Alexander, Steve - University of Nottingham

研究领域

Research interests include the pharmacology and biochemistry of G-protein-coupled receptors (particularly for adenosine, glutamate and cannabinoids) in isolated tissues and cultured cells; assay of cell signalling-associated enzymes (particularly relating to turnover of endocannabinoids, cyclic nucleotides, gasotransmitters such as NO and hydrogen sulphide, ATP); flavonoids as pharmacologically-active molecules.

近期论文

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2016. Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). (In Press.) PRIESTLEY RS, NICKOLLS SA, ALEXANDER SPH and KENDALL DA, 2015. A potential role for cannabinoid receptors in the therapeutic action of fenofibrate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(4), 1446-55 ALEFISHAT E, ALEXANDER SPH and RALEVIC V, 2015. Effects of NAD at purine receptors in isolated blood vessels. Purinergic signalling. 11(1), 47-57 ERDOZAIN AM, RUBIO M, VALDIZAN EM, PAZOS A, MEANA JJ, FERNáNDEZ-RUIZ J, ALEXANDER SPH and CALLADO LF, 2015. The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects. Addiction biology. 20(4), 773-83 JEAN-GILLES, L., BRAITCH, M., LATIF, M. L., ARAM, J., FAHEY, A. J., EDWARDS, L. J., ROBINS, R. A., TANASESCU, R., TIGHE, P. J., GRAN, B., SHOWE, L. C., ALEXANDER, S. P., CHAPMAN, V., KENDALL, D. A. and CONSTANTINESCU, C. S., 2015. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells Acta Physiologica. 214(1), 63-74 ALEXANDER, STEPHEN P. H., KELLY, EAMONN, MARRION, NEIL, PETERS, JOHN A., BENSON, HELEN E., FACCENDA, ELENA, PAWSON, ADAM J., SHARMAN, JOANNA L., SOUTHAN, CHRISTOPHER and DAVIES, JAMIE A., 2015. THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Other ion channels BRITISH JOURNAL OF PHARMACOLOGY. 172(24), 5942-5955 ALEXANDER, STEPHEN P. H., KELLY, EAMONN, MARRION, NEIL, PETERS, JOHN A., BENSON, HELEN E., FACCENDA, ELENA, PAWSON, ADAM J., SHARMAN, JOANNA L., SOUTHAN, CHRISTOPHER and DAVIES, JAMIE A., 2015. THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Transporters BRITISH JOURNAL OF PHARMACOLOGY. 172(24), 6110-6202 DUNN WR, ALEXANDER SP, RALEVIC V and ROBERTS RE, 2015. Effects of hydrogen sulphide in smooth muscle. Pharmacology & therapeutics. 158, 101-13 SOUTHAN C, SHARMAN JL, BENSON HE, FACCENDA E, PAWSON AJ, ALEXANDER SP, BUNEMAN OP, DAVENPORT AP, MCGRATH JC, PETERS JA, SPEDDING M, CATTERALL WA, FABBRO D, DAVIES JA and , 2015. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic acids research. 44(D1), D1054-68 ALEXANDER SP, 2015. Therapeutic potential of cannabis-related drugs. Progress in neuro-psychopharmacology & biological psychiatry. 64, 157-66 CABLE JC, TAN GD, ALEXANDER SP and O'SULLIVAN SE, 2014. The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes Lipids Health Dis. 4(13), 43 HASSAN S, ELDEEB K, MILLNS PJ, BENNETT AJ, ALEXANDER SPH and KENDALL DA, 2014. Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation. British journal of pharmacology. 171(9), 2426-39 CABLE JC, TAN GD, ALEXANDER SPH and O'SULLIVAN SE, 2014. The effects of obesity, diabetes and metabolic syndrome on the hydrolytic enzymes of the endocannabinoid system in animal and human adipocytes. Lipids in health and disease. 13, 43 GASKIN PL, ALEXANDER SP and FONE KC, 2014. Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology. 231(12), 2533-45 PAWSON AJ, SHARMAN JL, BENSON HE, FACCENDA E, ALEXANDER SPH, BUNEMAN OP, DAVENPORT AP, MCGRATH JC, PETERS JA, SOUTHAN C, SPEDDING M, YU W, HARMAR AJ and NC-IUPHAR, 2014. The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic acids research. 42(Database issue), D1098-106 WONG PS, GARLE MJ, ALEXANDER SPH, RANDALL MD and ROBERTS RE, 2014. A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological research : the official journal of the Italian Pharmacological Society. 90, 25-35 WONG, P. S., GARLE, M. J., ALEXANDER, S. P. H., RANDALL, M. D. and ROBERTS, R. E., 2014. A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries PHARMACOLOGICAL RESEARCH. 90, 25-35 ALEFISHAT, E., ALEXANDER, S.P.H. and RALEVIC, V., 2013. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate British Journal of Pharmacology. 168(8), 1911-1922 RASHID, S., HEER, J.K., GARLE, M.J., ALEXANDER, S.P.H. and ROBERTS, R.E., 2013. Hydrogen sulphide-induced relaxation of porcine peripheral bronchioles British Journal of Pharmacology. 168(8), 1902-1910 ZACHARIOU, M., ALEXANDER, S.P.H., COOMBES, S. and CHRISTODOULOU, C., 2013. A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition PLoS One. 8(3), e58926 DAVENPORT AP, ALEXANDER SPH, SHARMAN JL, PAWSON AJ, BENSON HE, MONAGHAN AE, LIEW WC, MPAMHANGA CP, BONNER TI, NEUBIG RR, PIN JP, SPEDDING M and HARMAR AJ, 2013. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacological reviews. 65(3), 967-86 ROBERTS RE, ALLEN S, CHANG APY, HENDERSON H, HOBSON GC, KARANIA B, MORGAN KN, PEK ASY, RAGHVANI K, SHEE CY, SHIKOTRA J, STREET E, ABBAS Z, ELLIS K, HEER JK and ALEXANDER SPH, 2013. Distinct mechanisms of relaxation to bioactive components from Chamomile species in porcine isolated blood vessels. Toxicology and applied pharmacology. (In Press.) ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. The Concise Guide to PHARMACOLOGY 2013/14: enzymes. British journal of pharmacology. 170(8), 1797-867 ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. The Concise Guide to PHARMACOLOGY 2013/14: transporters. British journal of pharmacology. 170(8), 1706-96 ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors. British journal of pharmacology. 170(8), 1676-705