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个人简介

BSc University of Warwick (1983), PhD London/ICRF (1986), Research Associate Cambridge (1986-89), Lecturer (1986) Senior lecturer (2001) University of Nottingham.

研究领域

I am interested in the control of gene expression during the early stages of development in vertebrates, especially transcriptional regulation (both genetic and epigenetic) with respect to nervous system development. In addition I am interested in the role of genetic and epigenetic regulation in the formation of cancer, focussed on germ cell tumours and brain tumours . The Scotting lab is a young and internationally diverse group with graduate students coming from all corners of the globe. The current group includes 5 graduate students, 3 of whom are from overseas.

近期论文

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DZUL AZRI MOHAMED NOOR, JENNIE N JEYAPALAN, SAFIAH ALHAZMI, MATTHEW CARR, BENJAMIN SQUIBB, CLAIRE WALLACE, CHRISTOPHER TAN, MARTIN CUSACK, JAIME HUGHES, TOM READER, JANET SHIPLEY, DENISE SHEER and PAUL J SCOTTING, 2016. Genome-wide methylation analysis identifies genes silencedin non-seminoma cell lines npg Genomic Medicine. 1(1), 15009; TAN C and SCOTTING P, 2015. Expression of Kit and Etv1 in restricted brain regions supports a brain-cell progenitor as an origin for cranial germinomas. Cancer genetics. 208(3), 55-61 LIU Y, LAGHARI ZA, NOVOA CA, HUGHES J, WEBSTER JR, GOODWIN PE, WHEATLEY SP and SCOTTING PJ, 2014. Sox2 acts as a transcriptional repressor in neural stem cells. BMC neuroscience. 15(1), 95 TAN C and SCOTTING PJ, 2013. Stem cell research points the way to the cell of origin for intracranial germ cell tumours. An alternative cell of origin for intracranial germ cell tumours. The journal of pathology. 229(1), 4-11 CHENG-LIANG KUO, CHI MAN LAM, JANE E. HEWITT and PAUL J. SCOTTING, 2013. Formation of the Embryonic Organizer Is Restricted by the Competitive Influences of Fgf Signaling and the SoxB1 Transcription Factors PLOS ONE. 8(2), e57698 CHENG Y, HSIEH F, CHIANG M, SCOTTING PJ, SHIH H, LIN S, WU H and LEE H, 2013. Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. PloS one. 8(1), e54262 CHENG Y, SCOTTING PJ, HSU L, LIN S, SHIH H, HSIEH F, WU H, TSAO C and SHEN C, 2013. Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling. Cellular and molecular life sciences : CMLS. 70(5), 935-50 CUSACK, MARTIN and SCOTTING, PAUL, 2013. DNA methylation in germ cell tumour aetiology: current understanding and outstanding questions REPRODUCTION. 146(2), R49-R60 OSORNO, R., TSAKIRIDIS, A., WONG, F., CAMBRAY, N., ECONOMOU, C., WILKIE, R., BLIN, G., SCOTTING, P.J., CHAMBERS, I. and WILSON, V., 2012. The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression Development. 139(13), 2288-2298 LEE, SHIH-HAN, APPLEBY, VANESSA, JEYAPALAN, JENNIE N, PALMER, ROGER D, NICHOLSON, JAMES C, SOTTILE, VIRGINIE, GAO, ERNING, COLEMAN, NICHOLAS and SCOTTING, PAUL J, 2011. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. Journal of neuro-oncology. 101(3), 419-428 JEYAPALAN, J.N., NOOR, D.A.M., LEE, S.-H., TAN, C.L., APPLEBY, V.A., KILDAY, J.P., PALMER, R.D., SCHWALBE, E.C., CLIFFORD, S.C., WALKER, D.A., MURRAY, M.J., COLEMAN, N., NICHOLSON, J.C. and SCOTTING, P.J., 2011. Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance British Journal of Cancer. 105(4), 575-585 CHUNG P, LIN W, SCOTTING PJ, HSIEH F, WU H and CHENG Y, 2011. Zebrafish Her8a Is Activated By Su(H)-Dependent Notch Signaling And Is Essential For The Inhibition Of Neurogenesis. Plos One. 6(4), e19394 LEE, SH, APPLEBY, V, JEYAPALAN, JN, PALMER, RD, NICHOLSON, JC, SOTTILE, V, GAO, EN, COLEMAN, N and SCOTTING, PJ, 2011. Variable Methylation Of The Imprinted Gene, Snrpn, Supports A Relationship Between Intracranial Germ Cell Tumours And Neural Stem Cells Journal Of Neuro-Oncology. 101(3), 419-428 LEE, SHIH-HAN, JEYAPALAN, JENNIE N, APPLEBY, VANESSA, MOHAMED NOOR, DZUL AZRI, SOTTILE, VIRGINIE and SCOTTING, PAUL J, 2010. Dynamic methylation and expression of Oct4 in early neural stem cells. Journal of anatomy. 217(3), 203-13 ABELLó G, KHATRI S, RADOSEVIC M, SCOTTING PJ, GIRáLDEZ F, ALSINA B., 2010. Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placode Developmental Biology. 339(1), 166-78 SHIH, Y-H., KUO, C-L., HIRST, C.S., DEE, C.T., LIU, Y-R., LAGHARI, Z.A. and SCOTTING, P.J., 2010. SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling Development. 137(16), 2671-2681 TRIPATHI, VINEETA-BHASKER, ISHII, YASUO, ABU-ELMAGD, MUHAMMAD M and SCOTTING, PAUL J, 2009. The surface ectoderm of the chick embryo exhibits dynamic variation in its response to neurogenic signals. The International journal of developmental biology. 53(7), 1023-33 EL-ZAATARI, MOHAMAD, GRABOWSKA, ANNA M, MCKENZIE, ANDREW J, POWE, DESMOND G, SCOTTING, PAUL J and WATSON, SUSAN A, 2008. Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition. Regulatory Peptides. 146(1-3), 131-9 DEE, C.T., HIRST, C.S., SHIH, Y.-H., TRIPATHI, V.B., PATIENT, R.K. and SCOTTING, P.J., 2008. Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm Developmental biology. 320(1), 289-301 REX, M.: SCOTTING, P.J., 2008. In-Situ Hybridization to Sections (Nonradioactive). In: Molecular Embryology 461. Humana Press. 707-716 MATSUSHITA, SUSUMU, URASE, KOKO, KOMATSU, AKIRA, SCOTTING, PAUL J, KUROIWA, ATSUSHI and YASUGI, SADAO, 2008. Foregut endoderm is specified early in avian development through signal(s) emanating from Hensen's node or its derivatives. Mechanisms of development. 125(5-6), 377-95 SUN, S.-K., DEE, C.T., TRIPATHI, V.B., RENGIFO, A., HIRST, C.S. and SCOTTING, P.J., 2007. Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent. Developmental Biology. 303(2), 675-686 CLAPP, J., MITCHELL, L.M., BOLLAND, D.J., FANTES, J., CORCORAN, A.E., SCOTTING, P.J., ARMOUR, J.A.L. and HEWITT. J.E., 2007. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy American Journal of Human Genetics. 81(2), 264-279 DEE, C.T., GIBSON, A., RENGIFO, A., SUN, S.-K., PATIENT, R.K. and SCOTTING, P.J., 2007. A change in response to Bmp signalling precedes ectodermal fate choice International Journal of Developmental Biology. 51(1), 79-84 EL-ZAATARI,, TOBIAS,, GRABOWSKA,, KUMARI,, SCOTTING,, KAYE,, ATHERTON,, CLARKE,, POWE, and WATSON,, 2007. De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis. British Journal of Cancer. 96, 1855–1861

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