Thomas, Neil R. - University of Nottingham

个人简介

Professor Thomas began his academic career with a 1st Class B.Sc. (Hons) in Chemistry from the University of Southampton in 1987. Remaining there, under the supervision of Professor D. Gani, he obtained his Ph.D. in 1990 working on the elucidation of the mechanism of the pyridoxal phosphate (vitamin B6) dependent enzyme serine hydroxymethyltransferase and 3-methylaspartase. He then worked for the following two years as a NATO/SERC Fellow with Prof. S. J. Benkovic at the Pennsylvania State University, USA. on both the generation and characterisation of catalytic antibodies and the reaction catalysed by dihydrofolate reductase. He returned to the UK in 1992 as a Royal Society University Research Fellow and lecturer at the University of Bath. In 1995, he moved to the School of Chemistry at the University of Nottingham, initially as a Royal Society University Research Fellow and lecturer and then in 2003 as a Senior Lecturer/Associate Professor before becoming Professor of Medicinal & Biological Chemistry in January 2008. His current research interests are in the identification of inhibitors of enzymes essential to Mycobacterium cell wall biosynthesis; synthesis of mechanistic probes based on Coenzyme A, S-adenosylmethione, ATP and biotin; use of enzymes in unusual reaction media (fluorous biphasic systems; supercritical fluids); development of enzyme-based antimicrobial therapies; development of enzyme-activated magnetic resonance imaging (MRI) agents; development of in vivo probes based on quantum dots and protein capsids. He is the Director and Admissions tutor for the Medicinal & Biological Chemistry degree courses.

