Wickstead, Bill - University of Nottingham

研究领域

My research interests include genome architecture, chromosome segregation, molecular motor function and multigene-family evolution. The uniting factor behind these topics is the importance they have to understanding the biology of the parasite Trypanosoma brucei. Much of the research in the lab also integrates bioinformatic and mathematical tools with wet-bench work. The use of these tools - particularly in an age where so much genomic information is becoming available - can greatly speed-up biological research and help us to ask the right questions of the systems we study.

近期论文

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PATEL JT, BELSHAM HR, RATHBONE AJ, WICKSTEAD B, GELL C and FRIEL CT, 2016. The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition. Open biology. 6(10), D'ARCHIVIO S and WICKSTEAD B, 2016. Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes. The Journal of cell biology. (In Press.) RACHEL, R.A., YAMAMOTO, E.A., DEWANJEE, M.K., MAY-SIMERA, H.L., SERGEEV, Y.V., HACKETT, A.N., POHIDA, K., MUNASINGHE, J., GOTOH, N., WICKSTEAD, B., FARISS, R.N., DONG, L., LI, T. and SWAROOP, A., 2015. CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies. Hum Mol Genet. 24(13), 3775-3791 ROQUES, M., WALL, R.J., DOUGLASS, A.P., RAMAPRASAD, A., FERGUSON, D.J., KAINDAMA, M.L., BRUSINI, L., JOSHI, N., RCHIAD, Z., BRADY, D., GUTTERY, D.S., WHEATLEY, S.P., YAMANO, H., HOLDER, A.A., PAIN, A., WICKSTEAD, B. and TEWARI, R., 2015. Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes. PLoS Pathog. 11(11), e1005273 GADELHA, C., ZHANG, W., CHAMBERLAIN, J.W., CHAIT, B.T., WICKSTEAD, B. and FIELD, M.C., 2015. Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics. Mol Cell Proteomics. 14(7), 1911-1926 GADELHA C, ZHANG W, CHAMBERLAIN JW, CHAIT BT, WICKSTEAD B and FIELD MC, 2015. Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics. Molecular & cellular proteomics : MCP. 14(7), 1911-26 STANNE TM, NARAYANAN MS, RIDEWOOD S, LING A, WITMER K, KUSHWAHA M, WIESLER S, WICKSTEAD B, WOOD J and RUDENKO G, 2015. Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei. The Journal of biological chemistry. 290(45), 26954-67 GUTTERY DS, POULIN B, RAMAPRASAD A, WALL RJ, FERGUSON DJP, BRADY D, PATZEWITZ E, WHIPPLE S, STRASCHIL U, WRIGHT MH, MOHAMED AMAH, RADHAKRISHNAN A, AROLD ST, TATE EW, HOLDER AA, WICKSTEAD B, PAIN A and TEWARI R, 2014. Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell host & microbe. 16(1), 128-40 CROSS GAM, KIM H and WICKSTEAD B, 2014. Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427. Molecular and biochemical parasitology. 195(1), 59-73 POULIN B, PATZEWITZ E, BRADY D, SILVIE O, WRIGHT MH, FERGUSON DJP, WALL RJ, WHIPPLE S, GUTTERY DS, TATE EW, WICKSTEAD B, HOLDER AA and TEWARI R, 2013. Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biology open. 2(11), 1160-70 WHEELER RJ, SCHEUMANN N, WICKSTEAD B, GULL K and VAUGHAN S, 2013. Cytokinesis in Trypanosoma brucei differs between bloodstream and tsetse trypomastigote forms: implications for microtubule-based morphogenesis and mutant analysis. Molecular microbiology. 90(6), 1339-55 DE LEON JC, SCHEUMANN N, BEATTY W, BECK JR, TRAN JQ, YAU C, BRADLEY PJ, GULL K, WICKSTEAD B and MORRISSETTE NS, 2013. A SAS-6-like protein suggests that the Toxoplasma conoid complex evolved from flagellar components. Eukaryotic cell. 12(7), 1009-19 GUTTERY, D.S., POULIN, B., FERGUSON, D.J.P., SZ??R, B., WICKSTEAD, B., CARROLL, P.L., RAMAKRISHNAN, C., BRADY, D., PATZEWITZ, E.-M., STRASCHIL, U., SOLYAKOV, L., GREEN, J.L., SINDEN, R.E., TOBIN, A.B., HOLDER, A.A. and TEWARI, R., 2012. A unique protein phosphatase with kelch-like domains (ppkl) in Plasmodium modulates ookinete differentiation, motility and invasion PLOS Pathogens. 8(9), e1002948 DANIELS, J.P., GULL, K. and WICKSTEAD, B., 2012. The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function. Eukaryot Cell. 11(5), 662-672 HODGES, M.E., WICKSTEAD, B., GULL, K. and LANGDALE, J.A., 2012. The evolution of land plant cilia. New Phytol. 195(3), 526-540 SUNTER, J., WICKSTEAD, B., GULL, K. and CARRINGTON, M., 2012. A new generation of T7 RNA polymerase-independent inducible expression plasmids for Trypanosoma brucei. PLoS One. 7(4), e35167 KELLY, S., WICKSTEAD, B. and GULL, K., 2011. Archaeal phylogenomics provides evidence in support of a methanogenic origin of the Archaea and a thaumarchaeal origin for the eukaryotes Proceedings of the Royal Society. B, Biological Sciences. 278(1708), 1009-1018 WICKSTEAD, B. and GULL, K., 2011. The evolution of the cytoskeleton Journal of Cell Biology. 194(4), 513-525 WICKSTEAD, BILL and GULL, KEITH, 2011. The evolutionary biology of dyneins. In: KING, STEPHEN, ed., Dyneins: Structure, biology and disease Academic Press. 88-121 HODGES, MATTHEW E, WICKSTEAD, BILL, GULL, KEITH and LANGDALE, JANE A, 2011. Conservation of ciliary proteins in plants with no cilia BMC Plant Biol. 11(1), 185 WICKSTEAD, BILL, CARRINGTON, JAMIE T, GLUENZ, EVA and GULL, KEITH, 2010. The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles. PloS one. 5(11), e15020 WICKSTEAD, B, GULL, K. and RICHARDS, T.A., 2010. Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton BMC Evolutionary Biology. 10, 110 HODGES, M.E., SCHEUMANN, N., WICKSTEAD, B., LANGDALE, J.A. and GULL, K., 2010. Reconstructing the evolutionary history of the centriole from protein components Journal of Cell Science. 123(9), 1407-1413 DANIELS, JAN-PETER, GULL, KEITH and WICKSTEAD, BILL, 2010. Cell biology of the trypanosome genome. Microbiology and molecular biology reviews : MMBR. 74(4), 552-69 DANIELS, JAN-PETER, KELLY, STEVEN, WICKSTEAD, BILL and GULL, KEITH, 2009. Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea. Biology direct. 4, 24