Ball, Liam - University of Nottingham

个人简介

Liam read undergraduate chemistry at the University of Bristol, conducting final-year research with Dr Chris Russell in the field of main group synthesis. Upon completion of his MSci in 2009, Liam began Ph.D. studies under the co-supervision of Dr Chris Russell and Prof. Guy Lloyd-Jones FRS. During this time, his research concerned the development and mechanistic investigation of gold-catalysed coupling methodologies. In December 2013, Liam relocated to Edinburgh to conduct post-doctoral research with Prof. Guy Lloyd-Jones FRS on mechanistic aspects of palladium catalysis. Liam was appointed to the post of Assistant Professor of Organic Chemistry at the School of Chemistry, University of Nottingham, in July 2015.

研究领域

The exploitation of mechanistic insight to inform the development of efficient, catalytic approaches to carbon-carbon and carbon-heteroatom bond-formation is a central research theme in the Ball group. Although accurate prediction of molecular function from structure alone remains a challenge across all areas of synthetic chemistry, it is particularly difficult in the field of homogeneous catalysis: any given feature of a catalyst that benefits one step of a cycle, such as its ligand sphere or oxidation state, may have a lesser or an opposing effect in subsequent steps. Our approach is to use the tools of physical organic chemistry - including isotopic labelling, kinetic studies and analysis of structure-activity relationships - to gain an understanding of a reaction's mechanism and to quantify the requirements of the catalyst. This insight provides the basis for both informed catalyst optimisation and, ultimately, de novo reaction design.

