Soultanas, Panos - University of Nottingham

个人简介

Panos Soultanas was born in Thessaloniki capital of the Greek province of Macedonia and came to the UK in 1982 to pursue A-level and University studies. He graduated from the University of Sheffield with a BSc honours degree (Biochemistry & Microbiology) in 1987 and completed his PhD studies in Biochemistry & Molecular Biology at the same University in 1990. His first post-doctoral position was on site-specific recombination at the University of Bristol (1990-1994), under the supervision of Prof. Steve Halford (FRS). After spending 12 months in the Greek Army (obligatory military service) he then moved to the University of Crete and spent a year and a half working on gene silencers of the gamma-globin locus. In September 1996 he moved to the University of Oxford where he worked in the group of Dr. Dale B. Wigley (FRS) on the structure and function relationships of DNA helicases. In September 2000 he was appointed as a lecturer in Chemical Biology at the School of Chemistry, University of Nottingham. In August 2004 he was promoted to Associate Professor and Reader in Biological Chemistry and from January 2008 to a Chair in Biological Chemistry.

研究领域

Prof. Soultanas' research interests are centered on the dynamics of large multiprotein assemblies like the primosome and replisome, focusing on protein-protein interactions mediated by DNA helicases. His current research interests include a number of replisomal and primosomal proteins such as PcrA and DnaB helicases, DnaG primase, DnaI replisomal protein, DnaX connector protein in the Gram +ve Bacillus. The lab also has an interest in the Bacillus subtilis DnaD-DnaB-DnaI primosomal cascade. The main focus of the lab is on recapitulating the entire DNA replication system of B. subtilis in vitro.

