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个人简介

In 2013 I moved back to academia and was appointed Associate Professor in Drug discovery in School of Life Sciences.

研究领域

My research interests focus on the role of drug metabolism, pharmacokinetics and physical chemistry in the drug discovery process. In particular understanding these processes at the molecular level and using this information in the design of potential new drugs using in-vitro and in-silico methodologies.

近期论文

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RILEY, R. J., FOLEY, S. A., BARTON, P., SOARS, M. G. and WILLIAMSON, B., 2016. Hepatic drug transporters: the journey so far EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 12(2), 201-216 BARTON P and RILEY RJ, 2015. A new paradigm for navigating compound property related drug attrition. Drug discovery today. 21(1), 72-81 SOARS MG, BARTON P, ELKIN LL, MOSURE KW, SPROSTON JL and RILEY RJ, 2014. Application of an in vitro OAT assay in drug design and optimization of renal clearance. Xenobiotica; the fate of foreign compounds in biological systems. 44(7), 657-65 WENLOCK, M.C. and BARTON, P., 2013. In silico physicochemical parameter predictions Molecular Pharmaceutics. 10(4), 1224-1235 GRIME, K.H., BARTON, P. and MCGINNITY, D.F., 2013. Application of in silico, in vitro and preclinical pharmacokinetic data for the effective and efficient prediction of human pPharmacokinetics Molecular Pharmaceutics. 10(4), 1191-1206 SOARS, M.G., BARTON, P., ISMAIR, M., JUPP, R. and RILEY, R.J., 2012. The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery Drug Metabolism and Disposition. 40(8), 1641-1648 BAHL, A., BARTON, P., BOWERS, K., CAFFREY, M.V., DENTON, R., GILMOUR, P., HAWLEY, S., LINANNEN, T., LUCKHURST, C.A., MOCHEL, T., PERRY, M.W.D., RILEY, R.J., ROE, E., SPRINGTHORPE, B., STEIN, L. and WEBBORN, P., 2012. Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092 Bioorganic & Medicinal Chemistry Letters. 22(21), 6694-6699 BAHL, ASH, BARTON, PATRICK, BOWERS, KEITH, BROUGH, STEVEN, EVANS, RICHARD, LUCKHURST, CHRISTOPHER A., MOCHEL, TOBIAS, PERRY, MATTHEW W. D., RIGBY, AARON, RILEY, ROBERT J., SANGANEE, HITESH, SISSON, ADAM and SPRINGTHORPE, BRIAN, 2012. The discovery of CCR3/H1 dual antagonists with reduced hERG risk: Bioorg. Med. Chem. Lett. Bioorg. Med. Chem. Lett.. 22(21), 6688-6693 WENLOCK, MARK C., POTTER, TIM, BARTON, PATRICK and AUSTIN, RUPERT P., 2011. A method for measuring the lipophilicity of compounds in mixtures of 10: J. Biomol. Screening J. Biomol. Screening. 16(3), 348-355 WENLOCK, MARK C., BARTON, PATRICK and LUKER, TIM, 2011. Lipophilicity of acidic compounds: Impact of ion pair partitioning on drug design: Bioorg. Med. Chem. Lett. Bioorg. Med. Chem. Lett.. 21(12), 3550-3556 WENLOCK, MARK C., BARTON, PATRICK and AUSTIN, RUPERT P., 2011. A kinetic method for the determination of plasma protein binding of compounds unstable in plasma: Specific application to enalapril: J. Pharm. Biomed. Anal. J. Pharm. Biomed. Anal.. 55(3), 385-390 WENLOCK, MARK C., AUSTIN, RUPERT P., POTTER, TIM and BARTON, PATRICK, 2011. A highly automated assay for determining the aqueous equilibrium solubility of drug discovery compounds: J Lab Autom J Lab Autom. 16(4), 276-84 PAINE, STUART W., BARTON, PATRICK, BIRD, JAMES, DENTON, REBECCA, MENOCHET, KARELLE, SMITH, AARON, TOMKINSON, NICHOLAS P. and CHOHAN, KAMALDEEP K., 2010. A rapid computational filter for predicting the rate of human renal clearance: J. Mol. Graphics Modell. J. Mol. Graphics Modell.. 