Donaldson, Lucy - University of Nottingham

个人简介

Lucy is a neurophysiologist with expertise in neuronal function in acute and chronic pain, particularly in arthritis. Lucy studied for her undergraduate (Dentistry BDS, Neuroscience BSc (Hons) and postgraduate (PhD, Pharmacology) degrees at the University of Edinburgh. From there she moved to a post-doctoral position at the University of California, working on several projects including tachykinin receptor expression and function (with Michael Hanley), neuronal cation-chloride co-transporters (with John Payne) and protein kinases (with Don Walsh). In 1996 she was appointed to a Lectureship at the University of Leicester, where she worked on neuronal prostaglandins in collaboration with Blair Grubb. In 1999 she moved to the Dept of Physiology, University of Bristol. She has worked on multiple projects since then including TRP channel, cyclooxygenase and galanin contributions to primary afferent nociceptor function (MRC, Arthritis Research UK funded), neuronal mechanisms in arthritic symmetry (Wellcome Trust funded), descending prostanergic facilitatory control systems (BBSRC, MRC funded, with Prof Bridget Lumb), mTOR peripheral translation mechanisms (MRC funded, with Profs Lumb and Hunt), and most recently vascular endothelial growth factors in neuroprotection and pain (funded by Diabetes UK and Arthritis Research UK). Over the last 10 years, she has also developed a research program in human taste perception in health and disease, in collaboration with Jan Melichar, David Nutt, and Jon Potokar from the University of Bristol. In September 2013, Lucy moved to an Associate Professor position in Life Sciences at the University of Nottingham.

