Paradisi, Francesca - University of Nottingham

个人简介

Dr. Paradisi completed an MSc in Organic Chemistry from the University of Bologna in 1998 under the supervision of Prof. Cainelli. In 2002 she completed her PhD at the same institution with a thesis on the synthesis of non-natural amino acids via diketopiperazine scaffolds. She joined the group of Prof. Engel at University College Dublin as Post-Doctoral Fellow where she remained until 2005 and developed several projects mainly focused on amino acid dehydrogenases and their applications in the synthesis of non-natural amino acids. She joined Enzolve Technologies in 2005, a spin-off company of UCD where she worked on the use of mutant dehydrogeanse enzymes for neonatal screening of metabolic disorders. in 2006 she was appointed College Lecturer in Chemical Biology at the UCD School of Chemistry. She was promoted in 2014 to Senior Lecturer and in 2016 she took up the position of Associate Professor in Biocatalysis and Enzyme Engineering in the School of Chemistry at the Univeristy of Nottingham

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MATTEO PLANCHESTAINER, MARTINA LETIZIA CONTENTE, JENNIFER CASSIDY, FRANCESCO MOLINARI, LUCIA TAMBORINI and FRANCESCA PARADISI, 2017. Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata Green Chemistry. 19, 372-375 WESTER, ANITA, O'REILLY, ELAINE, DEVOCELLE, MARC, GALLAGHER, PATRICIA E. and PARADISI, FRANCESCA, 2016. Biological Screening of Angiotensin-(1-7) Analogues incorporating the Non-natural delta-Amino Acid ACCA AMINO ACIDS. 48(2), 636-636 KUTASY, BALAZS, FRIEDMACHER, FLORIAN, PES, LARA, COYLE, DAVID, DOI, TAKASHI, PARADISI, FRANCESCA and PURI, PREM, 2016. Antenatal retinoic acid administration increases trophoblastic retinol-binding protein dependent retinol transport in the nitrofen model of congenital diaphragmatic hernia. Pediatric research. 79(4), 614-20 CONTENTE, MARTINA LETIZIA, PLANCHESTAINER, MATTEO, MOLINARI, FRANCESCO and PARADISI, FRANCESCA, 2016. Stereoelectronic effects in the reaction of aromatic substrates catalysed by Halomonas elongata transaminase and its mutants ORGANIC & BIOMOLECULAR CHEMISTRY. 14(39), 9306-9311 TAKAHASHI, HIROMIZU, KUTASY, BALAZS, PES, LARA, PARADISI, FRANCESCA and PURI, PREM, 2015. Decidual beta-carotene-15,15 '-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia PEDIATRIC SURGERY INTERNATIONAL. 31(1), 37-43 CERIOLI, LORENZO, PLANCHESTAINER, MATTEO, CASSIDY, JENNIFER, TESSARO, DAVIDE and PARADISI, FRANCESCA, 2015. Characterization of a novel amine transaminase from Halomonas elongata JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. 120, 141-150 ALSAFADI, DIYA and PARADISI, FRANCESCA, 2014. Covalent Immobilization of Alcohol Dehydrogenase (ADH2) from Haloferax volcanii: How to Maximize Activity and Optimize Performance of Halophilic Enzymes MOLECULAR BIOTECHNOLOGY. 56(3), 240-247 STRECIWILK, WOJCIECH, CASSIDY, JENNIFER, HACKENBERG, FRAUKE, MUELLER-BUNZ, HELGE, PARADISI, FRANCESCA and TACKE, MATTHIAS, 2014. Synthesis, cytotoxic and antibacterial studies of p-benzyl-substituted NHC-silver(I) acetate compounds derived from 4,5-di-p-diisopropylphenyl- or 4,5-di-p-chlorophenyl-1H-imidazole JOURNAL OF ORGANOMETALLIC CHEMISTRY. 749, 88-99 KUTASY, BALAZS, FRIEDMACHER, FLORIAN, PES, LARA, PARADISI, FRANCESCA and PURI, PREM, 2014. Increased uptake of dietary retinoids at the maternal-fetal barrier in the nitrofen model of congenital diaphragmatic hernia JOURNAL OF PEDIATRIC SURGERY. 49(6), 866-870 KUTASY, BALAZS, PES, LARA, FRIEDMACHER, FLORIAN, PARADISI, FRANCESCA and PURI, PREM, 2014. Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia PEDIATRIC SURGERY INTERNATIONAL. 