29(4), 529-537 SPRINGTHORPE, BRIAN, BAILEY, ANDREW, BARTON, PATRICK, BIRKINSHAW, TIMOTHY N., BONNERT, ROGER V., BROWN, ROGER C., CHAPMAN, DAVID, DIXON, JOHN, GUILE, SIMON D., HUMPHRIES, ROBERT G., HUNT, SIMON F., INCE, FRANCIS, INGALL, ANTHONY H., KIRK, IAN P., LEESON, PAUL D., LEFF, PAUL, LEWIS, RICHARD J., MARTIN, BARRIE P., MCGINNITY, DERMOT F., MORTIMORE, MICHAEL P., PAINE, STUART W., PAIRAUDEAU, GARRY, PATEL, ANIL, RIGBY, AARON J., RILEY, ROBERT J., TEOBALD, BARRY J., TOMLINSON, WENDY, WEBBORN, PETER J. H. and WILLIS, PAUL A., 2007. From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis: Bioorg. Med. Chem. Lett. Bioorg. Med. Chem. Lett.. 17(21), 6013-6018 BARTON, PATRICK, ed., 2006. In Vitro models for plasma binding and tissue storage: Comprehensive Medicinal Chemistry II Elsevier Ltd.. CHOHAN, KAMALDEEP K., PAINE, STUART W., MISTRY, JAINA, BARTON, PATRICK and DAVIS, ANDREW M., 2005. A Rapid Computational Filter for Cytochrome P450 1A2 Inhibition Potential of Compound Libraries: J. Med. Chem. J. Med. Chem.. 48(16), 5154-5161 AUSTIN, RUPERT P., BARTON, PATRICK, MOHMED, SARFRAZ and RILEY, ROBERT J., 2005. Response to Binding of drugs to Hepatic Microsomes: Comment and assessment of current prediction methodology with recommendation for improvement.: Drug Metab. Dispos. Drug Metab. Dispos.. 34(4), 727 AUSTIN, RUPERT P., BARTON, PATRICK, MOHMED, SARFRAZ and RILEY, ROBERT J., 2005. The binding of drugs to hepatocytes and its relationship to physicochemical properties: Drug Metab. Dispos. Drug Metab. Dispos.. 33(3), 419-425 AUSTIN, RUPERT P., BARTON, PATRICK, DAVIS, ANDREW M., FESSEY, ROGER E. and WENLOCK, MARK C., 2005. The thermodynamics of the partitioning of ionizing molecules between aqueous buffers and phospholipid membranes: Pharm. Res. Pharm. Res.. 22(10), 1649-1657 WENLOCK, MARK C., AUSTIN, RUPERT P., BARTON, PATRICK, DAVIS, ANDREW M. and LEESON, PAUL D., 2003. A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs: J. Med. Chem. J. Med. Chem.. 46(7), 1250-1256 AUSTIN, RUPERT P., BARTON, PATRICK, BONNERT, ROGER V., BROWN, ROGER C., CAGE, PETER A., CHESHIRE, DAVID R., DAVIS, ANDREW M., DOUGALL, IAIN G., INCE, FRANCIS, PAIRAUDEAU, GARRY and YOUNG, ALAN, 2003. QSAR and the Rational Design of Long-Acting Dual D2-Receptor/β2-Adrenoceptor Agonists: J. Med. Chem. J. Med. Chem.. 46(15), 3210-3220 BARTON, PATRICK, HUNTER, CHRISTOPHER A., POTTER, TIMOTHY J., WEBB, SIMON J. and WILLIAMS, NICHOLAS H., 2002. Transmembrane signalling: Angew. Chem., Int. Ed. Angew. Chem., Int. Ed.. 41(20), 3878-3881 AUSTIN, RUPERT P., BARTON, PATRICK, COCKROFT, SCOTT L., WENLOCK, MARK C. and RILEY, ROBERT J., 2002. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties: Drug Metab. Dispos. Drug Metab. Dispos.. 30(12), 1497-1503 AUSTIN, RUPERT P., BARTON, PATRICK, DAVIS, ANDREW M., MANNERS, CAROL N. and STANSFIELD, MICHAEL C., 1998. The Effect of Ionic Strength on Liposome-Buffer and 1-Octanol-Buffer Distribution Coefficients: J. Pharm. Sci. J. Pharm. Sci.. 87(5), 599-607 BARTON, PATRICK, DAVIS, ANDREW M., MCCARTHY, DENNIS J. and WEBBORN, PETER, 1997. Drug-Phospholipid Interactions. 2. Predicting the Sites of Drug Distribution Using n-Octanol/Water and Membrane/Water Distribution Coefficients: J. Pharm. Sci. J. Pharm. Sci.. 86(9), 1034-1039

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