Smith, Paul - University of Nottingham - School of Life Sciences

研究领域

Molecular pharmacology of somatostatin receptors: effects on cell metabolism and ion channel function The electrophysiology of adipocytes and the role of ion channels in their function. Regulation of the trafficking and expression of L-type Ca2+ channels in endocrine cells. Multi-electrode-array analysis of electrical behaviour in pancreatic b-cells. Real time recording of quantal peptide secretion from endocrine cells, identification of sequential and compound exoxytosis using amperometry, patch-clamp and mathematical techniques

近期论文

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ALMUKHTAR H, GARLE MJ, SMITH PA and ROBERTS RE, 2016. Effect of simvastatin on vascular tone in porcine coronary artery: Potential role of the mitochondria. Toxicology and applied pharmacology. 305, 176-185 ELMORSY, EKRAMY and SMITH, PAUL A., 2015. Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 460(3), 857-862 ELMORSY E, ELZALABANY LM, ELSHEIKHA HM and SMITH PA, 2014. Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier. Brain research. 1583, 255-68 BENTLEY DC, PULBUTR P, CHAN S and SMITH PA, 2014. Etiology of the membrane potential of rat white fat adipocytes. American journal of physiology. Endocrinology and metabolism. 307(2), E161-75 WHITE, B.J.O., SMITH, P.A. and DUNN, W.R., 2013. Hydrogen sulphide-mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats British Journal of Pharmacology. 168(4), 785-793 ELSHEIKHA, H.M., MCKINLEY C, ELSAIED, N.A. and SMITH, P.A., 2013. Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics Parasites & Vectors. 6(January), 24 VICKERY, H.S.F. and SMITH, P.A., 2012. Surface electromyography reveals males have a slower patellar reflex than females Journal of Electromyography and Kinesiology. 22(6), 990-996 WARD, D.R., DEAR, F.M., WARD, I.A., ANDERSON, S.I., SPERGEL, D.J., SMITH, P.A. and EBLING, F.J.P., 2009. Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse PLoS ONE. 4(4), e5322 SMITH, P.A., 2009. N-type Ca2+-channels in murine pancreatic β-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1 Endocrinology. 150(2), 741-748 ATHANASIOU, ANDRIANI, SMITH, PAUL A, VAKILPOUR, SARA, KUMARAN, NETHIA M, TURNER, AMY E, BAGIOKOU, DIMITRA, LAYFIELD, ROBERT, RAY, DAVID E, WESTWELL, ANDREW D, ALEXANDER, STEPHEN P H and KENDALL, DAVID A, 2007. Vanilloid receptor agonists and antagonists are mitochondrial inhibitors: how vanilloids cause non-vanilloid receptor mediated cell death. Biochemical and Biophysical Research Communications. 354(1), 50-5 ATHANASIOU, ANDRIANI, CLARKE, ANNA B, TURNER, AMY E, KUMARAN, NETHIA M, VAKILPOUR, SARA, SMITH, PAUL A, BAGIOKOU, DIMITRA, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, FANG, LIN, LOBO, DILEEP N and CONSTANTIN, 2007. Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochemical and biophysical research communications. 364(1), 131-7 DAUNT, M., DALE, O. and SMITH, P.A, 2006. Somatostatin inhibits oxidative respiration in pancreatic beta-cells. Endocrinology. 147(3), 1527-1535 SAGAR, D. R., SMITH, P. A., MILLNS, P. J., SMART, D., KENDALL, D. A. and CHAPMAN, V., 2004. TRPV1 and CB1 receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat European Journal of Neuroscience. 20(1), 175-184 VIRSOLVY, A., SMITH, P., BERTRAND, G., GROS, L., HÉRON, L., SALAZAR, G., PUECH, R. and BATAILLE, D, 2002. Block of Ca(2+)-channels by alpha-endosulphine inhibits insulin release. British Journal of Pharmacology. 135(7), 1810-8 SMITH, P A, SELLERS, L A and HUMPHREY, P P, 2001. Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells. Journal of Physiology. 532(1), 127-142 THOMAS, P and SMITH, P A, 2001. Tetrabutylammonium: a selective blocker of the somatostatin-activated hyperpolarizing current in mouse AtT-20 corticotrophs. Pflugers Archiv - European Journal of Physiology. 441(6), 816-23