Wooldridge, Karl - University of Nottingham

个人简介

I obtained my BSc (First Class) in Biological & Biochemical Sciences from the University of Salford (1987) and my PhD in Molecular Microbiology from the Department of Genetics, University of Leicester (1991). After postdoctoral work in Leicester I took up a post-doctoral fellowship in the Molecular Bacteriology & Immunology Group (MBIG), University of Nottingham. After moving to the BBSRC Institute of Food Research I returned to Nottingham in 2001 as a University Research Fellow within the MBIG and was appointed as a Lecturer in Bacteriology in 2003. My research interests include molecular pathogenesis, host cell interactions of bacterial pathogens and bacterial protein secretion. I have carried out extensive studies on the interactions of the enteric pathogen Campylobacter jejuni with model host cells in vitro and on iron-responsive gene regulation in this organism. My current research focuses on the molecular pathogenesis of, and host response to, Neisseria meningitidis and C. jejuni and the role of bacterial secreted proteins in pathogenesis and their potential as vaccine candidates.

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SHAMS F, OLDFIELD NJ, LAI SK, TUNIO SA, WOOLDRIDGE KG and TURNER DPJ, 2016. Fructose-1,6-bisphosphate aldolase of Neisseria meningitidis binds human plasminogen via its C-terminal lysine residue Microbiologyopen. 5, 340–350 KHAIRALLA AS, OMER SA, MAHDAVI J, ASLAM A, DUFAILU OA, SELF T, JONSSON A, GE?RG M, SJ?LINDER H, ROYER P, MARTINEZ-POMARES L, GHAEMMAGHAMI AM, WOOLDRIDGE KG, OLDFIELD NJ and ALA'ALDEEN DAA, 2015. Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. Cellular Microbiology. 17, 1008-1020 OKOLIE, CHARLES E., WOOLDRIDGE, KARL G., TURNER, DAVID P.J., COCKAYNE, ALAN and JAMES, RICHARD, 2015. Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes BMC Microbiology. 15, 157 OKOLIE CE, WOOLDRIDGE KG, TURNER DP, COCKAYNE A and JAMES R, 2015. Development of a new pentaplex real-time PCR assay for the identification of poly-microbial specimens containing Staphylococcus aureus and other staphylococci, with simultaneous detection of staphylococcal virulence and methicillin resistance markers. Molecular and cellular probes. 29(3), 144-50 MAHDAVI, JAFAR, PIRINCCIOGLU, NECMETTIN, OLDFIELD, NEIL J., CARLSOHN, ELISABET, STOOF, JEROEN, ASLAM, AKHMED, SELF, TIM, CAWTHRAW, SHAUN A., PETROVSKA, LILJANA, COLBORNE, NATALIE, SIHLBOM, CARINA, BORéN, THOMAS, WOOLDRIDGE, KARL G. and ALA'ALDEEN, DLAWER A. A., 2014. A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization: Open Biology Open Biology. 4(1), ALQAHTANI F, MAHDAVI J, WHELDON LM, VASSEY M, PIRINCCIOGLU N, ROYER P-J, QARANI SM, MORROLL S, STOOF J, HOLLIDAY ND, TEO SY, OLDFIELD NJ, WOOLDRIDGE KG and ALA'ALDEEN DAA, 2014. Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis. Open Biology. 4, 140053 SHAMS F, OLDFIELD NJ, WOOLDRIDGE KG and TURNER DPJ, 2014. Fructose-1,6-bisphosphate aldolase (FBA)-a conserved glycolytic enzyme with virulence functions in bacteria: 'ill met by moonlight'. Biochemical Society transactions. 42(6), 1792-5 ALQAHTANI F, MAHDAVI J, WHELDON LM, VASSEY M, PIRINCCIOGLU N, ROYER P, QARANI SM, MORROLL S, STOOF J, HOLLIDAY ND, TEO SY, OLDFIELD NJ, WOOLDRIDGE KG and ALA'ALDEEN DAA, 2014. Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis. Open biology. 4(10), ROYER, P-J, ROGERS, A. J., WOOLDRIDGE, K.G., TIGHE, P.J., MAHDAVI, J, RITTIG, M.G. and ALA'ALDEEN, D.A.A., 2013. Deciphering the contribution of human meningothelial cells to the inflammatory / antimicrobial response at the meninges. Infection and Immunity. 