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TURYANSKA, LYUDMILA, MORO, FABRIZIO, PATANE, AMALIA, BARR, JAMES, KOCKENBERGER, WALTER, TAYLOR, ALEXANDER, FAAS, HENRYK M., FOWLER, MAXINE, WIGMORE, PETER, TRUEMAN, REBECCA C., WILLIAMS, HUW E. L. and THOMAS, NEIL R., 2016. Developing Mn-doped lead sulfide quantum dots for MRI labels J. Mater. Chem. B. 4, 6797-6802 TAYLOR AJ, GRANWEHR J, LESBATS C, KRUPA JL, SIX JS, PAVLOVSKAYA GE, THOMAS NR, AUER DP, MEERSMANN T and FAAS HM, 2016. Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging. PloS one. 11(10), e0163704 HARVEY D, BARDELANG P, GOODACRE SL, COCKAYNE A and THOMAS NR, 2016. Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using "Click" Chemistry. Advanced materials (Deerfield Beach, Fla.). (In Press.) ZAMBERLAN, FRANCESCO, LESBATS, CLEMENTINE, ROGERS, NICOLA J., KRUPA, JAMES L., PAVLOVSKAYA, GALINA E., THOMAS, NEIL R., FAAS, HENRYK M. and MEERSMANN, THOMAS, 2015. Molecular Sensing with Hyperpolarized Xe-129 Using Switchable Chemical Exchange Relaxation Transfer CHEMPHYSCHEM. 16(11), 2294-2298 TURYANSKA, LYUDMILA, MAKAROVSKY, OLEG, SVATEK, SIMON A., BETON, PETER H., MELLOR, CHRISTOPHER J., PATANE, AMALIA, EAVES, LAURENCE, THOMAS, NEIL R., FAY, MICHAEL W., MARSDEN, ALEXANDER J. and WILSON, NEIL R., 2015. Ligand-Induced Control of Photoconductive Gain and Doping in a Hybrid Graphene-Quantum Dot Transistor ADVANCED ELECTRONIC MATERIALS. 1(7), HUMPHREYS, CHRISTOPHER M., MCLEAN, SAMANTHA, SCHATSCHNEIDER, SARAH, MILLAT, THOMAS, HENSTRA, ANNE M., ANNAN, FLORENCE J., BREITKOPF, RONJA, PANDER, BART, PIATEK, PAWEL, ROWE, PETER, WICHLACZ, ALEXANDER T., WOODS, CRAIG, NORMAN, RUPERT, BLOM, JOCHEN, GOESMAN, ALEXANDER, HODGMAN, CHARLIE, BARRETT, DAVID, THOMAS, NEIL R., WINZER, KLAUS and MINTON, NIGEL P., 2015. Whole genome sequence and manual annotation of Clostridium autoethanogenum, an industrially relevant bacterium BMC GENOMICS. 16, KURUPPU, ANCHALA I., ZHANG, LEI, COLLINS, HILARY, TURYANSKA, LYUDMILA, THOMAS, NEIL R. and BRADSHAW, TRACEY D., 2015. An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib ADVANCED HEALTHCARE MATERIALS. 4(18), 2816-2821 SABALA, IZABELA, JAGIELSKA, ELZBIETA, BARDELANG, PHILIP T., CZAPINSKA, HONORATA, DAHMS, SVEN O., SHARPE, JASON A., JAMES, RICHARD, THAN, MANUEL E., THOMAS, NEIL R. and BOCHTLER, MATTHIAS, 2014. Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans FEBS JOURNAL. 281(18), 4112-4122 CREN, SYLVAINE, GURCHA, SUDAGAR S, BLAKE, ALEXANDER J, BESRA, GURDYAL S and THOMAS, NEIL R, 2014. COD ID: 7151625 Crystallography Open Database. SADEGHI-KHOMAMI, ALI, FORCADA, TATIANA J, WILSON, CLAIRE, SANDERS, DAVID AR and THOMAS, NEIL R, 2014. COD ID: 7153247 Crystallography Open Database. ELEANOR R TURPIN, HUEY-JEN FANG, NEIL R. THOMAS and JONATHAN D. HIRST, 2013. Cooperativity and Site Selectivity in the Ileal Lipid Binding Protein Biochemistry. 52(27), 4723–4733 HARLAND, MICHAEL D., MAY, TERRY J. and THOMAS, NEIL R., 2013. Synthesis of a novel inhibitor of cell wall biosynthesis in Mycobacterium tuberculosis ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 245, TURPIN ER, FANG H, THOMAS NR and HIRST JD, 2013. Cooperativity and site selectivity in the ileal lipid binding protein. Biochemistry. 52(27), 4723-33 BRADSHAW, TRACEY D., JUNOR, MARC, PATANE, AMALIA, CLARKE, PHIL, THOMAS, NEIL R., LI, MEI, MANN, STEPHEN and TURYANSKA, LYUDMILA, 2013. Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells JOURNAL OF MATERIALS CHEMISTRY B. 1(45), 6254-6260 SADEGHI-KHOMAMI, ALI, THOMAS, NEIL R and WILSON, CLAIRE, 2013. COD ID: 2210218 Crystallography Open Database. PARTHA SK, SADEGHI-KHOMAMI, A, CREN, S, ROBINSON RI, WOODWARD, S, SLOWSKI, K, BERAST, L, ZHENG, B, THOMAS, NR and SANDERS, DAR, 2012. Identification of Novel Inhibitors of UDP-Galactopyranose Mutase by Structure-Based Virtual Screening Molecular Informatics. 30(10), 873-883 TURYANSKA, L, BRADSHAW, TD, LI, M, BARDELANG, P, DREWE, WC, FAY, MW, MANN, S, PATANE, A and THOMAS, NR, 2012. The Differential Effect Of Apoferritin-Pbs Nanocomposites On Cell Cycle Progression In Normal And Cancerous Cells Journal Of Materials Chemistry. 22(2), 660-665 TURYANSKA, LYUDMILA, BRADSHAW, TRACEY D., LI, MEI, BARDELANG, PHILIP, DREWE, WILLIAM C., FAY, MICHAEL W., MANN, STEPHEN, PATANE, AMALIA and THOMAS, NEIL R., 2011. The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells Journal of Materials Chemistry. 22, 660-665 SADEGHI-KHOMAMI, ALI, FORCADA, TATIANA J, WILSON, CLAIRE, SANDERS, DAVID A R and THOMAS, NEIL R, 2010. The UDP-Galp mutase catalyzed isomerization: synthesis and evaluation of 1,4-anhydro-beta-D-galactopyranose and its [2.2.2] methylene homologue. Organic & biomolecular chemistry. 8(7), 1596-602 ROTH, S. and THOMAS, N.R., 2010. A Concise Route to L-Azidoamino Acids: L-Azidoalanine, L-Azidohomoalanine and L-Azidonorvaline Synlett. 607-609 BENAISSI, K., POLIAKOFF, M. and THOMAS, N.R., 2010. Solubilisation of alpha-chymotrypsin by hydrophobic ion pairing in fluorous Green Chemistry. 12(1), 54-59 THOMAS, N. R., 2010. Cellular and Biomolecular Recognition: Synthetic and non-Biological Molecules. Edited by Raz Jelinek.. VOL 11(NUMBER 3), 435-435 ROTH, S, DREWE, WC and THOMAS, NR, 2010. A Concise And Scalable Route To L-Azidohomoalanine Nature Protocols. 5(12), 1967-1973 PARTHA, S.K., SADEGHI-KHOMAMI, A., SLOWSKI, K., KOTAKE, T., THOMAS, N.R., JAKEMAN, D.L. and SANDERS, D.A.R., 2010. Chemoenzymatic synthesis, inhibition studies, and X-ray crystallographic analysis of the phosphono analog of UDP-galp as an inhibitor and mechanistic probe for UDP-galactopyranose mutase Journal of Molecular Biology. 403(4), 578-590 KHIM, L, HAN, JA, WILLETTS, L, BRADY, K, GILLECE, P, RACHED, O, THOMAS, NR and STYLIANOU, E, 2010. Complementary Pcaf-Coenzyme A Mutagenesis: Chemoenzymatic Synthesis Of A Novel Enlarged Coenzyme A Analogue And Evaluation Of Its Biological Activity Chembiochem. 11(15), 2100-2103