETER, 2011. Ionic liquids Toxic or not? Chimica Oggi-Chemistry Today. 29(3), 72-75 TOOGOOD, HELEN S., FRYSZKOWSKA, ANNA, HULLEY, MARTYN, SAKUMA, MICHIYO, MANSELL, DAVID, STEPHENS, GILL M., GARDINER, JOHN M. and SCRUTTON, NIGEL S., 2011. A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity Chembiochem. 12(5), 738-749 WINDER, CATHERINE L., CORNMELL, ROBERT, SCHULER, STEPHANIE, JARVIS, ROGER M., STEPHENS, GILL M. and GOODACRE, ROYSTON, 2011. Metabolic fingerprinting as a tool to monitor whole-cell biotransformations Analytical and Bioanalytical Chemistry. 399(1), 387-401 WOOD, N., FERGUSON, J.L., NIMAL GUNARATNE, H.Q., SEDDON, K.R., GOODACRE, R. and STEPHENS, G.M., 2011. Screening ionic liquids for use in biotransformations with whole microbial cells Green Chemistry. 13(7), 1843-1851 K SEDDON, N GUNARATNE, M EARLE, M GILEA, G STEPHENS, E IVANOVA, L REHMANN, E GREEN, 2010. Compositions and methods for the removal of chewing gum residues from substrates. 2009-GB51097 2010023 11/01/2010 00:00:00 CA SELLICK, D KNIGHT, AS CROXFORD, AR MAQSOOD, GM STEPHENS, R GOODACRE, AJ DICKSON, 2010. Evaluation of extraction processes for intracellular metabolite profiling of mammalian cells: matching extraction approaches to cell type and metabolite targets. Metabolomics. 6, 427-438 CA SELLICK, R HANSEN, RASMUS, RM JARVIS, AR MAQSOOD, GM STEPHENS, AJ DICKSON, R GOODACRE, 2010. Rapid monitoring of recombinant antibody production by mammalian cell cultures using fourier transform infrared spectroscopy and chemometrics. Biotechnology and Bioengineering. 106, 432-442 N WOOD, G STEPHENS, 2010. Accelerating the discovery of biocompatible ionic liquids. Physical Chemistry Chemical Physics. 12, 1670-1674 A FRYSZKOWSKA, K FISHER, JM GARDINER, GM STEPHENS, 2010. A short, chemoenzymatic route to chiral beta-aryl-gamma-amino acids using reductases from anaerobic bacteria. Organic & Biomolecular Chemistry. 8, 533-535 HANSEN, R, DICKSON, AJ, GOODACRE, R, STEPHENS, GM and SELLICK, CA, 2010. Rapid Characterization of N-linked Glycans from Secreted and Gel-Purified Monoclonal Antibodies Using MALDI-ToF Mass Spectrometry Biotechnology and Bioengineering. 107(5), 902-908 HULLEY, ME, TOOGOOD, HS, FRYSZKOWSKA, A, MANSELL, D, STEPHENS, GM, GARDINER, JM and SCRUTTON, NS, 2010. Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries Chembiochem. 11(17), 2433-2447 M. REBROS, H.Q.N. GUNARATNE, J. FERGUSON, K.R. SEDDON, G. STEPHENS, 2009. A high throughput screen to test the biocompatibility of ionic liquids. Green Chemistry. 11, 402-408 O. DIPEOLU, E. GREEN, G. STEPHENS, 2009. Effects of water-miscible ionic liquids on cell growth and nitro reduction using Clostridium sporogenes. Green Chemistry. 11, Green Chemistry