个人简介

Dreyfus Award (1989-1994) Appointed to faculty, UC Davis (1989) M.A., Ph.D., University of California, Berkeley (1980) B.S., North Carolina State University, (1978)

研究领域

Bioinorganic Chemistry/Biophysical Chemistry/Chemical Biology/Physical Chemistry

The Britt group's research focuses on the biological chemistry enabled by transition metals and amino acid and cofactor radicals. Much of our work is directed towards photosynthesis, particularly the Photosystem II oxygen evolving complex, which harnesses the energy of visible light photons to split water, producing molecular oxygen and biologically activated electrons and protons. This chemistry occurs in a catalytic complex containing a tetranuclear cluster of high valence manganese ions and a photogenerated tyrosine amino acid radical, along with essential Cl- and Ca2+ cofactors. Other current research interests include the function of Photosystem I, cytochrome c oxidase, manganese catalase, and the biological roles of vanadium. We are also exploring the binding of metal ions to nucleic acids and how such metal centers are involved in ribozyme catalytic function.

近期论文

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Biochemical and EPR-Spectroscopic Investigation into Heterologously Expressed Vinyl Chloride Reductive Dehalogenase (VcrA) from Dehalococcoides mccartyi Strain VS Anutthaman Parthasarathy, Troy A. Stich, Svenja T. Lohner, Ann Lesnefsky, R. David Britt, and Alfred M. Spormann JACS Just Accepted. X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly Pedro Dinis, Daniel L. M. Suess, Stephen J. Fox, Jenny E. Harmer, Rebecca C. Driesener, Liliana De La Paz, James R. Swartz, Jonathan W. Essex, R. David Britt, and Peter L. Roach PNAS Just Accepted. Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced EPR Spectroscopic Analysis Derek M. Gagnon, Megan Brunjes Brophy, Sarah E. J. Bowman, Troy A. Stich, Catherine L. Drennan, R. David Britt, and Elizabeth M. Nolan J. Am. Chem. Soc. Just Accepted. Metal ion oxidation state assignment based on coordinating ligand hyperfine interaction Paul H. Oyala, Troy A. Stich, and R. David Britt Photosynthesis Research Just Accepted. Pulse EPR studies of the interaction of methanol with the S2 state of the Mn4O5Ca cluster of Photosystem II Paul H. Oyala, Troy A. Stich, Jamie A. Stull, Fangting Yu, Vincent L. Pecoraro, and R. David Britt Biochemistry Just Accepted. The Cyanide Ligands of [FeFe] Hydrogenase: Pulse EPR Studies of 13C and 15N-Labeled H-Cluster William K. Myers, Troy A. Stich, Daniel L. M. Suess, Jon M. Kuchenreuther, James R. Swartz, and R. David Britt J. Am. Chem. Soc. 136, 12237–12240. One step closer to O2 R. David Britt and Paul H. Oyala Science. 345, 736. A Perspective on Electronic structure of the oxygen-evolving complex in photosystem II prior to O-O bond formation by Nicholas Cox and coworkers. Paramagnetic Intermediates Generated by Radical S‑Adenosylmethionine (SAM) Enzymes Troy A. Stich, William K. Myers, and R. David Britt Accounts of Chemical Research. 47, 2235–2243. The reduction rates of DEPC-modified mutant Thermus thermophilus Rieske proteins differ when there is a negative charge proximal to the cluster Nicholas E. Karagas, Christie N. Jones, Deborah J. Osborn, Anika L. Dzierlenga, Paul Oyala, Mary E. Konkle, Emily M. Whitney, R. David Britt, and Laura M. Hunsicker-Wang Journal of Biological Inorganic Chemistry. 19, 1121-1135. The HydG Enzyme Generates an Fe(CO)2(CN) Synthon in Assembly of the FeFe Hydrogenase H-Cluster Jon M. Kuchenreuther, William K. Myers, Daniel L.M. Suess, Troy A. Stich, Vladimir Pelmenschikov, Stacey A. Shiigi, Stephen P. Cramer, James R. Swartz, R. David Britt, and Simon J. George Science 343, 424-427. Perspective by Chris Pickett Radical Intermediate in Tyrosine Scission to the CO and CN− Ligands of [FeFe] Hydrogenase Jon M. Kuchenreuther, William K. Myers, Troy A. Stich, Simon J. George, Yaser NejatyJahromy, James R. Swartz, and R. David Britt Science 342, 472-475. Double Electron-Electron Resonance Probes Ca2+-induced Conformational Changes and Dimerization of Recoverin William K. Myers, Xianzhong Xu, Congmin Li, Jens O. Lagerstedt, Madhu S. Budamagunta, John C. Voss, R. David Britt, and James B. Ames Biochemistry 52, 5800–5808. The conformation of P450cam in complex with putidaredoxin is dependent on oxidation state William K. Myers, Young-Tae Lee, R. David Britt, and David B. Goodin J. Am. Chem. Soc. 135, 11732–11735. Mechanism, decomposition pathway and new evidences for self-healing of manganese oxides as efficient water oxidizing catalysts: new insights Mohammad Mahdi Najafpour, Mohsen Kompany-Zareh, Ali Zahraei, DavoodJafarian Sedigh, Hugues Jaccard, Maryam Khoshkam, R. David Britt, and William H. Casey Dalton Transactions 42, 14603–14611. Role of Oxido Incorporation and Ligand Lability in Expanding Redox Accessibility of Structurally Related Mn4 Clusters Jacob S. Kanady, Rosalie Tran, Jamie A. Stull, Luo Lu, Troy A. Stich, Michael W. Day, Junko Yano, R. David Britt, and Theodor Agapie Chemical Science 4, 3986–3996. Structural Insights into [Co4O4(C5H5N)4(CH3CO2)4]+, a Rare Co(IV)-Containing Cuboidal Complex Troy A. Stich, J. Krzystek, Brandon Q. Mercado, J. Gregory McAlpin, C. André Ohlin, Marilyn M. Olmstead, William H. Casey, R. David Britt Polyhedron 64, 304–307. Formation of MgO-Supported Manganese Carbonyl Complexes by Chemisorption of Mn(CO)5CH3 Supattra Khabuanchalad, Jatuporn Wittayakun, Rodrigo J. Lobo-Lapidus, Stefan Stoll, R. David Britt, and Bruce C Gates Langmuir 29, 6279–6286. Electron Paramagnetic Resonance Analysis of a Transient Species Formed During Water Oxidation Catalyzed by the Complex Ion [(bpy)2Ru(OH2)]2O4+ Jamie A. Stull, Troy A. Stich, James K. Hurst, and R. David Britt Inorg. Chem. 52, 4578–4586. Mechanism of assembly of the dimanganese- tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate Joseph A. Cotruvo, Jr., Troy A. Stich, R. David Britt, and JoAnne Stubbe J. Am. Chem. Soc. 135, 4027–4039. NRVS and EPR Spectroscopy of 57Fe-enriched [FeFe] Hydrogenase Indicate Stepwise Assembly of the H-cluster Jon M Kuchenreuther, Yisong Guo, Hongxin Wang, William K. Myers, Simon J George, Christine A Boyke, Yoshitaka Yoda, Esen Ercan Alp, Jiyong Zhao, R. David Britt, James R Swartz, and Stephen P. Cramer Biochemistry 52, 818–826.