近期论文

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GREEN, M., HATTER, L., BROOKES, E., SOULTANAS, P. and SCOTT, D.J., 2016. Defining the Intrinsically Disordered C-terminal Domain of SSB Reveals DNA-mediated Compaction Journal of Molecular Biology. 428, 357-364 ALA'ALDEEN, DLAWER, MAHDAVI, JAFAR and SOULTANAS, PANOS, 2016. ANTIMICROBIAL COMPOUNDS AND COMPOSITIONS, AND USES THEREOF PCT/US2015/044603 01/01/1900 00:00:00 ASIANI, K.R., WILLIAMS, H., BIRD, L., JENNER, M., SEARLE, M.S., HOBMAN, J.L., SCOTT, D.J. and SOULTANAS, P., 2016. SilE is an intrinsically disordered periplasmic ‘molecular sponge’ involved in bacterial silver resistance Molecular Microbiology. 101(5), 731-742 NORTHALL, S.J., IVAN?I?-BA?E, I., SOULTANAS, P. and BOLT, E.L., 2016. Remodeling and control of homologous recombination by DNA helicases and translocases that target recombinases and synapsis Genes. 7(8), 52 VAN EIJK, E., PASCHALIS, V., GREEN, M., FRIGGEN, A.H., LARSON, M.A., SPRIGGS, K., BRIGGS, G.S., SOULTANAS, P. and SMITS, W.K., 2016. Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile: C. difficile helicase and primase Open Biology. 6(12), pii: 160272 GREEN, M., GILHOOLY, N.S., ABEDEEN, S., SCOTT, D.J., DILLINGHAM, M.S. and SOULTANAS, P., 2014. Engineering a Reagentless Biosensor for Single-Stranded DNA to Measure Real-Time Helicase Activity in Bacillus. Biosensors & Bioelectronics. 61, 579-586 AFONSO, J. P., CHINTAKAYALA, K., SUWANNACHART, C., SEDELNIKOVA, S., GILES, K., HOYES, J.B., SOULTANAS, P., RAFFERTY, J. and OLDHAM, N.J., 2013. Insights into the Structure and Assembly of the Bacillus subtilis Clamp-Loader Complex and its interaction with the replicative helicase. Nucleic Acids Research. 41(9), 5115-5126 RANNOU, O., LECHATELIER, E., LARSON, M., NOURI, H., DALMAIS, B., LAUGHTON, C., JANNIERE, L. and SOULTANAS, P., 2013. Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis Nucleic Acids Research. 41(10), 5303-5320 MAHDAVI, J., ROYER, P.-J., SJ?LINDER, H.S., AZIMI, S., SELF, T., STOOF, J., WHELDON, L.M., BR?NNSTR?M, K., WILSON, R., MORETON, J., MOIR, J.W.B., SIHLBOM, C., BORéN, T., JONSSON, A.-B., SOULTANAS, P. and ALA'ALDEEN, D.A.A., 2013. Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence Open Biology. 3, 130048 COLLIER, C, MACHON, C, BRIGGS, G.S, SMITS, W.K and SOULTANAS, P., 2012. Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites Nulceic Acids Research. 40(2), 739-750 SOULTANAS, P., 2012. Loading mechanisms of ring helicases at replication origins Molecular Microbiology. 84(1), 6-16 BRIGGS, G.S., SMITS, W.K. and SOULTANAS, P., 2012. The chromosomal replication machinery of low G+C content firmicutes Journal of Bacteriology. 194(19), 5162-5170 BOLT E and SOULTANAS P, 2012. Elongation: Primases & Helicases. In: BELL E, BOND J.S., SILER MASTERS B. S. and WELLS R.D., eds., Molecular Life Sciences: An Encyclopedic Reference Volume 1. Springer. SOULTANAS, P., 2011. The replication - transcription conflict Transcription. 2(3), 140-144 MERRIKH, H., MACH?N, C., GRAINGER, W.H., GROSSMAN, A.D. and SOULTANAS, P., 2011. Co-directional replication-transcription conflicts lead to replication restart Nature. 470(7335), 554-557 MARSTON, F.Y., GRAINGER, W.H., SMITS, W.K., HOPCROFT, N.H., GREEN, M., HOUNSLOW, A.M., GROSSMAN, A.D., CRAVEN, C.J. and SOULTANAS, P., 2010. When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD Nucleic Acids Research. 38(20), 6930-6942 MACHóN, C., LYNCH, G.P., THOMSON, N.H., SCOTT, D.J., THOMAS, C.D. and SOULTANAS, P., 2010. RepD-mediated recruitment of PcrA helicase at the Staphylococcus aureus pC221 plasmid replication origin, oriD Nucleic Acids Research. 38(6), 1874-1888 GRAINGER, W.H., MACHON, C., SCOTT, D.J. and SOULTANAS, P., 2010. DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilis. Nucleic Acids Research. 38(9), 2851-2864 LARSON, M.A, GRIEP, M.A, BRESSANI, R, CHINTAKAYALA, K and SOULTANAS, P. AND HINRICHS, S.H., 2010. Class-specific restrictions determine primase interactions with DNA template and replicative helicase. Nucleic Acids Research. 38(20), 7167-7178 CHINTAKAYALA, K, MACHON, C, HARONITI, A, LARSON, M.M, HINRICHS, S.H and GRIEP, M.A. AND SOULTANAS, P., 2009. Allosteric regulation of the primase (DnaG) actvity by the clamp-loader (tau) in vitro Molecular Microbiology.. 72(2), 537-549 ZHANG, W., MACHóN, C., ORTA, A., PHILLIPS, N., ROBERTS, C.J., ALLEN, S. and SOULTANAS, P., 2008. Single molecule atomic force spectroscopy reveals that DnaD forms scaffolds and enhances duplex melting Journal of Molecular Biology. 377(3), 706-714 SAMARASINGHE, S., EL-ROBH, M., GRAINGER, D., ZHANG, W., SOULTANAS, P. and BUSBY, S., 2008. Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR. Nucleic Acids Research.. 36(8), 2667-2676 SCHNEIDER, S., ZHANG, W., SOULTANAS, P. and PAOLI, M., 2008. Structure of the N-terminal oligomerization domain of DnaD reveals a unique tetramerizaion motif and provides insights into scaffold formation Journal of Molecular Biology. 376(5), 1237-1250 CHINTAKAYALA, K, LARSON, M.A, GRIEP, M.A and HINRICHS, S.H. AND SOULTANAS, P., 2008. Conserved residues of the C-terminal p16 domain of primase are involved in modulating the activity of the bacterial primosome. Molecular Microbiology.. 68(2), 360-371 ZHANG, W., DILLINGHAM, M.S., THOMAS, C.D., ALLEN, S., ROBERTS, C.J. and SOULTANAS, P., 2007. Directional loading of the PcrA helicase at the plasmid replication origin oriD by RepD, and unwinding of a plasmid. Journal of Molecular Biology. 371(2), 336-348