近期论文

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Skeletal Editing: Interconversion of Arenes and Heteroarenes (2023)Journal Article Joynson, B. W., & Ball, L. T. (2023). Skeletal Editing: Interconversion of Arenes and Heteroarenes. Helvetica Chimica Acta, https://doi.org/10.1002/hlca.202200182 meta-Selective C–H arylation of phenols via regiodiversion of electrophilic aromatic substitution (2022)Journal Article Senior, A., Ruffell, K., & Ball, L. T. (2022). meta-Selective C–H arylation of phenols via regiodiversion of electrophilic aromatic substitution. Nature Chemistry, https://doi.org/10.1038/s41557-022-01101-0 Umpolung Synthesis of Pyridyl Ethers by Bi(V)‐Mediated O‑Arylation of Pyridones (2022)Journal Article Ruffell, K., Gallegos, L., Ling, K., Paton, R. S., & Ball, L. T. (2022). Umpolung Synthesis of Pyridyl Ethers by Bi(V)‐Mediated O‑Arylation of Pyridones. Angewandte Chemie International Edition, Article e202212873. https://doi.org/10.1002/anie.202212873 Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/SN2-Displacement of Kukhtin–Ramirez Intermediates (2022)Journal Article Calcatelli, A., Denton, R. M., & Ball, L. T. (2022). Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/SN2-Displacement of Kukhtin–Ramirez Intermediates. Organic Letters, https://doi.org/10.1021/acs.orglett.2c03201 Bismuth-Mediated ?-Arylation of Acidic Diketones with ortho-Substituted Boronic Acids (2022)Journal Article Ruffell, K., Argent, S. P., Ling, K. B., & Ball, L. T. (2022). Bismuth-Mediated ?-Arylation of Acidic Diketones with ortho-Substituted Boronic Acids. Angewandte Chemie International Edition, 61(40), Article e202210840. https://doi.org/10.1002/anie.202210840 Generation of Thiyl Radicals from Air-Stable, Odorless Thiophenol Surrogates: Application to Visible-Light-Promoted C–S Cross-Coupling (2022)Journal Article Swan, C., Maggi, L., Park, M., Taylor, S., Shepherd, W., & Ball, L. T. (2022). Generation of Thiyl Radicals from Air-Stable, Odorless Thiophenol Surrogates: Application to Visible-Light-Promoted C–S Cross-Coupling. SYNTHESIS, 15(54), 3399-3408. https://doi.org/10.1055/s-0041-1737816 Phosphine-Catalyzed Aryne Oligomerization: Direct Access to ?,?-Bisfunctionalized Oligo(ortho-arylenes) (2021)Journal Article Bürger, M., Ehrhardt, N., Barber, T., Ball, L. T., Namyslo, J. C., Jones, P. G., & Werz, D. B. (2021). Phosphine-Catalyzed Aryne Oligomerization: Direct Access to α,ω-Bisfunctionalized Oligo(ortho-arylenes). Journal of the American Chemical Society, 143(40), 16796-16803. https://doi.org/10.1021/jacs.1c08689 Synthesis of tert-Alkyl Phosphines: Preparation of Di-(1-adamantyl)phosphonium Trifluoromethanesulfonate and Tri-(1-adamantyl)phosphine (2021)Journal Article Barber, T., & Ball, L. (2021). Synthesis of tert-Alkyl Phosphines: Preparation of Di-(1-adamantyl)phosphonium Trifluoromethanesulfonate and Tri-(1-adamantyl)phosphine. Organic Syntheses, 98, 289-314. https://doi.org/10.15227/orgsyn.098.0289 Bismuth(V)-Mediated C–H Arylation of Phenols and Naphthols (2020)Journal Article Senior, A., & Ball, L. T. (2021). Bismuth(V)-Mediated C–H Arylation of Phenols and Naphthols. SYNLETT, 32(03), 235-240. https://doi.org/10.1055/s-0040-1706294 Kinetic Analysis of Domino Catalysis: a Case Study on Gold-Catalyzed Arylation (2020)Journal Article Ball, L. T., Corrie, T., Cresswell, A., & Lloyd-Jones, G. C. (2020). Kinetic Analysis of Domino Catalysis: a Case Study on Gold-Catalyzed Arylation. ACS Catalysis, 10(18), 10420–10426. https://doi.org/10.1021/acscatal.0c03178 Organobismuth Redox Manifolds: Versatile Tools for Synthesis (2020)Journal Article Ruffell, K., & Ball, L. T. (2020). Organobismuth Redox Manifolds: Versatile Tools for Synthesis. Trends in Chemistry, 2(10), 867-869. https://doi.org/10.1016/j.trechm.2020.07.008 Expanding Ligand Space: Preparation, Characterization, and Synthetic Applications of Air-Stable, Odorless Di-tert-alkylphosphine Surrogates (2020)Journal Article Barber, T., Argent, S. P., & Ball, L. T. (2020). Expanding Ligand Space: Preparation, Characterization, and Synthetic Applications of Air-Stable, Odorless Di-tert-alkylphosphine Surrogates. ACS Catalysis, 10, 5454-5461. https://doi.org/10.1021/acscatal.0c01414 Polyurethanes and Polyallophanates via Sequence-Selective Copolymerization of Epoxides and Isocyanates (2020)Journal Article Jurrat, M., Pointer-Gleadhill, B. J., Ball, L. T., Chapman, A., & Adriaenssens, L. (2020). Polyurethanes and Polyallophanates via Sequence-Selective Copolymerization of Epoxides and Isocyanates. Journal of the American Chemical Society, https://doi.org/10.1021/jacs.0c03520 Modular bismacycles for the selective C–H arylation of phenols and naphthols (2020)Journal Article Jurrat, M., Maggi, L., Lewis, W., & Ball, L. T. (2020). Modular bismacycles for the selective C–H arylation of phenols and naphthols. Nature Chemistry, 12(3), 260-269. https://doi.org/10.1038/s41557-020-0425-4 Synthesis of air?stable, odorless thiophenol surrogates via Ni?Catalyzed C?S cross?coupling (2019)Journal Article Magné, V., & Ball, L. T. (2019). Synthesis of air‐stable, odorless thiophenol surrogates via Ni‐Catalyzed C−S cross‐coupling. Chemistry - A European Journal, 25(37), 8903-8910. https://doi.org/10.1002/chem.201901874 Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus ?-Complexation (2016)Journal Article Corrie, T. J., Ball, L. T., Russell, C. A., & Lloyd-Jones, G. C. (2017). Au-Catalyzed Biaryl Coupling To Generate 5- to 9-Membered Rings: Turnover-Limiting Reductive Elimination versus ?-Complexation. Journal of the American Chemical Society, 139(1), 245-254. https://doi.org/10.1021/jacs.6b10018 Self-control tames the coupling of reactive radicals (2014)Journal Article Lloyd-Jones, G. C., & Ball, L. T. (2014). Self-control tames the coupling of reactive radicals. Science, 345(6195), https://doi.org/10.1126/science.1256755 Gold-catalyzed oxidative coupling of arylsilanes and arenes: Origin of selectivity and improved precatalyst (2013)Journal Article Lloyd-Jones, G. C., Ball, L., & Russell, C. A. (2014). Gold-catalyzed oxidative coupling of arylsilanes and arenes: Origin of selectivity and improved precatalyst. Journal of the American Chemical Society, 136(1), 254-264.