个人简介

Senior Faculty Scientist Physical Biosciences Division, Lawrence Berkeley Lab (1991-Present) Advanced Light Source Professor Department of Applied Science, UC Davis (1991-Present) Physicist, National Synchrotron Light Source, Brookhaven National Lab (1988-1990) Member of Professional Staff Schlumberger-Doll Research (1986-1988) Senior Staff Chemist and Group Head, Exxon Research (1978-1986) California Institute of Technology - NIH post-doc with Prof. Harry Grayi (1978) Ph.D. Stanford University (1978) B.A. Williams College (1973)

研究领域

Analytical Chemistry/Environmental Chemistry/Inorganic Chemistry/Physical Chemistry

Stephen P. Cramer, whose research straddles the fields of synchrotron x-ray spectroscopy and bio-inorganic chemistry, is an Advanced Light Source Professor at UC Davis and Lawrence Berkeley National Laboratory. He became involved with synchrotron radiation in 1974, during thesis work on the EXAFS of nitrogenase at Stanford's SSRP. Following an NIH post-doc with Harry Gray, he joined Exxon Research, where he used EXAFS and other methods to characterize man-made and biological catalysts. Since then, he has worked on developing new synchrotron methods for characterizing metals in biology. These include the first bioinorganic applications of soft x-ray magnetic circular dichroism (XMCD) and resonant inelastic x-ray scattering (RIXS). More recently, his group has employed nuclear resonance vibrational spectroscopy (NRVS) and femtosecond pump probe spectroscopy (FPPS), as well conventional methods such as FT-IR, resonance Raman, and Mössbauer spectroscopy.

近期论文

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"A Hydride Bridge in Fully Reduced [NiFe] Hydrogenase –Evidence from Nuclear Resonance Vibrational Spectroscopy (NRVS) and DFT Calculations", Ogata, H.; Kraemer, T.; Hongxin Wang; Gastel, M. v.; Neese, F.; Rauchfuss, T.; Schilter, D.; Pelmenschikov, V.; Gee, L.; Aubrey Scott; Yoshitaka Yoda; Yoshito, T.; Lubitz, W.; Cramer, S. P. Nature Chem. Biol., 2014 "Nuclear resonance vibrational spectroscopy reveals the FeS cluster composition and active site vibrational properties of a NAD+-reducing [NiFe] hydrogenase", Lauterbach, L.; Wang, H.; Horch, M.; Gee, L. B.; Yoda, Y.; Tanaka, Y.; Zebger, I.; Lenz, O.; Cramer, S. Chem. Sci., 2014 submitted. "Structural Characterization of CO-Inhibited Mo-Nitrogenase by Combined Application of NRVS, EXAFS, and DFT: New Insights into the Effects of CO Binding and the Role of the Interstitial Atom", Scott, A.; Pelmenschikov, V.; Guo, Y.; Wang, H.; Yan, L.; George, S.; Dapper, C.; Newton, W.; Yoda, Y.; Tanaka, Y.; Cramer, S. P. J. Am. Chem. Soc., 2014 Accepted. "Synthesis and Vibrational Spectroscopy of 57Fe-Labeled Models of [NiFe] Hydrogenase: First Direct Observation of a Nickel-Iron Interaction" , Schilter, D.; Wang, H.; Pelmenschikov, V.; Gee, L. B.; Yoda, Y.; Cramer, S. P. Chem. Comm., 2014, 50, 13469-13472. "α-Hydroxy coordination of mononuclear vanadyl citrate, malate and S-citramalate with N−heterocycle ligand, implying a new protonation pathway of iron-vanadium cofactor in nitrogenase", Chen, C.-Y.; Chen, M.-L.; Chen, H.-B.; Wang, H.; Cramer, S. P.; Zhou, Z.-H. J. Inorg. Biochem., 2013, 141, 114-120. "A Practical Guide for Nuclear Resonance Vibrational Spectroscopy (NRVS) of Biochemical Samples and Model Compounds", Wang, H.; Alp, E. E.; Yoda, Y.; Cramer, S. P., in Metalloproteins: Methods and Protocols; Fontecilla-Camps, J. C. and Nicolet, Y., Ed.; Springer - Humana Press, 2014; Vol. 1122, pp. 125-138. "The HydG Enzyme Generates an Fe(CO)2(CN) Synthon in Assembly of the FeFe Hydrogenase H-Cluster", Kuchenreuther, J. M.; Myers, W. K.; Suess, D. L. M.; Stich, T. A.; Pelmenschikov, V.; Shiigi, S. A.; Cramer, S. P.; Swartz, J. R.; Britt, R. D.; George, S. J. Science, , 2014, 343, 424-427. "Fe-S Cluster Biogenesis in Gram-Positive Bacteria: SufU Is a Zinc-Dependent Sulfur Transfer Protein", Selbach, B. P.; Chung, A. H.; Scott, A. D.; George, S. J.; Cramer, S. P.; Dos Santos, P. C. Biochemistry, 2014, 53, 152-160. "Enantioselective Synthesis of Isotopically Labeled Homocitric Acid Lactone", Moore, J.; Hanhan, N.; Mahoney, M.; Cramer, S.; Shaw, J. Org. Lett., 2013, 15, 5615-5617. "Synchrotron Radiation Based Nuclear Resonant Scattering: Applications to Bioinorganic Chemistry", Guo, Y.; Yoda, Y.; Zhang, X.; Xiao, Y.; Cramer, S. P., in Mössbauer Spectroscopy: Applications in Chemistry, Biology, Industry, and Nanotechnology; Sharma, V. K., Klingelhofer, G. and Nishida, T., Ed.; Wiley, 2013, 20, 614-619. "Soft X-ray absorption spectroscopy and resonant inelastic X-ray scattering spectroscopy below 100 eV: probing first-row transition-metal M-edges in chemical complexes", Wang, H. X.; Young, A. T.; Guo, J. H.; Cramer, S. P.; Friedrich, S.; Braun, A.; Gu, W. W. J. Synchrotron Rad., 2013, 20, 614-619.