81(11), 4299-4310 BAYLISS, C.D., BIDMOS, F.A., ANJUM, A., MANCHEV, V.T., RICHARDS, R.L., GROSSIER, J., WOOLDRIDGE, K.G., KETLEY, J.M., BARROW, P.A., JONES, M.A. and TRETYAKOV, M.V., 2012. Phase Variable Genes Of Campylobacter Jejuni Exhibit High Mutation Rates And Specific Mutational Patterns But Mutability Is Not The Major Determinant Of Population Structure During Host Colonization. Nucleic Acids Research. 40(13), 82152 ABOUSEADA, N.M., ASSAFI, M.S.A., MAHDAVI, J., OLDFIELD, N.J., WHELDON, L.M., WOOLDRIDGE, K.G. and ALA’ALDEEN, D.A.A., 2012. Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2 PLoS ONE. 7(9), e46233 TAUSEEF, ISFHAN, HARRISON, ODILE B, WOOLDRIDGE, KARL G, FEAVERS, IAN M, NEAL, KEITH, GRAY, STEPHEN J, KRIZ, PAULA, TURNER, DAVID P J, ALA'ALDEEN, DLAWER, MAIDEN, MARTIN C J and BAYLISS, CHRISTOPHER DAVID, 2011. Influence of the Combination and Phase Variation Status of the Haemoglobin Receptors, HmbR and HpuAB, on Meningococcal Virulence. Microbiology (Reading, England). 157, 1446-1456 TUNIO, S.A., OLDFIELD, N.J., ALA'ALDEEN, D.A.A., WOOLDRIDGE, K.G. and TURNER, D.P.J., 2010. The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells BMC Microbiology. 10(November), 280 TUNIO, S.A., OLDFIELD, N.J., BERRY, A., ALA'ALDEEN, D.A.A., WOOLDRIDGE, K.G. and TURNER, D.P.J., 2010. The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion Molecular Microbiology. 76(3), 605-615 HARDIE, K.R, POMMIER, S and WILHELM, S., 2009. The secreted proteins of Pseudomonas aeruginosa: their export machineries and how they contribute to pathogenesis. In: KARL WOOLDRIDGE, ed., Bacterial Secreted Proteins Caister Academic Press. 451-479 ORIHUELA, C.J., MAHDAVI, J., THORNTON, J., MANN, B., WOOLDRIDGE, K.G., ABOUSEADA, N., OLDFIELD, N.J., SELF, T., ALA'ALDEEN, D.A.A. and TUOMANEN, E.I., 2009. Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. Journal of Clinical Investigation. 119(6), 1638-1646 OLDFIELD N.J. AND WOOLDRIDGE K.G., 2009. Protein secretion and the pathogenesis of Campylobacter jejuni. In: WOOLDRIDGE, K.G., ed., Bacterial secreted proteins Horizon Academic Press. 299-312 LI, Y., WOOLDRIDGE, K.G., JAVED, M.A., TANG, C.M. and ALA'ALDEEN, D.A.A., 2009. Secreted proteins of Neisseria meningitidis protect mice against infection Vaccine. 27(17), 2320-2325 WOOLDRIDGE, K. G. and VAN VLIET, A. H. M., 2009. In: KETLEY, JULIAN M. and KONKEL, MICHAEL E., eds., Iron Transport and Regulation Horizon Scientific Press. 293-310 OLDFIELD, N.J., WORRALL, K.E., RYCROFT, A.N., ALI, T., WOOLDRIDGE, K.G. and ALA'ALDEEN, D.A.A., 2009. AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge Vaccine. 27(38), 5278-5283 OLDFIELD, N.J., DONOVAN, E.A., WORRALL, K.E, WOOLDRIDGE, K.G., LANGFORD, P.R, RYCROFT, A.N and ALA'ALDEEN, D.A.A., 2008. Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae Vaccine. 26(16), 1942-1954 ALI, T., OLDFIELD, N.J., WOOLDRIDGE, K.G., TURNER, D.P. and ALA'ALDEEN, D.A.A., 2008. Functional characterization of AasP, a maturation protease autotransporter protein of Actinobacillus pleuropneumoniae Infection and Immunity. 76(12), 5608-5614 SPENCE, R.P., WRIGHT, V., ALA-ALDEEN, D.A.A., TURNER, D.P., WOOLDRIDGE, K.G. and JAMES, R., 2008. Validation of virulence and epidemiology DNA microarray for identification and characterization of Staphylococcus aureus isolates Journal of Clinical Microbiology. 46(5), 1620-1627 ASHGAR S.S., OLDFIELD N.J., WOOLDRIDGE K.G., JONES M.A., IRVING G.J., TURNER D.P. and ALA'ALDEEN D.A., 2007. CapA, an autotransporter protein of Campylobacter jejuni, mediates association to human epithelial cells and colonization of the chicken gut. Journal of Bacteriology. 189(5), 1856-1865 OLDFIELD, N.J., BLAND, S.J., TARAKTSOGLOU, M., DOS RAMOS, F.J., ROBINSON, K., WOOLDRIDGE, K.G. and ALA'ALDEEN, D.A.A., 2007. T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells. Cellular Microbiology. 9(2), 463-478