Mitchell, Nicholas - University of Nottingham

个人简介

Nicholas Mitchell received an MChem degree from the University of Southampton in 2004, before joining Prof. Stefan Howorka's group at UCL to investigate the chemical modification of oligonucleotides in 2005. He was awarded a Graduate Research Scholarship in 2008 and received his PhD in 2009. Nick remained at UCL as a PDRA under the joint supervision of Prof. Alethea Tabor and Prof. Helen Hailes to work on MRI and SPECT imaging of liposomal drug delivery. In 2013 he moved to Prof. Richard Payne's lab at the University of Sydney to develop novel peptide ligation methodologies. Nick took up a Nottingham Research Fellowship in October 2016 to focus on the chemical synthesis of therapeutic proteins.

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ROGERS, S., FEY, D., MCCLOY, R. A., PARKER, B. L., MITCHELL, N. J., PAYNE, R. J., DALY, R. J., JAMES, D. E., CALDON, C. E., WATKINS, D. N., CROUCHER, D. R. and BURGESS, A., 2016. PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells JOURNAL OF CELL SCIENCE. 129(7), 1340-1354 ISAHAK, N., GODY, G., MALINS, L. R., MITCHELL, N. J., PAYNE, R. J. and PERRIER, S., 2016. Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation CHEMICAL COMMUNICATIONS. 52, 12952-12955 MITCHELL, N. J., KULKARNI, S. S., MALINS, L. R., WANG, S. and PAYNE, R. J., 2016. One-pot ligation-oxidative deselenization at selenocystine and selenocysteine CHEMISTRY A EUROPEAN JOURNAL. (In Press.) MALINS, L. R., MITCHELL, N. J., MCGOWAN, S. and PAYNE, R. J., 2015. Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(43), 12716-12721 MITCHELL, N. J., MALINS, L. R., LIU, X., THOMPSON, R. E., CHAN, B., RADOM, L. and PAYNE, R. J., 2015. Rapid Additive-Free Selenocystine-Selenoester Peptide Ligation JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 137(44), 14011-14014 MALINS, L. R., MITCHELL, N. J. and PAYNE, R. J., 2014. Peptide ligation chemistry at selenol amino acids JOURNAL OF PEPTIDE SCIENCE. 20(2), 64-77 MITCHELL, N., KALBER, T. L., COOPER, M. S., SUNASSEE, K., CHALKER, S. L., SHAW, K. P., ORDIDGE, K. L., BADAR, A., JANES, S. M., BLOWER, P. J., LYTHGOE, M. F., HAILES, H. C. and TABOR, A. B., 2013. Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging BIOMATERIALS. 34(4), 1179-1192 BUCHSBAUM, S. F., MITCHELL, N., MARTIN, H., WIGGIN, M., MARZIALI, A., COVENEY, P. V., SIWY, Z. and HOWORKA, S., 2013. Disentangling Steric and Electrostatic Factors in Nanoscale Transport Through Confined Space NANO LETTERS. 13, 3890-3896 LEITNER, M., MITCHELL, N., KASTNER, M., SCHLAPAK, R., GRUBER, H. J., HINTERDORFER, P., HOWORKA, S. and EBNER, E., 2011. Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra ACS NANO. 5, 7048-7054 MITCHELL, N., EBNER, A., HINTERDORFER, P., TAMPE, R. and HOWORKA, S., 2010. Chemical Tags Mediate the Orthogonal Self-Assembly of DNA Duplexes into Supramolecular Structures SMALL. 6(16), 1732-1735 MITCHELL, N., SCHLAPAK, R., KASTNER, M., ARMITAGE, D., CHRZANOWSKI, W., RIENER, J., HINTERDORFER, P., EBNER, A. and HOWORKA, S., 2009. A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 48(3), 525-527 BORSENBERGER, V., MITCHELL, N. and HOWORKA, S., 2009. Chemically Labeled Nucleotides and Oligonucleotides Encode DNA for Sensing with Nanopores JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131(22), 7530-7531 MITCHELL, N. and HOWORKA, S., 2008. Chemical tags facilitate the sensing of individual DNA strands with nanopores ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 47(30), 5565-5568 MARTIN, H., KINNS, H., MITCHELL, N., ASTIER, Y., MADATHIL, R. and HOWORKA, S., 2007. Nanoscale protein pores modified with PAMAM dendrimers JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 129(31), 9640-9649