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DONALDSON LF and BEAZLEY-LONG N, 2016. Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug discovery today. 2016. The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain. Neurobiology of disease. (In Press.) DRAKE RA, LEITH JL, ALMAHASNEH F, MARTINDALE J, WILSON AW, LUMB B and DONALDSON LF, 2016. Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary Hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(35), 9026-40 BATES DO, MORRIS JC, OLTEAN S and DONALDSON LF, 2016. Pharmacology of Modulators of Alternative Splicing. Pharmacological reviews. 69(1), 63-79 HULSE RP, BEAZLEY-LONG N, VED N, BESTALL SM, RIAZ H, SINGHAL P, BALLMER HOFER K, HARPER SJ, BATES DO and DONALDSON LF, 2015. Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration. Clinical science (London, England : 1979). 129(8), 741-56 DUNHAM JP, HULSE RP and DONALDSON LF, 2015. A novel method for delivering ramped cooling reveals rat behaviours at innocuous and noxious temperatures: A comparative study of human psychophysics and rat behaviour. Journal of neuroscience methods. 249, 29-40 OLTEAN S, QIU Y, FERGUSON JK, STEVENS M, NEAL C, RUSSELL A, KAURA A, ARKILL KP, HARRIS K, SYMONDS C, LACEY K, WIJEYARATNE L, GAMMONS M, WYLIE E, HULSE RP, ALSOP C, COPE G, DAMODARAN G, BETTERIDGE KB, RAMNATH R, SATCHELL SC, FOSTER RR, BALLMER-HOFER K, DONALDSON LF, BARRATT J, BAELDE HJ, HARPER SJ, BATES DO and SALMON AHJ, 2015. Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. 26(8), 1889-1904 HSIEH, MENGTZU, DONALDSON, LUCY F. and LUMB, BRIDGET M., 2015. Differential contributions of A- and C-nociceptors to primary and secondary inflammatory hypersensitivity in the rat PAIN. 156(6), 1074-1083 VENCAPPA S, DONALDSON LF and HULSE RP, 2015. Cisplatin induced sensory neuropathy is prevented by vascular endothelial growth factor-A. American journal of translational research. 7(6), 1032-44 HULSE RP, BEAZLEY-LONG N, VED N, BESTALL SM, RIAZ H, SINGHAL P, BALLMER-HOFER K, HARPER SJ, BATES DO and DONALDSON LF, 2015. Vascular Endothelial Growth Factor (VEGF-A)165b prevents diabetic neuropathic pain and hyperglycaemia-induced sensory neuronal degeneration. Clinical Science. 129(8), 741-56 HSIEH MT, DONALDSON LF and LUMB BM, 2015. Differential contributions of A- and C-nociceptors to primary and secondary inflammatory hypersensitivity in the rat. Pain. 156(6), 1074-83 HUGHES S, HICKEY L, DONALDSON LF, LUMB BM and PICKERING AE, 2015. Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone. Pain. 156(2), 328-34 HULSE RP, BEAZLEY-LONG N, HUA J, KENNEDY H, PRAGER J, BEVAN H, QIU Y, FERNANDES ES, GAMMONS MV, BALLMER-HOFER K, GITTENBERGER DE GROOT AC, CHURCHILL AJ, HARPER SJ, BRAIN SD, BATES DO and DONALDSON LF, 2014. Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia. Neurobiology of disease. (In Press.) DRAKE RAR, HULSE RP, LUMB BM and DONALDSON LF, 2014. The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input. The Journal of physiology. 592(Pt 16), 3611-24 DRAKE, ROBERT A. R., HULSE, RICHARD P., LUMB, BRIDGET M. and DONALDSON, LUCY F., 2014. The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input JOURNAL OF PHYSIOLOGY-LONDON. 592(16), 3611-3624 LEITH, J. LIANNE, WILSON, ALEX W., YOU, HAO-JUN, LUMB, BRIDGET M. and DONALDSON, LUCY F., 2014. Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat JOURNAL OF PHYSIOLOGY-LONDON. 592(22), 5093-5107 HULSE, R. P., BEAZLEY-LONG, N., HUA, J., KENNEDY, H., PRAGER, J., BEVAN, H., QIU, Y., FERNANDES, E. S., GAMMONS, M. V., BALLMER-HOFER, K., DE GROOT, A. C. GITTENBERGER, CHURCHILL, A. J., HARPER, S. J., BRAIN, S. D., BATES, D. O. and DONALDSON, L. F., 2014. Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia NEUROBIOLOGY OF DISEASE. 71, 245-259 LEITH JL, WILSON AW, YOU HJ, LUMB BM and DONALDSON LF, 2014. Periaqueductal grey cyclooxygenase-dependent facilitation of C-nociceptive drive and encoding in dorsal horn neurons in the rat. The Journal of physiology. 592(22), 5093-107 BEAZLEY-LONG, N., HUA, J., JEHLE, T., HULSE, R.P., DERSCH, R., LEHRLING, C., BEVAN, H., QIU, Y., LAGRèZE, W.A., WYNICK, D., CHURCHILL, A.J., KEHOE, P., HARPER, S.J., BATES, D.O. and DONALDSON, L.F., 2013. VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro The American Journal of Pathology. 183(3), 918-929 SRIVASTAVA S, DONALDSON LF, RAI D, MELICHAR JK and POTOKAR J, 2013. Single bright light exposure decreases sweet taste threshold in healthy volunteers. Journal of psychopharmacology (Oxford, England). 27(10), 921-9 GREEN A, KAUL A, O'SHEA J, SHARMA E, BENNETT L, MULLINGS EL, MUNAFò MR, NUTT DJ, MELICHAR JK and DONALDSON LF, 2013. Opiate agonists and antagonists modulate taste perception in opiate-maintained and recently detoxified subjects. Journal of psychopharmacology (Oxford, England). 27(3), 265-75 QIU, Y., SEAGER, M., OSMAN, A., CASTLE-MILLER, J., BEVAN, H., TORTONESE, D. J., MURPHY, D., HARPER, S. J., FRASER, H. M., DONALDSON, L. F. and BATES, D. O., 2012. Ovarian VEGF(165)b expression regulates follicular development, corpus luteum function and fertility: Reproduction Reproduction. 143(4), 501-11 HULSE, R.P., DONALDSON, L.F. and WYNICK, D., 2012. Differential roles of galanin on mechanical and cooling responses at the primary afferent nociceptor Molecular Pain. 8(June), 41 HULSE RP, DONALDSON LF and WYNICK D, 2012. Peripheral galanin receptor 2 as a target for the modulation of pain. Pain research and treatment. 2012, 545386 OLTEAN S, GAMMONS M, HULSE R, HAMDOLLAH-ZADEH M, MAVROU A, DONALDSON L, SALMON AH, HARPER SJ, LADOMERY MR and BATES DO, 2012. SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochemical Society transactions. 40(4), 831-5