Loose, Matt - University of Nottingham - School of Life Sciences

个人简介

BA University of Cambridge (Jesus) 1997, DPhil King's College, University of London 2002, Lecturer, Institute of Genetics 2002 - Present.

研究领域

My lab is interested in the process of development and, ultimately, how cells are programmed to different phenotypes. We investigate these processes using a variety of approaches, including in vivo, in vitro and in silicomethods.

近期论文

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BROWN, L. E., MIDDLETON, A. M., KING, J. R. and LOOSE, M., 2016. Multicellular Mathematical Modelling of Mesendoderm Formation in Amphibians Bull. Math. Biol.. EVANS, T. and LOOSE, M., 2015. AlignWise: a tool for identifying protein-coding sequence and correcting frame-shifts BMC Bioinformatics. 16, 376 IP, C. L., LOOSE, M., TYSON, J. R., DE CESARE, M., BROWN, B. L., JAIN, M., LEGGETT, R. M., ECCLES, D. A., ZALUNIN, V., URBAN, J. M., PIAZZA, P., BOWDEN, R. J., PATEN, B., MWAIGWISYA, S., BATTY, E. M., SIMPSON, J. T., SNUTCH, T. P., BIRNEY, E., BUCK, D., GOODWIN, S., JANSEN, H. J., O'GRADY, J. and OLSEN, H. E., 2015. MinION Analysis and Reference Consortium: Phase 1 data release and analysis F1000Res. 4, 1075 BROWN WRA, THOMAS G, LEE NCO, BLYTHE M, LITI G, WARRINGER J and LOOSE MW, 2014. Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 111(5), 1903-8 BROWN LE, KING JR and LOOSE M, 2014. Two different network topologies yield bistability in models of mesoderm and anterior mesendoderm specification in amphibians. Journal of theoretical biology. 353C, 67-77 (In Press.) EVANS T, WADE CM, CHAPMAN FA, JOHNSON AD and LOOSE M, 2014. Acquisition of germ plasm accelerates vertebrate evolution. Science (New York, N.Y.). 344(6180), 200-3 CHATFIELD J, O'REILLY M, BACHVAROVA RF, FERJENTSIK Z, REDWOOD C, WALMSLEY M, PATIENT R, LOOSE M and JOHNSON AD, 2014. Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos. Development (Cambridge, England). 141(12), 2429-40 WHELDON LM, ABAKIR A, FERJENTSIK Z, DUDNAKOVA T, STROHBUECKER S, CHRISTIE D, DAI N, GUAN S, FOSTER JM, CORRêA IR, LOOSE M, DIXON JE, SOTTILE V, JOHNSON AD and RUZOV A, 2014. Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cells. Cell reports. 7(5), 1353-61 CHEN, WEI-CHUNG, PAULS, STEFAN, BACHA, JAMIL, ELGAR, GREG, LOOSE, MATTHEW and SHIMELD, SEBASTIAN M., 2014. Dissection of a Ciona regulatory element reveals complexity of cross-species enhancer activity DEVELOPMENTAL BIOLOGY. 390(2), 261-272 P. BOKES, J. R. KING, A. T. A. WOOD and M. LOOSE, 2013. Transcriptional bursting diversifies the behaviour of a toggle switch: hybrid simulation of stochastic gene expression Bulletin of Mathematical Biology. 75, 351-371 LOOSE M, PATIENT R, FANG X and LEI H, 2013. Gene regulatory networks in the genomics era. Genomics, proteomics & bioinformatics. 11(3), 133-4 MIDDLETON AM, KING JR and LOOSE M, 2013. Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty-Nodal signalling. Journal of mathematical biology. 67(6-7), 1393-424 BOKES, P., KING, J.R., WOOD, A.T.A. and LOOSE, M., 2012. Exact and approximate distributions of protein and mRNA levels in the low-copy regime of gene expression Journal of Mathematical Biology. 64(5), 829-854 ALMEIDA, R.D., LOOSE, M., SOTTILE, V., MATSA, E., DENNING, C., YOUNG, L., JOHNSON, A.D., GERING, M. and RUZOV, A., 2012. 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development Epigenetics. 7(4), 383-389 ALMEIDA, R.D., SOTTILE, V., LOOSE, M., DE SOUSA, P.A., JOHNSON, A.D. and RUZOV, A., 2012. Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals Epigenetics. 7(2), 137-140 BOKES, PAVOL, KING, JOHN R., WOOD, ANDREW T. A. and LOOSE, MATTHEW, 2012. Multiscale stochastic modelling of gene expression JOURNAL OF MATHEMATICAL BIOLOGY. 65(3), 493-520 D. DE POMERAI1, C. ANBALAGAN1, I. LAFAYETTE1, D. RAJAGOPALAN1, M. LOOSE1, M. HAQUE2 & J. KING2, 2010. High-throughput analysis of multiple stress pathways using GFP reporters in C. elegans.. In: Environmental Toxicology III Wessex Institute for Technology Press. (In Press.) SWIERS, G., CHEN, Y-H., JOHNSON, A.D. and LOOSE, M., 2010. A conserved mechanism for vertebrate mesoderm specification in urodele amphibians and mammals Developmental Biology. 343(1-2), 138-152 COOPER, M.B, LOOSE, M and BROOKFIELD, J.F.Y., 2009. The evolutionary influence of binding site organization on gene regulatory networks. Biosystems. 96, 185-93 MIDDLETON, A.M., KING, J.R. and LOOSE, M., 2009. Bistability in a model of mesoderm and anterior mesendoderm specification in Xenopus laevis. Journal of Theoretical Biology. 260(1), 41-55 BACHA, J., BRODIE, J.S. and LOOSE, M.W., 2009. myGRN: a database and visualisation system for the storage and analysis of developmental genetic regulatory networks BMC Developmental Biology. 9, 33 DE POMERAI, D, MADHAMSHETTIWAR, P, ANBALAGAN, C, LOOSE, M, HAQUE, M, KING, J, CHOWDHURI, D.K, SINHA, P, JOHNSEN, B and BAILLIE, D., 2008. The stress-response network in animals: proposals to develop a predictive mathematical model. Open Toxicology Journal. 2, 71-76 BOKES, P, KING, J and LOOSE, M., 2008. A bistable genetic switch which does not require high cooperativity at the promoter: a two-timescale model for the PU.1 - GATA-1 interaction Mathematical Medicine & Biology. (In Press.) COOPER, M., LOOSE, M. and BROOKFIELD, J.F.Y., 2007. Evolutionary modelling of feed forward loops in gene regulatory networks. Biosystems Elsevier. Available at: SONEJI S, HUANG S, LOOSE M, DONALDSON IJ, PATIENT R, GOTTGENS B, ENVER T, MAY G., 2007. Inference, validation and dynamic modelling of transcription networks in multipotent hematopoietic cells. Ann N Y Acad Sci. (In Press.)