Bellamy, Tomas - University of Nottingham

研究领域

The major interest of our group is in understanding the role of bi-directional communication between neurons and glia in brain physiology. Specifically, we are interested in how information contained in neuronal network activity is encoded by astrocytes into calcium signals, with particular emphasis on the importance of kinetics in signal transduction. To that end, we use the cerebellum - a region of the brain involved in motor coordination and learning - to study the spatiotemporal properties of the glutamate and nitric oxide signalling pathways in astrocytes. We are also interested in the consequences of astrocyte calcium signalling on neuronal network function, focussing on how astrocytes can modulate synaptic strength.

近期论文

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CROFT, WAYNE, REUSCH, KATHARINA, TILUNAITE, AGNE, RUSSEL, NOAH, THUL, RüDIGER and BELLAMY, TOMAS C., 2016. Probabilistic encoding of stimulus strength in astrocyte global calcium signals Glia. 64(4), 537–552 DOBSON K.L., JACKSON C., BALAKRISHNAN S. and BELLAMY T.C., 2015. Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling. PloS one. 10(5), e0125974 CROFT, WAYNE, DOBSON, KATHARINE L. and BELLAMY, TOMAS C., 2015. Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity NEURAL PLASTICITY. BELLAMY, TOMAS C., DUNAEVSKY, ANNA and PARRI, H. RHEINALLT, 2015. Glial Plasticity NEURAL PLASTICITY. BELLAMY TC, DUNAEVSKY A and PARRI HR, 2015. Glial Plasticity. Neural plasticity. 2015, 723891 CROFT W, DOBSON KL and BELLAMY TC, 2015. Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity. Neural plasticity. 2015, 765792 DOBSON KL and BELLAMY TC, 2015. Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. Neural plasticity. 2015, 602356 REUSCH K, RUSSELL NA and BELLAMY TC, 2014. Stimulus discrimination in cerebellar Purkinje neurons. PloS one. 9(2), e87828 BALAKRISHNAN S, DOBSON KL, JACKSON C and BELLAMY TC, 2014. Ectopic release of glutamate contributes to spillover at parallel fibre synapses in the cerebellum. The Journal of Physiology. 592(Pt 7), 1493-503 JAMES, L.R., ANDREWS, S., WALKER S, DE SOUSA, P.R.S., RAY, A., RUSSELL, N.A. and BELLAMY, T.C., 2011. High-throughput analysis of calcium signalling kinetics in astrocytes stimulated with different neurotransmitters PLoS ONE. 6(10), e26889 BALAKRISHNAN, S., JACKSON, C., RUSSELL, N. and BELLAMY, T.C., 2011. Ectopic release sites lack fast vesicle recycling mechanisms, causing long-term depression of neuron-glial transmission in rat cerebellum Glia. 59(1), 82-93 NEWTON, M, NIEWCZAS, I, CLARK, J and AND BELLAMY, T.C., 2010. A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase. Analytical Biochemistry. 402, 129-136 JACKSON, C., WELCH, H.C. and BELLAMY, T.C., 2010. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase PLoS One. 5(8), e11962 BALAKRISHNAN, S. and BELLAMY, T.C., 2009. Depression of parallel and climbing fiber transmission to Bergmann glia is input specific and correlates with increased precision of synaptic transmission Glia. 57(4), 393-401 JAMES, L.R., GRIFFITHS, C.H., GARTHWAITE, J. and BELLAMY, T.C., 2009. Inhibition of nitric oxide-activated guanylyl cyclase by calmodulin antagonists British Journal of Pharmacology. 158(6), 1454-1464 THUL, R, BELLAMY, TC, RODERICK, HL, BOOTMAN, MD and COOMBES, S, 2008. Calcium Oscillations Cellular Oscillatory Mechanisms. 641, 1-27 BELLAMY, TC, 2007. Presynaptic Modulation Of Parallel Fibre Signalling To Bergmann Glia Neuropharmacology. 52(2), 368-375 BELLAMY, T.C., 2006. Interactions between Purkinje neurones and Bergmann glia. Cerebellum. 5, 116-126 BELLAMY, TC and OGDEN, D, 2006. Long-Term Depression Of Neuron To Glial Signalling In Rat Cerebellar Cortex European Journal Of Neuroscience. 23(2), 581-586 BELLAMY, TC and OGDEN, D, 2005. Short-Term Plasticity Of Bergmann Glial Cell Extrasynaptic Currents During Parallel Fiber Stimulation In Rat Cerebellum Glia. 52(4), 325-335 GRIFFITHS, C, WYKES, V, BELLAMY, TC and GARTHWAITE, J, 2003. A New And Simple Method For Delivering Clamped Nitric Oxide Concentrations In The Physiological Range: Application To Activation Of Guanylyl Cyclase-Coupled Nitric Oxide Receptors Molecular Pharmacology. 64(6), 1349-1356 WYKES, V, BELLAMY, TC and GARTHWAITE, J, 2002. Kinetics Of Nitric Oxide-Cyclic Gmp Signalling In Cns Cells And Itspossible Regulation By Cyclic Gmp Journal Of Neurochemistry. 83(1), 37-47 BELLAMY, TC, GRIFFITHS, C and GARTHWAITE, J, 2002. Differential Sensitivity Of Guanylyl Cyclase And Mitochondrial Respiration To Nitric Oxide Measured Using Clamped Concentrations Journal Of Biological Chemistry. 277(35), 31801-31807 BELLAMY, TC and GARTHWAITE, J, 2002. Pharmacology Of The Nitric Oxide Receptor, Soluble Guanylyl Cyclase, In Cerebellar Cells British Journal Of Pharmacology. 136(1), 95-103 BELLAMY, TC and GARTHWAITE, J, 2002. The Receptor-Like Properties Of Nitric Oxide-Activated Soluble Guanylyl Cyclase In Intact Cells Molecular And Cellular Biochemistry. 230(1-2), 165-176