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个人简介

BSc (Microbiology, with intercalated year), University of Warwick (2000); Research Technician, PPL Therapeutics Ltd (1999); PhD, Imperial College, London (2004); Research Assistant, Wellcome Trust Sanger Institute (2004-5); Research Fellow, Massachusetts General Hospital and Harvard Medical School (2005-2011).

研究领域

I am interested in the role of autophagy in sensing and controlling bacterial infection. Many intracellular bacteria are targeted and destroyed by autophagy and we would like to know how the cell senses their presence and the bacterial strategies for autophagy avoidance.

近期论文

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HUETT, A., HEATH, R.J., BEGUN, J., SASSI, S.O., BAXT, L.A., VYAS, J.M., GOLDBERG, M.B. and XAVIER, R.J., 2012. The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella typhimurium Cell Host and Microbe. 12(6), 778-790 STAPPENBECK TS, RIOUX JD, MIZOGUCHI A, SAITOH T, HUETT A, DARFEUILLE-MICHAUD A, WILEMAN T, MIZUSHIMA N, CARDING S, AKIRA S, PARKES M and XAVIER RJ, 2011. Crohn Disease: A Current Perspective On Genetics, Autophagy And Immunity. Autophagy. 7(4), 355-74 NG, A.C.Y., EISENBERG, J.M., HEATH, R.J.W., HUETT, A., ROBINSON, C.M., NAU, G.J. and XAVIER, R.J., 2011. Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity Proceedings of the National Academy of Sciences of the United States of America. 108(Supplement 1), 4631-4638 HUETT A, GOEL G and XAVIER RJ, 2010. A Systems Biology Viewpoint On Autophagy In Health And Disease. Current Opinion In Gastroenterology. 26(4), 302-9 LAPAQUETTE P, GLASSER A, HUETT A, XAVIER RJ and DARFEUILLE-MICHAUD A, 2010. Crohn's Disease-Associated Adherent-Invasive E. Coli Are Selectively Favoured By Impaired Autophagy To Replicate Intracellularly. Cellular Microbiology. 12(1), 99-113 HUETT A and XAVIER RJ, 2010. Autophagy At The Gut Interface: Mucosal Responses To Stress And The Consequences For Inflammatory Bowel Diseases. Inflammatory Bowel Diseases. 16(1), 152-74 HUETT A and XAVIER R, 2009. Building Complex Biological Networks Based Upon Model Organisms: Mapping The Human Autophagy Interactome Via A Hybrid Yeast-Human Protein Interaction Network. Autophagy. 5(6), 884-6 HUETT A, LEONG JM, PODOLSKY DK and XAVIER RJ, 2009. The Cytoskeletal Scaffold Shank3 Is Recruited To Pathogen-Induced Actin Rearrangements. Experimental Cell Research. 315(12), 2001-11 HUETT, A., NG, A., CAO, Z., KUBALLA, P., KOMATSU, M., DALY, M.J., PODOLSKY, D.K. and XAVIER, R.J., 2009. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. The Journal Of Immunology. 182(8), 4917-4930 HUETT A, MCCARROLL SA, DALY MJ and XAVIER RJ, 2009. On The Level: Irgm Gene Function Is All About Expression. Autophagy. 5(1), 96-9 MCCARROLL, S.A., HUETT, A., KUBALLA, P., CHILEWSKI, S.D., LANDRY, A., GOYETTE, P., ZODY, M.C., HALL, J.L., BRANT, S.R., CHO, J.H., DUERR, R.H., SILVERBERG, M.S., TAYLOR, K.D., RIOUX, J.D., ALTSHULER, D., DALY, M.J. and XAVIER, R.J., 2008. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease Nature Genetics. 