个人简介

Outstanding Mentor Award, Consortium for Women & Research (2013) ACS WCC Rising Star Award (2012) Thieme Chemistry Journal Award (2011) NSF CAREER Award (2009) 3M Nontenured Faculty Award (2009) Appointed to UC Davis faculty (2007) Abbott Laboratories Graduate Research Fellow (2000) NIH Postdoctoral Fellow, Harvard University (2002-05) Ph.D. University of California, Irvine B.S. Trinity University, San Antonio, TX

研究领域

Chemical Biology/Organic Chemistry

Research in the Franz group combines organic synthesis, catalyst development, and chemical biology with applications for the synthesis of bioactive products, biofuels and materials. Our primary focus is to develop new reactions and catalysts for the efficient and enantioselective synthesis of bioactive and therapeutically-relevant molecules. An integral part of our research is to investigate the mechanism and molecular interactions that dictate the reactivity and selectivity of these synthetic transformations. In addition to developing new transformations for the synthesis of complex small molecules, we are interested in using chemical triggers to enhance the production of lipids in microalgae for biofuels.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines. J. J. Badillo, C. J. A. Ribeiro, M. M. Olmstead, A. K. Franz*. Org. Lett 2014, 16, 6270. Synthesis of spiropyrroline oxindoles. Distinct Roles for Mitogen-Activated Protein Kinase Signaling and Calmodulin-Binding Transcriptional Activator3 in Regulating the Peak Time and Amplitude of the Plant General Stress Response. M. Bjornson, G Benn, X. Song, L. Comai, A. K. Franz, A. M. Dandekar, G. Drakakaki, K. Dehesh*. Plant Physiology 2014, 166, 988. Plant Stress responses Catalytic Enantioselective Carboannulation with Allylsilanes. N. R. Ball-Jones, J. J. Badillo, N. T. Tran, and A. K. Franz*. Angew. Chem. Int. Ed. 2014, 53, 9462. The first [3+2] allylsilane carboannulation Counterion effects in the catalytic stereoselective synthesis of 2,3'-pyrrolidinyl spirooxindoles. J. P. MacDonald, B. H. Shupe, J. D. Schreiber, and A. K. Franz*. Chem. Commun. 2014, 50, 5242. crotylation of iminooxindoles Supramolecular hydrogen-bonding assembly of silanediols with bifunctional heterocycles. N. T. Tran, S. O. Wilson, and A. K. Franz*. Chem. Commun. 2014, 50, 3738. supramolecular assembly of silanediols A comparison of lipid storage in Phaeodactylum tricornutum and Tetraselmis Suecica, using laser scanning confocal microscopy. D. M. Wong, and A. K. Franz*. J. Microbiol. Methods 2013, 95, 122. Confocal Microscopy with algae Synthesis of Spirocarbamate Oxindoles via Intramolecular Trapping of a B-silyl Carbocation by an N-Boc Group. B. H. Shupe, E. E. Allen, J. P. MacDonald, S. O. Wilson, and A. K. Franz*. Org. Lett. 2013, 15, 3218. Trapping B silyl carbocations Phenotypic Screening with Oleaginous Microalgae Reveals Modulators of Lipid Productivity. A. K. Franz*, M. A. Danielwicz, and D. M. Wong, L. A. Anderson, and J. R. Boothe. ACS Chem. Biol. 2013, 8, 1053. Small molecule modulators of lipid production Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds. A. K. Franz*, N. V. Hanhan, and N. R. Ball-Jones. ACS Catal. 2013, 3, 540. Review of the asymmetric synthesis of spirocyclic compounds Organosilicon Molecules with Medicinal Applications. S. O. Wilson, and A. K. Franz*. J. Med. Chem. 2013, 56, 388. Organosilicon molecules in medicinal chemistry An improved high-throughput Nile red fluorescence assay for estimating intracellular lipids in a variety of yeast species. I. R. Sitepu, L. Ignatia, A. K. Franz, D. M. Wong, S. A. Faulina, M. Tsui, A. Kanti, K. Boundy-Mills. J. Microbiol. Methods, 2012, 91, 321. NMR and X-ray Studies of Hydrogen Bonding for Amide-Containing Silanediols. S. O. Wilson, N. T. Tran, and A. K. Franz*. Organometallics 2012, 31, 6715. Silanediol studies Real-Time Monitoring of Transesterification by 1H NMR Spectroscopy: Catalyst Comparison and Improved Calculation for Biodiesel Conversion. L. A. Anderson, and A. K. Franz*. Energy Fuels 2012, 26, 6404. Real time monitoring of transesterification Enantiocontrol with a Hydrogen-bond Directing Pyrrolidinylsilanol Catalyst. T. Min, J. C. Fettinger, and A. K. Franz*. ACS Catal. 2012, 2, 1661. Enantioselective allylation using allylsilane nucleophiles Scandium(III)-Catalyzed Enantioselective Allylation of Isatins Using Allylsilanes. N. V. Hanhan, Y. C. Tang, N. T. Tran, and A. K. Franz*. Org. Lett. 2012, 14, 2218. Enantioselective allylation using allylsilane nucleophiles Strategies for the enantioselective synthesis of spirooxindoles. N. R. Ball-Jones, J. J. Badillo and A. K. Franz*. Org. and Biomol. Chem. 2012, 10, 5165. Review of strategies for the synthesis of spirooxindoles Catalytic Stereoselective Synthesis of Diverse Oxindoles and Spirooxindoles from Isatins. J. P. MacDonald, J. J. Badillo, G. E. Arevalo, A. Silva-Garcia and A. K. Franz*. ACS Comb. Sci. 2012, 14, 285. Synthesis of a diverse library of oxindoles Catalytic Asymmetric [3+2] Annulation of Allylsilanes with Isatins: Synthesis of Spirooxindoles. N. V. Hanhan, N. R. Ball-Jones, N. T. Tran and A. K. Franz*. Angew. Chem. Int. Ed. 2012, 51, 989. First Catalytic Asymmetric [3+2] allylsilane annulation reaction Cooperative Hydrogen-Bonding Effects in Silanediol Catalysis. N. T. Tran, S. O. Wilson, and A. K. Franz*. Org. Lett. 2012, 14, 186. Silanediol Catalysis Enantioselective and Regioselective Indium(III)-Catalyzed Addition of Pyrroles to Isatins. E. G. Gutierrez, C. J. Wong, A. H. Sahin, and A. K. Franz*. Org. Lett. 2011, 13, 5754.