Bolt, Ed - University of Nottingham - School of Life Sciences

个人简介

University of London: BSc. & PhD 1989-1995 Wellcome Trust Research Career development Fellowship, University of Nottingham 2002-2006 University Lecturer/Assistant Professor, University of Nottingham 2006-present

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MAJSEC K, BOLT EL and IVAN?I?-BA?E I, 2016. Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS. BMC microbiology. 16, 28 NORTHALL SJ, IVAN?I?-BA?E I, SOULTANAS P and BOLT EL, 2016. Remodeling and Control of Homologous Recombination by DNA Helicases and Translocases that Target Recombinases and Synapsis. Genes. 7(8), BOLT, EDWARD L., JENKINS, TABITHA, RUSSO, VALERIA MOREIRA, AHMED, SHARLENE, CAVEY, JAMES and CASS, SIMON D., 2016. Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair BIOSCIENCE REPORTS. 36, CASS SD, HAAS KA, STOLL B, ALKHNBASHI O, SHARMA K, URLAUB H, BACKOFEN R, MARCHFELDER A and BOLT EL, 2015. The role of Cas8 in type I CRISPR interference BioScience Reports. 35(3), e00197 ROLLIE, CLARE, SCHNEIDER, STEFANIE, BRINKMANN, ANNA SOPHIE, BOLT, EDWARD L and WHITE, MALCOLM F, 2015. Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition. eLife. 4, IVANA IVANCIC-BACE, SIMON D CASS, STEPHEN J WEARNE and EDWARD L BOLT, 2015. Different genome stability proteins underpin primed and na?ve adaptation in E. coli CRISPR-Cas immunity. Nucleic Acids Research. EL BOLT, T JENKINS, S CASS, J CAVEY and S AHMED, 2015. Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C reistance factors implicated in DNA repair BioScience Reports. CASS SD, HAAS KA, STOLL B, ALKHNBASHI OS, SHARMA K, URLAUB H, BACKOFEN R, MARCHFELDER A and BOLT EL, 2015. The role of Cas8 in type I CRISPR interference. Bioscience reports. 35(3), GONG B, SHIN M, SUN J, JUNG CH, BOLT EL, VAN DER OOST J and KIM JS, 2014. Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3. Proceedings of the National Academy of Sciences of the United States of America. 111(46), 16359-64 IVAN?I?-BA?E, I., RADOV?I?, M., BO?KOR, L., HOWARD, J.L. and BOLT, E.L., 2013. Cas3 stimulates runaway replication of a ColE1 plasmid in Escherichia coli and antagonises RNaseHI RNA Biology. 10(5), 35-43 IVAN?I?-BA?E I, AL HOWARD J and BOLT EL, 2012. Tuning in to interference: R-loops and Cascade complexes in CRISPR immunity.: Pubmed 22743103 Journal of Molecular Biology. HOWARD, J.A.L., DELMAS, S., IVAN?I??BA?E, I. and BOLT, E.L., 2011. Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein Biochemical Journal. 439(1), 85-95 WOODMAN, I.L., BRAMMER, K. and BOLT, E.L., 2011. Physical interaction between archaeal DNA repair helicase Hel308 and Replication Protein A (RPA) DNA Repair. 10(3), 306-313 MATILLA, I., ALFONSO, C., RIVAS, G., BOLT, E.L., DE LA CRUZ, F. and CABEZON, E., 2010. The conjugative DNA translocase TrwB is a structure-specific DNA-binding protein The Journal of Biological Chemistry. 285(23), 17537-17544 MACHWE,, XIAO,, LLOYD,, BOLT, and ORREN,, 2007. Replication fork regression in vitro by the Werner syndrome protein (WRN): Holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity. Nucleic Acids Research. 35(17), 5729-47 WOODMAN, ISABEL L, BRIGGS, GEOFFREY S and BOLT, EDWARD L, 2007. Archaeal Hel308 domain V couples DNA binding to ATP hydrolysis and positions DNA for unwinding over the helicase ratchet. Journal Molecular Biology. 374(5), 1139-44 MACMASTER, R, SEDELNIKOVA, S, BAKER, P.J, BOLT, E.L, LLOYD, R.G and RAFFERTY, J.B., 2006. RusA Holliday junction resolvase: DNA complex structure—insights into selectivity and specificity Nucleic Acids Research. 34(19), 5577–5584 GUY, C.P., HALDENBY, S., BRINDLEY, A., WALSH, D.A., BRIGGS, G.S., WARREN, M.J., ALLERS, T. and BOLT, E.L., 2006. Interactions of RadB, a DNA repair protein in archaea, with DNA and ATP Journal of Molecular Biology. 358(1), 46-56 GUY, C.P. and BOLT, E.L., 2005. Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands Nucleic Acids Research. 33(11), 3678-3690 BOLT, E. L., 2005. Helicases that interact with replication forks: new candidates from archaea Biochemical Society Transactions. VOL 33(PART 6), 1471-1473 GUY, C.P., MAJERNIK, A.I., CHONG, J.P.J. and BOLT, E.L., 2004. A novel nuclease-ATPase (Nar71) from archaea is part of a proposed thermophilic DNA repair system Nucleic Acids Research. 32(21), 6176-6186 SHARPLES, G. J., CURTIS, F. A., MCGLYNN, P. and BOLT, E. L., 2004. Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage l Journal of Molecular Biology. VOL 340(NUMBER 4), 739-751 RAFFERTY, J.B., BOLT, E.L., MURANOVA, T.A., SEDELNIKOVA, S.E., LEONARD, P., PASQUO, A., BAKER, P.J., RICE, D.W., SHARPLES, G.J. and LLOYD, R.G., 2003. The structure of Escherichia coli RusA endonuclease reveals a new Holliday junction DNA binding fold Structure. 11(12), 1557-1567 MURANOVA, T A., SEDELNIKOVA, S.E., LEONARD, P.M., PASQUO, A., BOLT, E.L., LLOYD, R.G. and RAFFERTY, J.B., 2003. Crystallization of RusA Holliday junction resolvase from Escherichia coli Acta Crystallographica. Section D: Biological Crystallography. 59(12), 2262-2264 BOLT, E. L. and GUY, C. P., 2003. Homologous recombination in Archaea: new Holliday junction helicases Biochemical Society Transactions. VOL 31(PART 3), 703-705