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SCOTT D, GARNER TP, LONG J, STRACHAN J, MISTRY SC, BOTTRILL AR, TOOTH DJ, SEARLE MS, OLDHAM NJ and LAYFIELD R, 2016. Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin. Proteomics. 16(14), 1961-9
ZEROVNIK E, JERALA NK and LAYFIELD R, 2016. Recent developments in treating Alzheimer’s disease. J Alzheimers Dis Parkinsonism. 5, 220
GOODE A, BUTLER K, LONG J, CAVEY J, SCOTT D, SHAW B, SOLLENBERGER J, GELL C, JOHANSEN T, OLDHAM NJ, SEARLE MS and LAYFIELD R, 2016. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy. 12(7), 1094-104
SCOTT D, STRACHAN J, KRISHNA VG, SHAW B, TOOTH DJ, SEARLE MS, OLDHAM NJ and LAYFIELD R, 2016. Method for the Purification of Endogenous Unanchored Polyubiquitin Chains. Methods in Molecular Biology. 1449, 203-13
GOODE A, REA S, SULTANA M, SHAW B, SEARLE MS and LAYFIELD R, 2016. ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling. Molecular and Cellular Neurosciences. 76, 52-58
MANZI L, BARROW AS, SCOTT D, LAYFIELD R, WRIGHT TG, MOSES JE and OLDHAM NJ, 2016. Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions. Nature communications. 7, 13288
HAFEEZ G, GALAZIS N, DOCHEVA N, LAYFIELD R and ATIOMO W, 2015. Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. Human Reproduction. 30(1), 133-48
MAJCHER V, GOODE A, JAMES V and LAYFIELD R, 2015. Autophagy receptor defects and ALS-FTLD. Molecular and Cellular Neuroscience. 66, 43-52
SCOTT D, LAYFIELD R and OLDHAM NJ, 2015. Structural Insights into Interactions between Ubiquitin Specific Protease 5 and its Polyubiquitin substrates by Mass Spectrometry and Ion Mobility Spectrometry. Protein Science. 24(8), 1257-63
SCOTT, DANIEL, LAYFIELD, ROBERT and OLDHAM, NEIL J., 2015. Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5. PROTEOMICS. 15(16), 2835-2841
SCOTT, DANIEL, OLDHAM, NEIL J., STRACHAN, JO, SEARLE, MARK S. and LAYFIELD, ROBERT, 2015. Ubiquitin-binding domains: Mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes PROTEOMICS. 15(5-6), 844-861
SHAPIRO IM, LAYFIELD R*, LOTZ M*, SETTEMBRE C* and WHITEHOUSE C*, 2014. Boning up on autophagy: the role of autophagy in skeletal biology. Autophagy. 10(1), 7-19
HAOULA Z, SHAW B, DAYKIN C, HODGMAN C, LAYFIELD R and ATIOMO W, 2014. Validation of proteomic biomarkers previously found to be differentially expressed in women with Polycystic Ovary Syndrome: A cross sectional study. Gynecological Endocrinology. 30(3), 213-216
REA S, MAJCHER V, SEARLE MS and LAYFIELD R, 2014. SQSTM1 mutations - bridging Paget disease of bone and ALS/FTLD. Experimental Cell Research. 325, 27-37
GOODE A, LONG JE, SHAW B, RALSTON SH, VISCONTI MR, GIANFRANCESCO F, ESPOSITO T, GENNARI L, MERLOTTI D, RENDINA D, REA SL, SULTANA M, SEARLE MS and LAYFIELD R, 2014. Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function. BBA - Molecular Basis of Disease. 1842, 992-1000
WRIGHT T, REA S, GOODE A, BENNETT AJ, RATAJCZAK T, LONG JE, SEARLE MS, GOLDRING CE, PARK BK, COPPLE IM and LAYFIELD R, 2013. The S349T mutation of SQSTM1 links Keap1/Nrf2 signaling to Paget's disease of bone. Bone. 52, 699-706
SOKRATOUS K, LAYFIELD R and OLDHAM NJ, 2013. The effects of cation adduction upon the conformation of three-helix bundle protein domains. International Journal for Ion Mobility Spectrometry. 16, 19-27
REA SL, WALSH JP, LAYFIELD R, RATAJCZAK T and XU J, 2013. New insights into the role of Sequestosome 1/p62 mutant proteins in the pathogenesis of Paget’s disease of bone. Endocrine Reviews. 34, 501-524
GALAZIS N, PANG Y, GALAZI M, HAOULA Z, LAYFIELD R and ATIOMO W, 2013. Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. Gynecological Endocrinology. 29(7), 638-44
TOOTH, D., GARSED, K., SINGH, G., MARCIANI, L., LAM, C., FORDHAM, I., FIELDS, A., BANWAIT, R., LINGAYA, M., LAYFIELD, R., HASTINGS, M., WHORWELL, P. and SPILLER, R., 2013. Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea:origin and effect of gut transit Gut. n/a(n/a), n/a
STRACHAN J, SHAW B, GOPALA KRISHNA V, SCOTT D, DEL POZO JC, HILL K, GAUTAM M, SKOWYRA D, JACOBSON AD, LIU CW, OLDHAM N and LAYFIELD R, 2013. Broad utility of an affinity-enrichment strategy for unanchored polyubiquitin chains Journal of Proteomics & Bioinformatics. S7, 1-7
GIANFRANCESCO F, RENDINA D, DI STEFANO M, MINGIONE A, ESPOSITO T, MERLOTTI D, GALLONE S, MAGLIOCCA S, GOODE A, FORMICOLA D, MORELLO G, LAYFIELD R, FRATTINI A, DE FILIPPO G, NUTI R, SEARLE M, STRAZZULLO P, ISAIA G, MOSSETTI G and GENNARI L, 2012. A non-synonymous TNFRSFIIA variation increases NF-kB activity and the severity of Paget's disease. Journal of Bone and Mineral Research. 27, 443-452
CHADWICK L, GENTLE L, STRACHAN J and LAYFIELD R, 2012. Unchained maladie - A reassessment of the role of Ubb(+1)-capped polyubiquitin chains in Alzheimer's disease. Neuropathology and Applied Neurobiology. 38, 118-131
STRACHAN, J., ROACH, L., SOKRATOUS, K., TOOTH, D., LONG, J., GARNER, T.P., SEARLE, M.S., OLDHAM, N.J. and LAYFIELD, R., 2012. Insights into the molecular composition of endogenous unanchored polyubiquitin chains Journal of Proteome Research. 11(3), 1969-1980
SEARLE MS, GARNER TP, STRACHAN J, LONG J, ADLINGTON J, CAVEY JR, SHAW B and LAYFIELD R, 2012. Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains. Biochem Soc Transactions. 40(2), 404-408
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