Holliday, Nick - University of Nottingham

个人简介

Following undergraduate studies at the University of Cambridge (BA St John's College, 1994), Nick Holliday obtained his PhD from King's College London (1998), supported by an AJ Clark PhD studentship from the British Pharmacological Society. During subsequent postdoctoral work in London, his interests in peptide messengers regulating appetite and metabolism became focused on molecular mechanisms underlying the signalling and regulation of their receptors. Nick was awarded a independent RCUK fellowship at the University of Nottingham in 2006, followed by Lecturer (2011) and Associate Professor (2013) positions. While at Nottingham, Nick's group has been funded by the MRC, charity and industrial collaborations, and in 2011 he was awarded the Bill Bowman travelling lectureship from the British Pharmacological Society. He has also been actively involved in public engagement, including an arts crossover project to explain the use of imaging in pharmacology ("Hijacking Natural Systems"), funded by the Wellcome Trust.

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WONG, KELVIN, BRIDDON, STEPHEN J., HOLLIDAY, NICHOLAS D. and KERR, IAN D., 2016. Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1863(1), 19-29 STOTT, LISA A., HALL, DAVID A. and HOLLIDAY, NICHOLAS D., 2016. Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data BIOCHEMICAL PHARMACOLOGY. 101, 1-12 LIU M, MOUNTFORD SJ, RICHARDSON RR, GROENEN M, , HOLLIDAY ND and THOMPSON PE, 2016. Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach. J Med Chem. 59(13), 6059-6069 2016. Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y1R and Y4R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15. Bioconjugate chemistry. (In Press.) NORTHFIELD, SUSAN E., MOUNTFORD, SIMON J., WIELENS, JEROME, LIU, MENGJIE, ZHANG, LEI, HERZOG, HERBERT, HOLLIDAY, NICHOLAS D., SCANLON, MARTIN J., PARKER, MICHAEL W., CHALMERS, DAVID K. and THOMPSON, PHILIP E., 2015. Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides AUSTRALIAN JOURNAL OF CHEMISTRY. 68(9), 1365-1372 WONG K, BRIDDON SJ, HOLLIDAY ND and KERR ID, 2015. Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques. Biochimica et biophysica acta. 1863(1), 19-29 KILPATRICK LE, HUMPHRYS LJ and HOLLIDAY ND, 2015. A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers. Molecular pharmacology. 87(4), 718-32 VALENTIN-HANSEN L, FRIMURER TM, MOKROSINSKI J, HOLLIDAY ND and SCHWARTZ TW, 2015. Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network. The Journal of biological chemistry. 290(40), 24495-508 STOTT LA, HALL DA and HOLLIDAY ND, 2015. Unravelling intrinsic efficacy and ligand bias at G protein coupled receptors: A practical guide to assessing functional data. Biochemical pharmacology. 101, 1-12 ALQAHTANI F, MAHDAVI J, WHELDON LM, VASSEY M, PIRINCCIOGLU N, ROYER P, QARANI SM, MORROLL S, STOOF J, HOLLIDAY ND, TEO SY, OLDFIELD NJ, WOOLDRIDGE KG and ALA'ALDEEN DAA, 2014. Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis. Open biology. 4(10), MOUNTFORD SJ, LIU M, ZHANG L, GROENEN M, HERZOG H, HOLLIDAY ND and THOMPSON PE, 2014. Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging. Organic & biomolecular chemistry. 12(20), 3271-81 ENGELSTOFT MS, NORN C, HAUGE M, HOLLIDAY ND, ELSTER L, LEHMANN J, JONES RM, FRIMURER TM and SCHWARTZ TW, 2014. Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119. British journal of pharmacology. 171(24), 5774-89 SIVERTSEN, B., HOLLIDAY, N., MADSEN, A. N. and HOLST, B., 2013. Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor BRITISH JOURNAL OF PHARMACOLOGY. 170(7), 1349-1362 HOLLIDAY ND, WATSON SJ and BROWN AJH, 2012. Drug discovery opportunities and challenges at G protein coupled receptors for long chain free fatty acids Frontiers in Endocrinology: Frontiers in Molecular and Structural Endocrinology. 2, WATSON, S-J., BROWN, A.J.H. and HOLLIDAY, N.D., 2012. Differential signaling by splice variants of the human free fatty acid receptor, GPR120 Molecular Pharmacology. 81(5), 631-642 KILPATRICK, L.E., BRIDDON, S.J. and HOLLIDAY, N.D., 2012. Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveal the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors Biochemica Biophysica Acta: Molecular Cell Research. 1823(6), 1068-1081 HANSEN, L.V., GROENEN, M., NYGAARD, R., FRIMURER, T.M., HOLLIDAY, N.D. and SCHWARTZ, T.W., 2012. The arginine of the DRY motif in TM-III functions as a balancing microswitch in the activation of the beta2-adrenoceptor Journal of Biological Chemistry. 287, 31973-31982 KILPATRICK LE and HOLLIDAY ND, 2012. Dissecting the pharmacology of g protein-coupled receptor signaling complexes using bimolecular fluorescence complementation. Methods in molecular biology (clifton, n.j.). 897, 109-38 HAIDER, A.J., BRIGGS, D., SELF, T.J., CHILVERS, H.L., HOLLIDAY, N.D. and KERR, I.D., 2011. Dimerization of ABCG2 analysed by bimolecular fluorescence complementation PLoS ONE. 6(10), e25818 EVANS, E.L., SAXTON, J., SHELTON, S.J., BEGITT, A., HOLLIDAY, N.D., HIPSKIND, R.A. and SHAW, P.E., 2011. Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1 Nucleic Acids Research. 39(15), 6390-6402 SIVERTSEN, B, LANG, MJ, FRIMURER, TM, HOLLIDAY, ND, BACH, A, ELS, S, ENGELSTOFT, MS, PETERSEN, PS, MADSEN, AN, SCHWARTZ, TW, BECK-SICKINGER, AG and HOLST, B, 2011. Unique Interaction Pattern For A Functionally Biased Ghrelin Receptor Agonist Journal Of Biological Chemistry. 286(23), 20845-20860 KILPATRICK, L.E., BRIDDON, S.J., HILL, S.J. and HOLLIDAY, N.D., 2010. Quantitative analysis of neuropeptide Y receptor association with β-arrestin2 measured by bimolecular fluorescence complementation British Journal of Pharmacology. 160(4), 892-906 ROSE, RH, BRIDDON, SJ and HOLLIDAY, ND, 2010. Bimolecular Fluorescence Complementation:Lighting Up Seven Transmembrane Domain Receptor Signalling Networks British Journal of Pharmacology. 738-750 JORGENSEN, R., HOLLIDAY, N.D., HANSEN, J.L., VRECL, M., HEDING, A., SCHWARTZ, T.W. and ELLING, C.E., 2008. Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer Molecular Pharmacology. 73(2), 349-358 HOLLIDAY, N.D., TOUGH, I.R. and COX, H.M., 2007. A functional comparison of recombinant and native sst2 receptor variants in epithelia British Journal of Pharmacology. 152(1), 132-140