30(10), 1017-1022 PANDURANGAN, KOMALA, KITCHEN, JONATHAN A., BLASCO, SALVADOR, PARADISI, FRANCESCA and GUNNLAUGSSON, THORFINNUR, 2014. Supramolecular pyridyl urea gels as soft matter with antibacterial properties against MRSA and/or E-coli CHEMICAL COMMUNICATIONS. 50(74), 10819-10822 TIMPSON, L.M., LILIENSIEK, A.-K., ALSAFADI, D., CASSIDY, J., SHARKEY, M.A., LIDDELL, S., ALLERS, T. and PARADISI, F., 2013. A comparison of two novel alcohol dehydrogenase enzymes (adh1 and adh2) from the extreme halophile haloferax volcanii Applied Microbiology and Biotechnology. 97(1), 195-203 O'REILLY, ELAINE, PES, LARA, ORTIN, YANNICK, MUELLER-BUNZ, HELGE and PARADISI, FRANCESCA, 2013. Synthesis of a conformationally constrained delta-amino acid building block AMINO ACIDS. 44(2), 511-518 HACKENBERG, FRAUKE, LALLY, GRAINNE, MUELLER-BUNZ, HELGE, PARADISI, FRANCESCA, QUAGLIA, DANIELA, STRECIWILK, WOJCIECH and TACKE, MATTHIAS, 2013. Synthesis and biological evaluation of N-heterocyclic carbene-silver(I) acetate complexes derived from 4,5-ditolyl-imidazole INORGANICA CHIMICA ACTA. 395, 135-144 ROBERTSON, KEITH, MURPHY, CORMAC D. and PARADISI, FRANCESCA, 2013. The synthesis and biological testing of bacilysin analogues AMINO ACIDS. 45(5), 1157-1168 QUAGLIA, DANIELA, PORI, MATTEO, GALLETTI, PAOLA, EMER, ENRICO, PARADISI, FRANCESCA and GIACOMINI, DANIA, 2013. His-tagged Horse Liver Alcohol Dehydrogenase: Immobilization and application in the bio-based enantioselective synthesis of (S)-arylpropanols PROCESS BIOCHEMISTRY. 48(5-6), 810-818 TIMPSON, LEANNE M., LILIENSIEK, ANN-KATHRIN, ALSAFADI, DIYA, CASSIDY, JENNIFER, SHARKEY, MICHAEL A., LIDDELL, SUSAN, ALLERS, THORSTEN and PARADISI, FRANCESCA, 2013. A comparison of two novel alcohol dehydrogenase enzymes (ADH1 and ADH2) from the extreme halophile Haloferax volcanii APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 97(1), 195-203 ALSAFADI, DIYA and PARADISI, FRANCESCA, 2013. Effect of organic solvents on the activity and stability of halophilic alcohol dehydrogenase (ADH2) from Haloferax volcanii EXTREMOPHILES. 17(1), 115-122 LILIENSIEK, ANN-KATHRIN, CASSIDY, JENNIFER, GUCCIARDO, GABRIELE, WHITELY, CLIADHNA and PARADISI, FRANCESCA, 2013. Heterologous Overexpression, Purification and Characterisation of an Alcohol Dehydrogenase (ADH2) from Halobacterium sp NRC-1 MOLECULAR BIOTECHNOLOGY. 55(2), 143-149 BALDUCCI, DANIELE, CONWAY, PHILIP A., SAPUPPO, GIULIA, MUELLER-BUNZ, HELGE and PARADISI, FRANCESCA, 2012. Novel approach to the synthesis of aliphatic and aromatic alpha-keto acids TETRAHEDRON. 68(36), 7374-7379 TIMPSON, LEANNE M., ALSAFADI, DIYA, MAC DONNCHADHA, CILLIN, LIDDELL, SUSAN, SHARKEY, MICHAEL A. and PARADISI, FRANCESCA, 2012. Characterization of alcohol dehydrogenase (ADH12) from Haloarcula marismortui, an extreme halophile from the Dead Sea EXTREMOPHILES. 16(1), 57-66 LESTINI, ELENA, ROBERTSON, KEITH, MURPHY, CORMAC D. and PARADISI, FRANCESCA, 2012. ALTERNATIVE MILD ROUTE TO THE SYNTHESIS OF 4-METHYLENECYCLOHEX-2-ENONE, A KEY MOIETY OF THE ANTICANCER COMPOUNDS OTTELIONE A AND B SYNTHETIC COMMUNICATIONS. 42(12), 1864-1876 QUAGLIA, DANIELA, IRWIN, JANE A. and PARADISI, FRANCESCA, 2012. Horse Liver Alcohol Dehydrogenase: New Perspectives for an Old Enzyme MOLECULAR BIOTECHNOLOGY. 52(3), 244-250 HACKENBERG, FRAUKE, LALLY, GRAINNE, MUELLER-BUNZ, HELGE, PARADISI, FRANCESCA, QUAGLIA, DANIELA, STRECIWILK, WOJCIECH and TACKE, MATTHIAS, 2012. Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes - Synthesis and biological evaluation JOURNAL OF ORGANOMETALLIC CHEMISTRY. 717, 123-134 PANDURANGAN, KOMALA, MURNAGHAN, KEVIN D., WALSHE, AURORA, MUELLER-BUNZ, HELGE, PARADISI, FRANCESCA and MORGAN, GRACE G., 2011. Design, Synthesis and Structure of Novel Para-Quinones and their Antibacterial Activity CHEMICAL BIOLOGY & DRUG DESIGN. 78(5), 787-799