Dowden, James - University of Nottingham

个人简介

Dr. Dowden gained a B.Sc in Chemistry from the University of Sheffield in 1993, then moved to the University of Southampton and completed a PhD under the supervision of Prof. J. D. Kilburn in 1996. He then worked as a postdoc with Professors N. J. Turner and S. L. Flitsch at the Edinburgh Centre for Protein Technology within the Chemistry Department, University of Edinburgh for two and a half years. In 1999 he was appointed as Lecturer in Medicinal Chemistry at the University of Bath. In 2005 he moved to his present position of Lecturer in Chemical Biology at the University of Nottingham.

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DAY, JONATHAN, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2016. Stereoselective Synthesis of Tetrahydroindolizines through the Catalytic Formation of Pyridinium Ylides from Diazo Compounds ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 55(19), 5809-5813 HANSON-HEINE, MAGNUS W. D., WRIGLESWORTH, ALISDAIR, UROOS, MALIHA, CALLADINE, JAMES A., MURPHY, THOMAS S., HAMILTON, MICHELLE, CLARK, IAN P., TOWRIE, MICHAEL, DOWDEN, JAMES, BESLEY, NICHOLAS A. and GEORGE, MICHAEL W., 2015. Calculating singlet excited states: Comparison with fast time-resolved infrared spectroscopy of coumarins JOURNAL OF CHEMICAL PHYSICS. 142(15), YOU, B., HAMER, K., LEWIS, W. and DOWDEN, J., 2013. An unusual silicon mediated transannular cyclopropanation Chemical Communications. 49(8), 795-797 DAY, JONATHAN, UROOS, MALIHA, CASTLEDINE, RICHARD A, LEWIS, WILLIAM, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2013. Alkaloid inspired spirocyclic oxindoles from 1,3-dipolar cycloaddition of pyridinium ylides. Organic & biomolecular chemistry. 11(38), 6502-9 DOWDEN, J., PIKE, R.A., PARRY, R.V., HONG, W., MUHSEN, U.A. and WARD, S.G., 2011. Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1 Organic and Biomolecular Chemistry. 9(22), 7814-7821 STEVENSON, B., LEWIS, W. and DOWDEN, J., 2010. Expedient Route to an Amine Precursor of Halichlorine and Pinnaic Acid from Nitrocyclopent-1-ene Synlett. NUMB 4, 672-674 DOWDEN, J., HONG, W., PARRY, R.V., PIKE, R.A. and WARD, S.G., 2010. Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases Bioorganic and Medicinal Chemistry Letters. 20(7), 2103–2105 DAMMERMANN, W., ZHANG, B., NEBEL, M., CORDIGLIERI, C., ODOARDI, F., KIRCHBERGER, T., KAWAKAMI, N., DOWDEN, J., SCHMID, F., DORNMAIR, K., HOHENEGGER, M., FLÜGEL, A., GUSE, A.H. and POTTER, B.V.L., 2009. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist Proceedings of the National Academy of Sciences of the United States of America. 106(26), 10678-10683 PARKESH, R., LEWIS, A.M., ALEY, P.K., ARREDOUANI, A., ROSSI, S., TAVARES, R., VASUDEVAN, S.R., ROSEN, D., GALIONE, A., DOWDEN, J. and CHURCHILL, G.C., 2008. Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells Cell Calcium. 43(6), 531–538 FOSTER, S.R., PEARCE, A., BLAKE, A.J., WELHAM, M.J. and DOWDEN, J., 2007. Novel octavalent cross-linker displays efficient trapping of protein–protein interactions Chemical Communications. 24, 2512-2514 ANDERSON, C., BARTLETT, S.J., GANSNER, J.M., WILSON, D., HE, L., GITLIN, J.D., KELSH, R.N. and DOWDEN, J., 2007. Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis Molecular BioSystems. 3(1), 51-59 PARKESH, RAMAN, VASUDEVAN, SRIDHAR R, BERRY, ALEXANDRA, GALIONE, ANTONY, DOWDEN, JAMES and CHURCHILL, GRANT C, 2007. Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP(+)). Organic and Biomolecular Chemistry. 5(3), 441-3 DOWDEN, J., BERRIDGE, G., MOREAU, C., YAMASAKI, M., CHURCHILL, G.C., POTTER, B.V.L. and GALIONE, A., 2006. Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release Chemistry & Biology. 13(6), 659-665 YIAKOUVAKI, A., SAVOVIĆ, J., AL-QENAEI, A., DOWDEN, J. and POURZAND, C., 2006. Caged-iron chelators a novel approach towards protecting skin cells against UVA-induced necrotic cell death Journal of Investigative Dermatology. 126(10), 2287-2295 POTTER,B.V.L., DOWDEN,J. and GALIONE,A., 2005. Therapeutics WO2005054198-A2 06/01/2005 00:00:00 DOWDEN,J., BROWN,R.S., MOREAU,C., GALIONE,A. and POTTER,B.V., 2005. Chemical synthesis of the novel Ca2+ messenger NAADP. Nucleosides, Nucleotides and Nucleic Acids. 24(5-7), 513-518 DOWDEN, J., MOREAU, C., BROWN, R.S., BERRIDGE, G., GALIONE, A. and POTTER, B.V.L., 2004. Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate Angewandte Chemie International Edition. 43(35), 4637-4640 GALIONE, A., PARRINGTON, J. and DOWDEN, J., 2004. The NAADP receptor: commentary on Billington et al British Journal of Pharmacology. VOL 142(PART 8), 1203-1208 WARD,S., SOTSIOS,Y., DOWDEN,J., BRUCE,I. and FINAN,P., 2003. Therapeutic potential of phosphoinositide 3-kinase inhibitors Chemistry & Biology. 10(3), 207-213 BROWN, R. S., DOWDEN, J., MOREAU, C. and POTTER, B. V., 2002. A concise route to tiazofurin Tetrahedron Letters. VOL 43(NUMBER 37), 6561 - 6562 YANG, J., DOWDEN, J., TATIBOUET, A., HATANAKA, Y. and HOLMAN, G. D., 2002. Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5 Biochemical Journal. VOL 367(PART 2), 533-539 DOWDEN, J. and SAVOVIĆ, J., 2001. Olefin metathesis in non-degassed solvent using a recyclable, polymer supported alkylideneruthenium Chemical Communications. 1, 37-38 DOWDEN,J. and WARD,S.G., 2001. Inhibitors of p56(lck): assessing their potential as tools for manipulating T-lymphocyte activation Expert Opinion on Therapeutic Patents. 11(2), 295-306