Sewell, Herbert - University of Nottingham

研究领域

My current research interests focuses mainly on translational human cancer studies. Working with collaborators in the universities interdisciplinary Centre of Excellence for Autoimmunity in Cancer (CEAC - Director Professor JF Robertson) studies are pursued in the area of autoimmunity in cancer and its role in early detection and in guiding therapy/patient stratification. The research relies on detection of in vivo generated human auto immune responses to cancer tumour associated antigens (TAA's). In collaboration with the biotechnology industry we have already developed a test which has moved from the 'bench to the bedside' enabling the early detection of lung cancer. The test is currently in clinical use and has already shown that within high risk populations that cancers can be detected early whilst they are still treatable with the potential for increased patient survival and indeed in some cases cure. Our initial tests called 'Early CDT-Lung' represents a world first, current usage in clinical practice has confirmed findings predicted from our published retrospective studies (see publications). CEAC is pursuing research to enable the early detection of other solid cancers including breast, ovarian, colorectal and pancreatic cancers.

近期论文

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WEJDAN A ALDAJANI, FABIáN SALAZAR, HERB F SEWELL, ALAN KNOX and AMIR M GHAEMMAGHAMI, 2016. Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget. 7(36), 57606-57617 MASSION PP, HEALEY GF, PEEK LJ, FREDERICKS L, SEWELL HF, MURRAY A and ROBERTSON JF, 2016. Autoantibody Signature Enhances the Positive Predictive Power of Computed Tomography and Nodule-Based Risk Models for Detection of Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. (In Press.) NEGM OH, HAMED MR, SCHOEN RE, WHELAN RL, STEELE RJ, SCHOLEFIELD J, DILNOT EM, SHANTHA KUMARA HM, ROBERTSON JF and SEWELL HF, 2016. Human Blood Autoantibodies in the Detection of Colorectal Cancer. PloS one. 11(7), e0156971 SULLIVAN, FRANK, DORWARD, ALISTAIR, MAIR, FRANCES, SCHEMBRI, STUART, ROBERTSON, JOHN, VEDHARA, KAVITA, KENDRICK, DENISE, SEWELL, HERB, TREWEEK, SHAUN, MCCOWAN, COLIN, ROBERTSON, CHRIS, SPROULE, MIKE, BRIGGS, ANDY, RITCHIE, LEWIS, MILROY, ROBERT, TAYLOR, TOM, LITTLEFORD, ROBERTA and BREWSTER, DAVID, 2014. A new partnership with biomarker research: a randomised controlled trial of the detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT-Lung test in Scotland (ECLS) EUROPEAN JOURNAL OF CANCER CARE. 23, 31-31 MACDONALD, I.K., MURRAY, A., HEALEY, G.F., PARSY-KOWALSKA, C.B., ALLEN, J., MCELVEEN, J., ROBERTSON, C., SEWELL, H.F., CHAPMAN, C.J. and ROBERTSON, J.F.R., 2012. Application of a high throughput method of biomarker discovery to improvement of the EarlyCDT(?)-Lung test PLoS ONE. 7(12), e51002 MACDONALD, I.K., ALLEN, J., MURRAY, A., PARSY-KOWALSKA, C.B., HEALEY, G.F., CHAPMAN, C.J., SEWELL, H.F. and ROBERTSON, J.F.R., 2012. Development and validation of a high throughput system for discovery of antigens for autoantibody detection PLoS ONE. 7(7), e40759 EMARA, M., ROYER, P-J., ABBAS, Z., SEWELL, H.F., GEBRIEL MOHAMED, G., SINGH, S., PEEL, S., FOX, J., SHAKIB, F., MARTINEZ-POMARES, L. and GHAEMMAGHAMI, A.M., 2011. Recognition of the major cat allergen Fel d 1 through the cysteine-rich domain of the mannose receptor determines its allergenicity The Journal of Biological Chemistry. 