Farr , Tracy D - University of Nottingham

研究领域

I am interested in the pathophysiology of cerebrovascular disease, in particular ischemic stroke and vascular dementia. I want to understanding how microstructural changes in the blood vessels and brain cause cognitive decline. I am interested in identifying neuroimaging biomarkers for cerebrovascular disease. Within this context, I use structural and functional neuroimaging techniques to identify pre-symptomatic changes in the diseased brain. I have an active interest in translation and testing various therapeutic strategies in an experimental setting.

近期论文

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DEMUTH HU, DIJKHUIZEN RM, FARR TD, GELDERBLOM M, HORSBURGH K, IADECOLA C, MCLEOD DD, MICHALSKI D, MURPHY TH, ORBE J, OTTE WM, PETZOLD GC, PLESNILA N, REISER G, REYMANN KG, RUEGER MA, SAUR D, SAVITZ SI, SCHILLING S, SPRATT NJ, TURNER RJ, VEMUGANTI R, VIVIEN D, YEPES M, ZILLE M, BOLTZE J and , 2017. Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative neurology and neuroscience. (In Press.) BOEHM-STURM P, FüCHTEMEIER M, FODDIS M, MUELLER S, TRUEMAN RC, ZILLE M, RINNENTHAL JL, KYPRAIOS T, SHAW L, DIRNAGL U and FARR TD, 2017. Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment. Stroke. (In Press.) ARIZA DE SCHELLENBERGER A, KRATZ H, FARR TD, L?WA N, HAUPTMANN R, WAGNER S, TAUPITZ M, SCHNORR J and SCHELLENBERGER EA, 2016. Labeling of mesenchymal stem cells for MRI with single-cell sensitivity. Int J Nanomedicine. 11, 1517-35 TRUEMAN RC, DIAZ C, FARR TD, HARRISON DJ, FULLER A, TOKARCZUK PF, STEWART A, STEWART A, STEWART A, PAISEY SJ and DUNNETT SB, 2016. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism. 1-13 DONATH, S, AN, J, LIN LIN LEE, S, GERTZ, K, DATWYLER, AL, HARMS, U, MUELLER, S, FARR, TD, FUECHTEMEIER, M, LAETTIG-TUENNEMANN, G, LIPS, J, FODDIS, M, MOSCH, L, BERNARD, R, GRITTNER, U, BALKAYA, M, KRONENBERG, G, DIRNAGL, U, ENDRES, M and HARMS, C, 2016. Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. The Journal of Neuroscience. 36(31), 8132-8148 AHMED J, DWYER DM, FARR TD, HARRISON DJ, DUNNETT SB and TRUEMAN RC, 2016. Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X16684141 (In Press.) FüCHTEMEIER M, BRINCKMANN MP, FODDIS M, KUNZ A, PO C, CURATO C, DIRNAGL U and FARR TD, 2015. Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment JCBFM. 35(3), 476-484 JADAVJI NM, FARR TD, LIPS J, KHALIL AA, BOEHM-STURM P, FODDIS M, HARMS C, FüCHTEMEIER M and DIRNAGL U, 2015. Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural brain research. 283, 215-26 LóPEZ-GIL X, AMAT-ROLDAN I, TUDELA R, CASTA?é A, PRATS-GALINO A, PLANAS AM, FARR TD and SORIA G, 2014. DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneously hypertensive rats undergoing executive function tests Front Aging Neurosci. 6(167), 1-13 VANDEPUTTE C, REUMERS V, AELVOET SA, THIRY I, DE SWAEF S, VAN DEN HAUTE C, PASCUAL-BRAZO J, FARR TD, VANDE VELDE G, HOEHN M, HIMMELREICH U, VAN LAERE K, DEBYSER Z, GIJSBERS R and BAEKELANDT V, 2014. Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiology of disease. 69, 144-55 FARR TD, LAI CH, GRüNSTEIN D, ORTS-GIL G, WANG CC, BOEHM-STURM P, SEEBERGER PH and HARMS C, 2014. Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano letters. 14(4), 2130-4 HARMS C, DATWYLER AL, WIEKHORST F, TRAHMS L, LINDQUIST R, SCHELLENBERGER E, MUELLER S, SCHüTZ G, ROOHI F, IDE A, FüCHTEMEIER M, GERTZ K, KRONENBERG G, HARMS U, ENDRES M, DIRNAGL U and FARR TD, 2013. Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke JCBFM. 33(5), E1-E9 BOEHM-STURM P, FARR TD, ADAMCZAK JA, JIKELI J, MENGLER L, WIEDERMANN D, KALLUR T, KISELEV V and HOEHN M, 2013. Vascular changes after stroke in the rat: a longitudinal study using optimized magnetic resonance imaging Cont Med Mol Imag. 8(5), 383-392 ZILLE M, FARR TD, PRZESDZING I, MüLLER J, SOMMER C, DIRNAGL U and WUNDER A, 2012. Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives JCBFM. 32(2), 213-31 TRUEMAN RC, HARRISON DJ, DWYER DM, DUNNETT SB, HOEHN M and FARR TD, 2011. A critical re-examination of the intraluminal filament MCAO model: impact of external carotid artery transection Transl Stroke Res. 2(4), 651-61 PATKAR S, FARR TD, COOPER E, DOWELL FJ and CARSWELL HV, 2011. Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain. Eur J Neurosci. 34(3), 382-93 BAHMANI P, SCHELLENBERGER E, KLOHS J, STEINBRINK J, CORDELL R, ZILLE M, MULLER J, HARHAUSEN D, HOFSTRA L, REUTELINGSPERGER C, FARR TD, DIRNAGL U and WUNDER A, 2011. Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining JCBFM. 31(5), 1311-20 FARR TD, SEEHAFER JU, NELLES M and HOEHN M, 2011. Challenges towards MR-imaging of the peripheral inflammatory response in the subacute and chronic stages of transient focal ischemia NMR in Biomed. 24(1), 35- 45 FARR TD and TRUEMAN RC, 2011. Chapter 6. Functional assessment of subcortical ischemia.. In: Animal models of movement disorders. 2. Springer/Humana Publishing. 91-114 KALLUR T, FARR TD, B?HM-STURM P, KOKAIA Z and HOEHN M, 2011. Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain Eur J Neurosci. 34(3), 382-393 FARR TD and WEGENER S, 2010. The use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence JCBFM. 30(4), 703-717 SEEHAFER JU, KALTHOFF D, FARR TD, WIEDERMANN D and HOEHN M, 2010. No increase of the blood oxygenation level-dependent functional magnetic resonance imaging signal with higher field strength: implications for brain activation studies J Neurosci. 30(15), 704-712 ADAMCZAK JM, FARR TD, SEEHAFER JU, KALTHOFF D and HOEHN M, 2010. High field BOLD response to forepaw stimulation in the mouse Neuroimage. 51(2), 704-712 CARSWELL HVO, MACRAE IM and FARR TD, 2009. Complexities of oestrogen in stroke Clin Sci. 118(6), 375-389 FARR TD, CARSWELL HV, MCCANN DJ, SATO M, BRYANT HU, DODGE JA and MACRAE IM, 2008. The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia J Neuroendocrin. 20(3), 366-374