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研究领域

My research interests are the mechanisms and structures of proteins involved in transmembrane flux.

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MITTRA R, PAVY M, SUBRAMANIAN N, GEORGE AM, O'MARA ML, KERR ID and CALLAGHAN R, 2017. Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein. Biochemical pharmacology. 123, 19-28 WONG, KELVIN, BRIDDON, STEPHEN J., HOLLIDAY, NICHOLAS D. and KERR, IAN D., 2016. Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1863(1), 19-29 AL-GHAFARI, A. B., PUNJARUK, W., STORER, L. C. D., CARRIER, D. J., HUSSEIN, D., COYLE, B. and KERR, I. D., 2016. Long-term exposure to irinotecan reduces cell migration in glioma cells JOURNAL OF NEURO-ONCOLOGY. 127(3), 455-462 HORSEY AJ, COX MH, SARWAT S and KERR ID, 2016. The multidrug transporter ABCG2: still more questions than answers. Biochemical Society transactions. 44(3), 824-30 THEODOULOU, FREDERICA L. and KERR, IAN D., 2015. ABC transporter research: going strong 40 years on BIOCHEMICAL SOCIETY TRANSACTIONS. 43, 1033-1040 COYLE, BETH, KESSLER, MAYA, SABNIS, DURGAGAURI H. and KERR, IAN D., 2015. ABCB1 in children's brain tumours BIOCHEMICAL SOCIETY TRANSACTIONS. 43, 1018-1022 DARBY, RICHARD A. J., UNSWORTH, AMANDA, KNAPP, STEFAN, KERR, IAN D. and CALLAGHAN, RICHARD, 2015. Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors CANCER CHEMOTHERAPY AND PHARMACOLOGY. 76(4), 853-864 WONG K, BRIDDON SJ, HOLLIDAY ND and KERR ID, 2015. Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques. Biochimica et biophysica acta. 1863(1), 19-29 HAIDER AJ, COX MH, JONES N, GOODE AJ, BRIDGE KS, WONG K, BRIGGS D and KERR ID, 2015. Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences. Bioscience reports. 35(4), POLLOCK NL, MCDEVITT CA, COLLINS R, NIESTEN PHM, PRINCE S, KERR ID, FORD RC and CALLAGHAN R, 2014. Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids. Biochimica et biophysica acta. 1838(1 Pt B), 134-47 WONG K, MA J, ROTHNIE A, BIGGIN PC and KERR ID, 2014. Towards understanding promiscuity in multidrug efflux pumps. Trends in biochemical sciences. 39(1), 8-16 VAN WONDEREN JH, MCMAHON RM, O'MARA ML, MCDEVITT CA, THOMSON AJ, KERR ID, MACMILLAN F and CALLAGHAN R, 2014. The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. The FEBS journal. 281(9), 2190-201 GULATI S, JAMSHAD M, KNOWLES TJ, MORRISON KA, DOWNING R, CANT N, COLLINS R, KOENDERINK JB, FORD RC, OVERDUIN M, KERR ID, DAFFORN TR and ROTHNIE AJ, 2014. Detergent-free purification of ABC (ATP-binding-cassette) transporters. The Biochemical journal. 461(2), 269-78 OTHMAN RT, KIMISHI I, BRADSHAW TD, STORER LCD, KORSHUNOV A, PFISTER SM, GRUNDY RG, KERR ID and COYLE B, 2014. Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta neuropathologica communications. 2, 57 DE MARCOS LOUSA C, VAN ROERMUND CWT, POSTIS VLG, DIETRICH D, KERR ID, WANDERS RJA, BALDWIN SA, BAKER A and THEODOULOU FL, 2013. Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 110(4), 1279-84 KAY, C., WOODWARD, K.D., LAWLER, K., SELF, T.J., DYALL, S.D. and KERR, I.D., 2012. The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis PLoS Neglected Tropical Diseases. 6(6), e1693 KAY, C., LAWLER, K., SELF, T. J., DYALL, S. D. and KERR, I. D., 2012. Localisation of a family of complex-forming beta-barrels in the T. vaginalis hydrogenosomal membrane: FEBS Lett FEBS Lett. 586(22), 4038-45 DORRIAN JM, BRIGGS DA, RIDLEY ML, LAYFIELD R, KERR ID, 2011. Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics. FEBS Journal. 278(21), 4015-24 DE SMET, IVE, VOSS, UTE, LAU, STEFFEN, WILSON, MICHAEL, SHAO, NING, TIMME, RUTH, SWARUP, RANJAN, KERR, IAN, HODGMAN, CHARLIE, BOCK, RALPH, BENNETT, MALCOLM, JüRGENS, GERD and BEECKMAN, TOM, 2011. Unraveling the evolution of auxin signaling. Plant Physiology. 155, 209-221 HAIDER, A.J., BRIGGS, D., SELF, T.J., CHILVERS, H.L., HOLLIDAY, N.D. and KERR, I.D., 2011. Dimerization of ABCG2 analysed by bimolecular fluorescence complementation PLoS ONE. 6(10), e25818 KERR ID, HAIDER AJ and GELISSEN IC, 2011. The Abcg Family Of Membrane-Associated Transporters: You Don't Have To Be Big To Be Mighty. British Journal Of Pharmacology. 164(7), 1767-79 HUSSEIN, D., PUNJARUK, W., STORER, L.C.D., SHAW, L., OTHMAN, R.T., PEET, A., MILLER, S., BANDOPADHYAY, G., HEATH, R., KUMARI, R., BOWMAN, K.J., BRAKER, P., RAHMAN, R., JONES, G.D.D. and WATSON, S., 2010. Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion Neuro-oncology. 13(1), 70-83 CROWLEY, EMILY, O'MARA, MEGAN L, KERR, IAN D and CALLAGHAN, RICHARD, 2010. Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1. The FEBS journal. 277(19), 3974-85 KERR, IAN D, JONES, PETER M and GEORGE, ANTHONY M, 2010. Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues. The FEBS journal. 277(3), 550-63 CHUTHAPISITH, S, BEAN, B, COWLEY, G, EREMIN, JM, SAMPHAO, S, LAYFIELD, R, KERR, ID, WISEMAN, J, EL-SHEEMY, M, SREENIVASAN, T, EREMIN, O, 2009. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. European Journal of Cancer. 45(7), 1274-81

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