286(15), 13033-13040 LAM, S., BOYLE, P., HEALEY, G.F., MADDISON, P., PEEK, L., MURRAY, A., CHAPMAN, C.J., ALLEN, J., WOOD, W.C., SEWELL, H.F. and ROBERTSON, J.F.R., 2011. EarlyCDT-Lung: an immunobiomarker test as an aid to early detection of lung cancer Cancer Prevention Research. 4(7), 1126-1134 MODI, N., GULATI, N., SOLOMON, K., MONAGHAN, T., ROBINS, A., SEWELL, H.F. and MAHIDA, Y.R., 2011. Differential binding and internalization of clostridium difficile toxin A by human peripheral blood monocytes, neutrophils and lymphocytes Scandinavian Journal of Immunology. 74(3), 264-271 ROYER, PIERRE-JOSEPH, EMARA, MOHAMED, YANG, CHAOXING, AL-GHOULEH, ABEER, TIGHE, PADDY, JONES, NICK, SEWELL, HERB F, SHAKIB, FAROUK, MARTINEZ-POMARES, LUISA and GHAEMMAGHAMI, AMIR M, 2010. The Mannose Receptor Mediates the Uptake of Diverse Native Allergens by Dendritic Cells and Determines Allergen-Induced T Cell Polarization through Modulation of IDO Activity. Journal of immunology (Baltimore, Md. : 1950). MURRAY, A., CHAPMAN, C.J., HEALEY, G., PEEK, L.J., PARSONS, G., BALDWIN, D., BARNES, A., SEWELL, H.F., FRITSCHE, H.A. and ROBERTSON, J.F.R., 2010. Technical validation of an autoantibody test for lung cancer Annals Of Oncology. 21(8), 1687-1693 HASAN, A.A., GHAEMMAGHAMI, A.M., FAIRCLOUGH, L., ROBINS, A., SEWELL, H.F. and SHAKIB, F., 2009. Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function Immunobiology. 214(1), 2-16 HORLOCK,, SHAKIB,, JONES,, SEWELL, and GHAEMMAGHAMI,, 2009. Differential Protein Expression by Dendritic Cells from Atopic and Non-Atopic Individuals after Stimulation by the Major House Dust Mite Allergen Der p 1. International archives of allergy and immunology. 150(3), 237-251 WIGGINTON, S.J., FURTADO, P.B., ARMOUR, K.L., CLARK, M.R., ROBINS, A., EMARA, M., GHAEMMAGHAMI, A.M., SEWELL, H.F. and SHAKIB, F., 2008. An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of Fc?RI with FcγRIIb Clinical & Experimental Allergy. 38(2), 313-319 SHAKIB,, GHAEMMAGHAMI, and SEWELL,, 2008. The molecular basis of allergenicity. Trends in immunology. 29(12), 633-642 RICHENS, J., FAIRCLOUGH, L., GHAEMMAGHAMI, A.M., MAHDAVI, J., SHAKIB, F. and SEWELL, H.F., 2007. The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets Immunobiology. 212(1), 29-38 FURMONAVICIENE, R., GHAEMMAGHAMI, A.M., BOYD, S.E., JONES, N.S., BAILEY, K., WILLIS, A.C., SEWELL, H.F., MITCHELL, D.A. and SHAKIB, F., 2007. The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses Clinical and experimental allergy: Journal of the British Society for Allergy and Clinical Immunology. 37(2), 231-242 HORLOCK, C., SHAKIB, F., MAHDAVI, J., JONES, N.S., SEWELL, H.F. and GHAEMMAGHAMI, A.M., 2007. Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell like KG-1 cells reveals distinct characteristics Genome Biology. 8(3), R30 FURMONAVICIENE, R., SUTTON, B.J., GLASER, F., LAUGHTON, C.A., JONES, N., SEWELL, H.F. and SHAKIB, F., 2005. An attempt to define allergen-specific molecular surface features: a bioinformatic approach Bioinformatics. 21(23), 4201-4204 FURTADO, P.B., MCELVEEN, J.E., GOUGH, L., ARMOUR, K.L., CLARK, M.R., SEWELL, H.F. and SHAKIB, F., 2002. The production and characterisation of a chimaeric human IgE antibody, recognising the major mite allergen Der p 1, and its chimaeric human IgG1 anti-idiotype Molecular Pathology. 55(5), 315-324 GHAEMMAGHAMI, A.M., GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2002. The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level Clinical and Experimental Allergy. 32(10), 1468-1475