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2016. On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. (In Press.) M SLINGO, MA COLE, C CARR, M CURTIS, M DODD, L GILES, L HEATHER, D TYLER, K CLARKE and P ROBBINS, 2016. The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high energy phosphate metabolism American Journal of Physiology: Heart and Circulatory Physiology. (In Press.) MURRAY AJ, KNIGHT NS, COLE MA, COCHLIN LE, CARTER E, TCHABANENKO K, PICHULIK T, GULSTON MK, ATHERTON HJ, SCHROEDER MA, DEACON RM, KASHIWAYA Y, KING MT, PAWLOSKY R, RAWLINS JN, TYLER DJ, GRIFFIN JL, ROBERTSON J, VEECH RL and CLARKE K, 2016. Novel ketone diet enhances physical and cognitive performance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. (In Press.) MANSOR LS, MEHTA K, AKSENTIJEVIC D, CARR CA, LUND T, COLE MA, LE PAGE L, SOUSA FIALHO MDA L, SHATTOCK MJ, AASUM E, CLARKE K, TYLER DJ and HEATHER LC, 2015. Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. The Journal of physiology. 594(2), 307-20 HANDZLIK, MICHAL K., CONSTANTIN-TEODOSIU, DUMITRU, GREENHAFF, PAUL L. and COLE, MARK A., 2015. Augmented Cardiac Pyruvate Dehydrogenase Complex Flux During Hypoxia Increases Post-hypoxic Damage CIRCULATION RESEARCH. 117, MANSOR LS, GONZALEZ ER, COLE MA, TYLER DJ, BEESON JH, CLARKE K, CARR CA and HEATHER LC, 2013. Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin. Cardiovascular diabetology. 12, 136 HEATHER LC, PATES KM, ATHERTON HJ, COLE MA, BALL DR, EVANS RD, GLATZ JF, LUIKEN JJ, GRIFFIN JL and CLARKE K, 2013. Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion. Circulation. Heart failure. 6(5), 1058-66 HEATHER LC, COLE MA, TAN JJ, AMBROSE LJ, POPE S, ABD-JAMIL AH, CARTER EE, DODD MS, YEOH KK, SCHOFIELD CJ and CLARKE K, 2012. Metabolic adaptation to chronic hypoxia in cardiac mitochondria. Basic research in cardiology. 107(3), 268 STUCKEY, D. J., CARR, C. A., MEADER, S. J., TYLER, D. J., COLE, M. A. and CLARKE, K., 2011. First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart: Journal of Cardiovascular Magnetic Resonance Journal of Cardiovascular Magnetic Resonance. 13, COLE, M.A., MURRAY, A.J., COCHLIN, L.E., HEATHER, L.C., MCALEESE, S., KNIGHT, N.S., SUTTON, E., ABD JAMIL, A., PARASSOL, N. and CLARKE, K., 2011. A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart Basic Research in Cardiology. 106(3), 447-457 HEATHER LC, HOWELL NJ, EMMANUEL Y, COLE MA, FRENNEAUX MP, PAGANO D and CLARKE K, 2011. Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis. PloS one. 6(10), e26326 HEATHER, L.C., COLE, M.A., ATHERTON, H.J., COUMANS, W.A., EVANS, R.D., TYLER, D.J., GLATZ, J.F.C., LUIKEN, J.J.F.P. and CLARKE, K., 2010. Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart: Endocrinology Endocrinology. 151(1), 422-431 SCHROEDER, M.A., ATHERTON, H.J., BALL, D.R., COLE, M.A., HEATHER, L.C., GRIFFIN, J.L., CLARKE, K., RADDA, G.K. and TYLER, D.J., 2009. Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy FASEB Journal. 23(8), 2529-2538 HEATHER, L. C., CATCHPOLE, A. F., STUCKEY, D. J., COLE, M. A., CARR, C. A. and CLARKE, K., 2009. Isoproterenol Induces in Vivo Functional and Metabolic Abnormalities; Similar to Those Found in the Infarcted Rat Heart: Journal of Physiology and Pharmacology Journal of Physiology and Pharmacology. 60(3), 31-39 MURRAY, A.J., COLE, M.A., LYGATE, C.A., CARR, C.A., STUCKEY, D.J., LITTLE, S.E., NEUBAUER, S. and CLARKE, K., 2008. Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart Journal of Molecular and Cellular Cardiology. 44(4), 694-700