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BA Nat.Sci. Class1: (Biochemistry), Cambridge; 1976, D.Phil. Oxford: 1981, Reader in Genetics: Nottingham University: 2000- present

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2016. Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae. BMC Biotechnol.. 16(13), BROWN WRA, THOMAS G, LEE NCO, BLYTHE M, LITI G, WARRINGER J and LOOSE MW, 2014. Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 111(5), 1903-8 XU, Z., THOMAS, L., DAVIES, B., CHALMERS, R., SMITH, M. and BROWN, W., 2013. Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome BMC Biotechnology. 13, 87 BROOKFIELD, R., DAFHNIS-CALAS, F., XU, Z. and BROWN, W., 2012. Unsuccessful attempt at gene-editing by homologous recombination in the zebrafish germ line using the approach of "Rong And Golic" Transgenic Research: Springer. 21(5), 1125-1136 RHIND, N., CHEN, Z., YASSOUR, M., THOMPSON, D.A., HAAS, B.J., HABIB, N., WAPINSKI, I., ROY, S., LIN, M.F., HEIMAN, D.I., YOUNG, S.K., FURUYA, K., GUO, Y., PIDOUX, A. and CHEN, H.M., 2011. Comparative functional genomics of the fission yeasts Science (New York, N.Y.). 332(6032), 930-936 BROWN, W.R.A., LEE, N.C.O., XU, Z. and SMITH, M.C.M., 2011. Serine recombinases as tools for genome engineering Methods. 53(4), 372-379 BROWN, W.R.A., LITI, G., ROSA, C., JAMES, S., ROBERTS, I., ROBERT, V., JOLLY, N., TANG, W., BAUMANN, P., GREEN, C., SCHLEGEL, K., YOUNG, J., HIRCHAUD, F., LEEK, S., THOMAS, G., BLOMBERG, A. and WARRINGER, J., 2011. A geographically diverse collection of Schizosaccharomyces pombe isolates shows limited phenotypic variation but extensive karyotypic diversity G3: Genes, Genomes, Genetics. 1(7), 615-626 DODGSON, J., BROWN, W., ROSA, C.A. and ARMSTRONG, J., 2010. Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation Eukaryotic Cell. 9(11), 1788-1797 BROWN, WILLIAM R. A. and XU, ZHENG-YAO, 2009. The 'kinetochore maintenance loop' - The mark of regulation? BioEssays. 31(2), 228-236 XU, Z, LEE, N. C and DAFHNIS-CALAS, F. MALLA, S. SMITH, M. C.M AND BROWN, W. R.A, 2007. Site-specific recombination in Schizosaccharomyces pombe and systematic assembly of a 400kb transgene array in mammalian cells using the integrase of Streptomyces 'phage phiBT1 Nucleic Acids Research. 36(1), Epub 2007 Dec 20 MALLA, S., DAFHNIS-CALAS, F., BROOKFIELD, J. F., SMITH, M. C. and BROWN, W. R., 2005. Rearranging the centromere of the human Y chromosome with φC31 integrase Nucleic Acids Research. 33(19), 6101-6113 DAFHNIS-CALAS, F., XU, Z., HAINES, S., MALLA, S.K., SMITH, M.C.M. and BROWN, W.R.A., 2005. Iterative in vivo assembly of large and complex transgenes by combining the activities of φC31 integrase and Cre recombinase. Nucleic Acids Research. 33(22), e189 RÉGNIER, V., VAGNARELLI, P., FUKAGAWA, T., ZERJAL, T., BURNS, E., TROUCHE, D., EARNSHAW, W. and BROWN, W., 2005. CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1 Molecular and Cellular Biology. 25(10), 3967-3981 HOLLAND, S., IOANNOU, D., HAINES, S. and BROWN, W.R.A., 2005. Comparison of Dam tagging and chromatin immunoprecipitation as tools for the identification of the binding sites for S. pombe CENP-C. Chromosome Research. 13(1), 73-83 HUBBARD, S. J., GRAFHAM, D. V., BEATTIE, K. J., OVERTON, I. M., MCLAREN, S. R., CRONING, M. D. R., BOARDMAN, P. E., BONFIELD, J. K., BURNSIDE, J., DAVIES, R. M, FARRELL, ER, FRANCIS, MD, GRIFFITH-JONES, S, HUMPHRAY, SJ, SCOTT, CE, TANG, H, TAYLOR, RG, TICKLE, C, BROWN, WR, BIRNEY, E and ROGERS,J>, WILSON, SA, 2005. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags Genome Research. VOL 15(NUMB 1), 174-183 BROWN, W. R. A., HUBBARD, S. J., TICKLE, C. and WILSON, S. A., 2003. The chicken as a model for large-scale analysis of vertebrate gene function Nature Reviews: Genetics. VOL 4(PART 2), 87-98 MEE, P. J., SHEN, M. H., SMITH, A. G. and BROWN, W. R. A., 2003. An unpaired mouse centromere passes consistently through male meiosis and does not significantly compromise spermatogenesis Chromosoma. VOL 112(PART 4), 183-189 KOUPRINA, N., EBERSOLE, T., KORIABINE, M., PAK, E., ROGOZIN, I. B., KATOH, M., OSHIMURA, M., OGI, K., PEREDELCHUK, M. and SOLOMON, G., 2003. Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes Nucleic Acids Research. VOL 31(PART 3), 922-934 RÉGNIER, V., NOVELLI, J., FUKAGAWA, T., VAGNARELLI, P. and BROWN, W., 2003. Characterization of chicken CENP-A and comparative sequence analysis of vertebrate centromere-specific histone H3-like proteins Gene. 316, 39-46 BOARDMAN, P.E., SANZ-EZQUERRO, J., OVERTON, I.M., BURT, D.W., BOSCH, E., FONG, W.T., TICKLE, C., BROWN, W.R.A, WILSON, S.A. and HUBBARD, S.J., 2002. A comprehensive collection of chicken cDNAs Current Biology. 12(22), 1965-1969 FUKAGAWA, T., MIKAMI, Y., NISHIHASHI, A., REGNIER, V., HARAGUCHI, T., HIRAOKA, Y., SUGATA, N., TODOKORO, K., BROWN, W. and IKEMURA, T., 2001. CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells EMBO Journal. 20(16), 4603-4617 SHEN, M. H., YANG, J. W., YANG, J., PENDON, C. and BROWN, W. R., 2000. The accuracy of segregation of human mini-chromosomes varies in different vertebrate cell lines, correlates with the extent of centromere formation and provides evidence for a trans-acting centromere maintenance activity Chromosoma. VOL 109(PART 8), 524-535 YANG, J. W., PENDON, C., YANG, J., HAYWOOD, N., CHAND, A. and BROWN, W. R. A., 2000. Human mini-chromosomes with minimal centromeres Human Molecular Genetics. VOL 9(PART 12), 1891-1902 FUKAGAWA, T. and BROWN, W. R. A., 1997. Efficient conditional mutation of the vertebrate CENP-C gene Human Molecular Genetics. VOL 6(NUMBER 13), 230 HELLER, R., BROWN, K. E., BURGTORF, C. and BROWN, W. R. A., 1996. Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage Proceedings of the National Academy of Sciences of the United States of America. VOL 93(NUMBER 14), 7125-7130

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