Denton, Ross - University of Nottingham

个人简介

Ross began his research career at The University of Nottingham where he carried out his PhD studies with Professor J.C. Anderson (2001-2004). At the beginning of 2005 he moved to the Scripps Research Institute, La Jolla, USA to carry out postdoctoral research with Professor K.C. Nicolaou. In mid 2007 he returned to the UK to take up a further postdoctoral position with Professor S.V. Ley CBE, FRS at The University of Cambridge. Ross returned to The University of Nottingham to begin his independent research career as a Lecturer in Organic Chemistry (fixed-term) in September 2008. In June 2009 he was appointed to a permanent lectureship and promotion to Associate Professor followed in 2016.

研究领域

Our research involves the design and development of new reactions, synthesis methods, and catalysts that allow us (and others) to make valuable organic molecules such as natural products and pharmaceuticals more efficiently. This activity is underpinned by a core interest in organophosphorus and organosilicon chemistry. At present we have projects running on amination reactions, amidation reactions, novel bioisosteres and building blocks for drug discovery, fluorination chemistry, alcohol activation and total synthesis.

近期论文

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Redox Neutral Organocatalytic Mitsunobu Reactions Beddoe, R.H.; Andrews, K.G.; Magne, V.; Cuthbertson, J.D.; Saska, J.; Shannon-Little, A.L.; Shanahan, S.E.; Sneddon, H.F.; Denton, R.M. Science, 2019, 365, 910 The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the art Beddoe, R.H.; Sneddon, H.F.; Denton, R.M. Org. Biomol. Chem. 2018, 16, 7774 A More Critical Role for Silicon in the Catalytic Staudinger Amidation: Silanes as Non-Innocent Reductants Andrews, K.; Denton, R.M. Chem. Commun. 2017, 53, 7971. Front cover. A Practical and Catalyst-Free Trifluoroethylation Reaction of Amines Using Trifluoroacetic Acid. Andrews, K.; Faizova, R.; Denton, R.M. Nature Commun. 2017, 8, 15913. Synthesis of Malhamensilipin A Exploiting Iterative Epoxidation/Chlorination: Experimental and Computational Analysis of Epoxide-Derived Chloronium Ions Saska, J.; Lewis, W.; Paton, R.; Denton R.M. Chem. Sci. 2016, 7, 7040. Synthesis of Quaternary Aryl Phosphonium Salts: Photoredox Initiated Phosphine Arylation Fearnley, A.F.; An, J.; Jackson, M.; Lindovska, P.; Denton, R.M. Chem. Commun. 2016, 52, 4987. Catalytic Reductive N-Alkylation of Amines using Carboxylic Acids Andrews, K.; Summers, D.; Donnelly, L.; Denton, R.M. Chem. Commun. 2016, 52, 1855.Table of contents graphic amination chem comm Development of a Redox-Free Mitsunobu Reaction Exploiting Phosphine Oxides as Precursors to Dioxyphosphoranes Tang, X.; Chapman, C.; Whiting M.; Denton, R.M. Chem. Commun. 2014, 50, 7340. mitsunobu chem comm The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions Jie, A.; Denton, R.M.; Lambert T.L.; Nacsa, E. Org. Biomol. Chem. 2014, 12, 2993. A Simple Method for Appel Reactions Using a Polystyrene Supported Phopshine Oxide Tang, X.; An, J.; Denton, R.M. Tetrahedron Lett. 2014, 4, 799. Heteroatom Methods (review article) An, J.; Denton, R.M. Annu. Rep. Org. Chem., Sect. B: Org. Chem. 2013, 109, 167. Phosphorus(V)-Catalysed Dichlorination Reactions of Aldehydes An, J.; Tang, X.; Moore, J.; Lewis, W.; Denton, R.M. Tetrahedron 2013, 69, 8769. A Strategy For The Synthesis Of The Fargenone/Fargenin Family of Natural Products: Synthesis Of The Tricyclic Core R.M. Denton, J.S. Scragg, Org. Biomol. Chem 2012, 10, 5629 graphical abstract fargenin core Phosphonium Salt-Catalysed Synthesis of Nitriles From In Situ Activated Oximes Denton R.M.; An, J.; Lindovska, P.; Lewis, W. Tetrahedron, 2012, 68, 2899 Catalytic Phosphorus(V)-Mediated Nucleophilic Substitution Reactions: Development Of A Catalytic Appel Reaction Denton, R.M.; An, J.; Adeniran, B.; Blake, A.; Lewis, W.; Poulton, A. J. Org. Chem. 2011, 76, 6749 A Concise Synthesis of O-methyl Honokiol Denton, R.M.; Scragg, J.T.; Saska, J. Tetrahedron Lett. 2011, 52, 2554 Catalysis of Phosphorus(V)-Mediated Transformations: Catalytic Dichlorination of Epoxides Under Appel Conditions Denton, R.M.; Tang, X.; Przeslak, A. Org. Lett. 2010, 12, 4678 Phosphine Oxide-Catalysed Chlorination of Alcohols Under Appel Conditions Denton, R.M.; An, J. ; Adeniran, B. Chem. Commun. 2010, 46, 3025 A Concise Synthesis Of Honokiol Denton, R.M.; Scragg, J.T.; Galofre, A.M.; Gui, X.; Lewis, W. Tetrahedron 2010, 66, 8029 A Concise Synthesis Of Dunnianol Denton, R.M.; Scragg, J.T. Synlett 2010, 633