Chappell, Sally - University of Nottingham

个人简介

Sally Chappell gained her BSc in Biological Sciences (Genetics) from Birmingham in 1998, before moving to Nottingham to research the role of the angiotensinogen and angiotensin II receptor genes in normal and pre-eclamptic pregnancy for her PhD. This was followed by two post-doctoral positions concerned with the analysis of single nucleotide polymorphisms (SNPs) in Chronic Obstructive Pulmonary Disease (2001-2004; funded by the European Union), and paediatric liver disease in alpha-1-antitrypsin deficient individuals (2004-2006; funded by the Children's Liver Disease Foundation).

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IMELDA S BARBER, JENNYFER M. GARCíA-CáRDENAS, CHIDCHANOK SAKDAPANICHKUL, CHRISTOPHER DEACON, GABRIELA ZAPATA ERAZO, RITA GUERREIRO, JOSE BRAS, DENA HERNANDEZ, ANDREW SINGLETON, TAMAR GUETTA-BARANES, ANNE BRAAE, NAOMI CLEMENT, TULSI PATEL, KEELEY BROOKES, CHRISTOPHER MEDWAY, SALLY CHAPPELL, DAVID M. MANN, ARUK CONSORTIUM and KEVIN MORGAN, 2016. Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease Neurobiology of Aging. 39, 220.e1-220.e7 VICTORIA E JACKSON, IOANNA NTALLA, IAN SAYERS, RICHARD MORRIS, PETER WHINCUP, JUAN-PABLO CASAS, ANTOINETTE AMUZU, MINKYOUNG CHOI, CAROLINE DALE, MEENA KUMARI, JORGEN ENGMANN, NOOR KALSHEKER, SALLY CHAPPELL, TAMAR GUETTA-BARANES, TRICIA M MCKEEVER, COLIN NA PALMER, ROGER TAVENDALE, JOHN W HOLLOWAY, AVAN A SAYER, ELAINE M. DENNISON, CYRUS COOPER, MONA BAFADHEL, BETHAN BARKER, CHRIS BRIGHTLING, CHARLOTTE E BOLTON, MICHELLE E JOHN, STUART G PARKER, MIRIAM F MOFFAT, ANDREW J WARDLAW, MARTIN J CONNOLLY, DAVID J PORTEOUS, BLAIR H SMITH, SANDOSH PADMANABHAN, LYNNE HOCKING, KATHLEEN E STIRRUPS, PANOS DELOUKAS, DAVID P. STRACHAN, IAN P. HALL, MARTIN D TOBIN and LOUISE V WAIN, 2016. - Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12 Thorax. 71(6), 501-509 BROOKES, KJ, PATEL, T, ZAPATA-ERAZO, G, BARBER, I, BRAAE, A, GUETTA-BARANES, T, CHAPPELL, S and MORGAN, K, 2016. Identifying Polymorphisms in the Alzheimer's Related APP Gene Using the Minion Sequencer Journal of Next Generation Sequencing & Applications. 3(1), 125 WAIN LV, ODENTHAL-HESSE L, ABUJABER R, SAYERS I, BEARDSMORE C, GAILLARD EA, CHAPPELL S, DOGARU CM, MCKEEVER T, GUETTA-BARANES T, KALSHEKER N, KUEHNI CE, HALL IP, TOBIN MD and HOLLOX EJ, 2014. Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PloS one. 9(1), e84192 CHAPPELL SL, DALY L, LOTYA J, ALSAEGH A, GUETTA-BARANES T, ROCA J, RABINOVICH R, MORGAN K, MILLAR AB, DONNELLY SC, KEATINGS V, MACNEE W, STOLK J, HIEMSTRA PS, MINIATI M, MONTI S, O'CONNOR CM and KALSHEKER N, 2011. The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study BMC Medical Genetics. 12, 24 HAQ, IMRAN, CHAPPELL, SALLY, JOHNSON, SIMON R, LOTYA, JUZER, DALY, LESLIE, MORGAN, KEVIN, GUETTA-BARANES, TAMAR, ROCA, JOSEP, RABINOVICH, ROBERTO, MILLAR, ANN, DONNELLY, SEAMAS C, KEATINGS, VERA, MACNEE, WILLIAM, STOLK, JAN, HIEMSTRA, PIETER, MINIATI, MASSIMO, MONTI, SIMONETTA, O'CONNOR, CLARE and KALSHEKER, NOOR, 2010. Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12 in a European population. BMC Medical Genetics. 11(1), 7 MORGAN, K., CHAPPELL, S., GUETTA-BARANéS, T., MORLEY, S. and KALSHEKER, N., 2009. The alpha-1-antitrypsin gene promoter in human A549 lung derived cells, and a novel transcription initiation site International Journal of Biochemistry & Cell Biology. 41(5), 1157-1164 CHAPPELL, S., GUETTA-BARANéS, T., HADZIC, N., STOCKLEY, R. and KALSHEKER, N., 2009. Polymorphism in the endoplasmic reticulum mannosidase I (MAN1B1) gene is not associated with liver disease in individuals homozygous for the Z variant of the alpha1-antitrypsin protease inhibitor (PiZZ individuals) Hepatology. 50(4), 1315 KALSHEKER, NOOR and CHAPPELL, SALLY, 2008. The new genetics and chronic obstructive pulmonary disease. COPD. 5(4), 257-64 CHAPPELL, S., DALY, L., MORGAN, K., GUETTA-BARANES, T., ROCA, J., RABINOVICH, R., LOTYA, J., MILLAR, A.B., DONNELLY, S.C., KEATINGS, V., MACNEE, W., STOLK, J., HIEMSTRA, P.S., MINIATI, M., MONTI, S., O'CONNOR, C.M. and KALSHEKER, N., 2008. Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD European Respiratory Journal. 32(4), 931-937 CHAPPELL, S.L., HADZIC, N., STOCKLEY, R., GUETTA-BARANES, T., MORGAN, K. and KALSHEKER, N., 2008. A polymorphism of the alpha1-antitrypsin gene represents a risk factor for liver disease Hepatology. 47(1), 127-132 BELBIN, O., DUNN, J.L., CHAPPELL, S., RITCHIE, A.E., LING, Y., MORGAN, L., PRITCHARD, A., WARDEN, D.R., LENDON, C.L., LEHMANN, D.J., MANN, D.M.A., SMITH, A.D., KALSHEKER, N. and MORGAN, K., 2008. A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD Neurobiology of Aging. 29(8), 1167-1176 BELBIN, O., DUNN, J.L., LING, Y., MORGAN, L., CHAPPELL, S., BEAUMONT, H., WARDEN, D., SMITH, D.A., KALSHEKER, N. and MORGAN, K., 2007. Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease Human Molecular Genetics. 16(18), 2199-2208 BAKER, C., NIELSON, H.M., MINTHON, L., WRIGHT, H.T., CHAPPELL, S., OKYERE, J., MAY, S., MORGAN, K., KALSHEKER, N. and JANCIAUSKIENE, S.M., 2007. Effects of Alzheimer's peptide and α1-antichymotrypsin on astrocyte gene expression Neurobiology of Aging. 28(1), 51-61 PORCELLINI E, CALABRESE E, GUERINI F, GOVONI M, CHIAPPELLI M, TUMINI E, MORGAN K, CHAPPELL S, KALSHEKER N, FRANCESCHI M, LICASTRO F., 2007. The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration Neuroscience Letters. 416(1), 66-70 (In Press.) CHAPPELL, S., DALY, L., MORGAN, K., GUETTA-BARANES, T., ROCA, R., RABINOVICH, R., MILLAR, A., DONNELLY, S. C., KEATINGS, V., MACNEE, W., STOLK, J., HIEMSTRA, P. S., MINIATI, M., MONTI, S. and O'CONNOR, C, 2007. Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD European Respiratory Journal. 30(4), 810-812 CHAPPELL, S., DALY, L., MORGAN, K., BARANES, T.G., ROCA, J., RABINOVICH, R., MILLAR, A., DONNELLY, S.C., KEATINGS, V., MACNEE, W., STOLK, J., HIEMSTRA, P., MINIATI, M., MONTI, S., O'CONNOR, C.M. and KALSHEKER, N., 2006. Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease Human Mutation. 27(1), 103-109 TOWER, C., CHAPPELL, S., ACHARYA, M., CRANE, R., SZOLIN, S., SYMONDS, L., CHEVINS, H., KALSHEKER, N., BAKER, P. and MORGAN, L., 2006. Altered transmission of maternal angiotensin II receptor haplotypes in fetal growth restriction Human Mutation. 27(2), 138-144 CHAPPELL, S., DALY, L., MORGAN, K., BARANES, T.G., ROCA, J., RABINOVICH, R., MILLAR, A., DONNELLY, S.C., KEATINGS, V., MACNEE, W., STOLK, J., HIEMSTRA, P.S., MINIATI, M., MONTI, S., O'CONNOR, C.M. and KALSHEKER, N., 2006. The SERPINE2 gene and chronic obstructive pulmonary disease American Journal of Human Genetics. 79(1), 184-187 TOWER, C., CHAPPELL, S., KALSHEKER, N., BAKER, P. and MORGAN, L., 2006. Angiotensinogen gene variants and small-for-gestational-age infants BJOG: An International Journal of Obstetrics and Gynaecology. 113(3), 335-339 CHAPPELL, S. and MORGAN, L., 2006. Searching for genetic clues to the causes of pre-eclampsia Clinical Science. 110(4), 443-458 TOWER, C.L., CHAPPELL, S.L., MORGAN, K., KALSHEKER, N., BAKER, P.N. and MORGAN, L.J., 2005. Transforming growth factor β1 regulates angiotensin II type I receptor gene expression in the extravillous trophoblast cell line SGHPL-4 Molecular Human Reproduction. 11(12), 847-852 PLANT, B.J., GALLAGHER, C.G., BUCALA, R., BAUGH, J.A., CHAPPELL, S., MORGAN, L., O CONNOR, C.M., MORGAN, K. and DONNELLY, S.C., 2005. Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism American Journal of Respiratory and Critical Care Medicine. 172(11), 1412-1415 PLUMMER, S., TOWER, C., ALONSO, P., MORGAN, L., BAKER, P., BROUGHTON-PIPKIN, F. and KALSHEKER, N., 2004. Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia Human Mutation. 24(1), 14-20 CHAPPELL, S., GUETTA-BARANéS, T., BATOWSKI, K., YIANNAKIS, E., MORGAN, K., O'CONNOR, C., MACNEE, W. and KALSHEKER, N., 2004. Haplotypes of the alpha-1 antitrypsin gene in healthy controls and Z deficiency patients Human Mutation. 24(6), 535-536