40(9), 1107-1112 KUBALLA P, HUETT A, RIOUX JD, DALY MJ and XAVIER RJ, 2008. Impaired Autophagy Of An Intracellular Pathogen Induced By A Crohn's Disease Associated Atg16l1 Variant. Plos One. 3(10), e3391 HUETT A and XAVIER RJ, 2008. Neither Hide Nor Hair: The Difficulty Of Identifying Useful Disease Biomarkers. Gastroenterology. 134(7), 2164-8 XAVIER RJ, HUETT A and RIOUX JD, 2008. Autophagy As An Important Process In Gut Homeostasis And Crohn's Disease Pathogenesis. Gut. 57(6), 717-20 CAO Z, HUETT A, KUBALLA P, GIALLOURAKIS C and XAVIER RJ, 2008. Dlg1 Is An Anchor For The E3 Ligase March2 At Sites Of Cell-Cell Contact. Cellular Signalling. 20(1), 73-82 HUETT A and XAVIER R, 2008. Snpping Away At The Pathogenesis Of Crohn's Disease. Inflammatory Bowel Diseases. 14(1), 136-7 STEPHENSON LM, SAMMUT B, GRAHAM DB, CHAN-WANG J, BRIM KL, HUETT AS, MILETIC AV, KLOEPPEL T, LANDRY A, XAVIER R and SWAT W, 2007. Dlgh1 Is A Negative Regulator Of T-Lymphocyte Proliferation. Molecular And Cellular Biology. 27(21), 7574-81 RIOUX JD, XAVIER RJ, TAYLOR KD, SILVERBERG MS, GOYETTE P, HUETT A, GREEN T, KUBALLA P, BARMADA MM, DATTA LW, SHUGART YY, GRIFFITHS AM, TARGAN SR, IPPOLITI AF, BERNARD E, MEI L, NICOLAE DL, REGUEIRO M, SCHUMM LP, STEINHART AH, ROTTER JI, DUERR RH, CHO JH, DALY MJ and BRANT SR, 2007. Genome-Wide Association Study Identifies New Susceptibility Loci For Crohn Disease And Implicates Autophagy In Disease Pathogenesis. Nature Genetics. 39(5), 596-604 LI CKF, PENDER SLF, PICKARD KM, CHANCE V, HOLLOWAY JA, HUETT A, GONÇALVES NS, MUDGETT JS, DOUGAN G, FRANKEL G and MACDONALD TT, 2004. Impaired Immunity To Intestinal Bacterial Infection In Stromelysin-1 (Matrix Metalloproteinase-3)-Deficient Mice. Journal Of Immunology (Baltimore, Md. : 1950). 173(8), 5171-9 WILES S, CLARE S, HARKER J, HUETT A, YOUNG D, DOUGAN G and FRANKEL G, 2004. Organ Specificity, Colonization And Clearance Dynamics In Vivo Following Oral Challenges With The Murine Pathogen Citrobacter Rodentium. Cellular Microbiology. 6(10), 963-72 BOWE F, LAVELLE EC, MCNEELA EA, HALE C, CLARE S, ARICO B, GIULIANI MM, RAE A, HUETT A, RAPPUOLI R, DOUGAN G and MILLS KHG, 2004. Mucosal Vaccination Against Serogroup B Meningococci: Induction Of Bactericidal Antibodies And Cellular Immunity Following Intranasal Immunization With Nada Of Neisseria Meningitidis And Mutants Of Escherichia Coli Heat-Labile Enterotoxin. Infection And Immunity. 72(7), 4052-60 SIMMONS CP, CLARE S, GHAEM-MAGHAMI M, UREN TK, RANKIN J, HUETT A, GOLDIN R, LEWIS DJ, MACDONALD TT, STRUGNELL RA, FRANKEL G and DOUGAN G, 2003. Central Role For B Lymphocytes And Cd4+ T Cells In Immunity To Infection By The Attaching And Effacing Pathogen Citrobacter Rodentium. Infection And Immunity. 71(9), 5077-86 CLARE S, HUETT A and DOUGAN G, 2002. Host/Pathogen Interactions At Mucosal Surfaces: Immune Consequences. Research In Microbiology. 153(7), 455-9 DOUGAN G, HUETT A and CLARE S, 2002. Vaccines Against Human Enteric Bacterial Pathogens. British Medical Bulletin. 62, 113-23 HUETT AS, INNES DA, MOORE MJ, SCHNIEKE AE and SHIELS PG, 1999. Identification Of A Novel Haeiii Pcr-Rflp In The Sla Dqb Gene. Animal Genetics. 30(5), 397

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