Sablitzky, Fred - University of Nottingham

个人简介

Diplom in Biology, University of Cologne (1981) - PhD Genetics/Immunology, University of Cologne, Fellowship 'Fonds der Chemischen Industrie' (1985) - Habilitation (venia legendi) in Genetics, University of Cologne (1996) - Research Fellow in Immunology, University of Cologne (1985-1987) - Research Fellow in Haematopoiesis, Hospital For Sick Children, University of Toronto, Fellowship 'Deutsche Forschungsgemeinschaft' (1987-1989) - Head of Developmental Haematology Unit, Max-Delbrück-Laboratory, Max-Planck Society, Cologne, 'Nachwuchsförderung, Budesministerium für Bildung und Forschung', scientific award 'Bennigsen-Foerder-Preis des Landes NRW' (1989-1995) - Wellcome Trust European Senior Research Fellow, Department of Medicine, University College London (UCL), London (1995-1999) - Reader in Molecular Genetics, Department of Medicine, UCL, London (1998-1999) - Professor of Genetics and Scientific Director of the Gene Targeting & Transgenic Unit, Genetics (1999), School of Biology (2003), School of Life Sciences (2013), Molecular Cell & Developmental Biology, The University of Nottingham.

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HELSEL, A.R., YANG, Q.-E., OATLEY, M.J., LORD, T., SABLITZKY, F. and OATLEY, J.M., 2017. ID4 levels dictate the stem cell state in mouse spermatogonia. Development. 144(4), 624-634 XU, X., SHUEN, W. H., CHEN, C., GOUDEVENOU, K, JONES, P. and SABLITZKY, F., 2014. Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signaling and RhoA effector function Developmental Biology. 386(1), 191-203 HEY, F., CZYZEWICZ, N., JONES, P. and SABLITZKY, F., 2012. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localise with P-bodies The Journal of Biological Chemistry. 287(37), 31073-31084 HUGHES, K.R., G?NDARA, R.M.C., JAVKAR, T., SABLITZKY, F., HOCK, H., POTTEN, C.S. and MAHIDA, Y.R., 2012. Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon. Am J Physiol Gastrointest Liver Physiol. 303(11), G1188-1201 HUGHES, K.R., SABLITZKY, F. and MAHIDA, Y.R., 2011. Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells Inflammatory Bowel Diseases. 17(1), 213-220 CHEN, S.-S., CLAUS, R., LUCAS, D.M., YU, L., QIAN, J., RUPPERT, A.S., WEST, D.A., WILLIAMS, K.E., JOHNSON, A.J., SABLITZKY, F., PLASS, C. and BYRD, J.C., 2011. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL Blood. 117(3), 862-871 CAPRON, C., LACOUT, C., LéCLUSE, Y., WAGNER-BALLON, O., KAUSHIK, A.L., CRAMER-BORDé, E., SABLITZKY, F., DUMéNIL, D. and VAINCHENKER, W., 2011. LYL-1 deficiency induces a stress erythropoiesis. Experimental Hematology. 39(6), 629-642 DONG, J, HUANG, S., CAIKOVSKI, M., JI, S., MCGRATH, A., CUSTORIO, M.G., CREIGHTON, C.J., MALIAKKAL, P., BOGOSLOVSKAIA, E., DU, Z., ZHANG, X., LEWIS, M.T., SABLITZKY, F., BRISKEN, C. and LI, Y., 2011. ID4 regulates mammary gland development by suppressing p38MAPK activity Development. 138, 5247-5256 GOUDEVENOU, K., MARTIN, P., YEH, Y-J., JONES, P. and SABLITZKY, F., 2011. Def6 is required for convergent extension movements during zebrafish gastrulation downstream of Wnt5b signaling PLoS One. 6(10), e26548 HEATH, E., SABLITZKY, F. and MORGAN, G.T., 2010. Subnuclear targeting of the RNA-binding motif protein RBM6 to splicing speckles and nascent transcripts Chromosome Research. 18(8), 851-872 PIROT, N., DELEUZE, V., EL-HAJJ, R., DOHET, C., SABLITZKY, F., COUTTET, P., MATHIEU, D. and PINET, V., 2010. LYL activity is required for the maturation of newly formed blood vessels in adulthood Blood. 115(25), 5270-5279 TOKUZAWA, Y., YAGI, K., YAMASHITA, Y., NAKACHI, Y., NIKAIDO, I., BONO, H., NINOMIYA, Y., KANESAKI-YATSUKA, Y., AKITA, M., MOTEGI, H., WAKANA, S., NODA, T., SABLITZKY, F., ARAI, S., KUROKAWA, R., FUKUDA, T., KATAGIRI, T., SCH?NBACH, C., SUDA, T., MIZUNO, Y. and OKAZAKI, Y., 2010. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation PLoS Genetics. 6(7), e1001019 SOUROULLAS, G.P., SALMON, J.M., SABLITZKY, F., CURTIS, D.J. and GOODELL, M.A., 2009. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival Cell Stem Cell. 4(2), 180-186 CHAN, W.Y.I., FOLLOWS, G.A., LACAUD, G., PIMANDA, J.E., LANDRY, ,J.-R., KINSTON, S., KNEZEVIC, K., PILTZ, S., DONALDSON, I.J., GAMBARDELLA, L., SABLITZKY, F., GREEN, A.R., KOUSKOFF, V. and G?TTGENS, B., 2007. The paralogous haemopoietic regulators Lyl1 and Scl are co-regulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype Blood. 109(5), 1908-1916 GIROUX, S., KAUSHIK, A-L., CAPRON, C., JALIL, A., KELAIDI, C., SABLITZKY, F., DUMENIL, D., ALBAGLI, O. and GODIN, I., 2007. lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny. Gene Expression Patterns. 7(3), 215-226 CAPRON, C., LéCLUSE, Y., KAUSHIK, A. L., FOUDI, A., LACOUT, C., SEKKAI, D., GODIN, I., ALBAGLI, O., POULLION, I., SVINARTCHOUK, F., SCHANZE, E., VAINCHENKER, W., SABLITZKY, F., BENNACEUR-GRISCELLI, A. and DUMéNIL, D., 2006. The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation Blood. 107(12), 4678-4686 MARIN-HUSSTEGE, M., HE, Y., LI, J., KONDO, T., SABLITZKY, F. and CASACCIA-BONNEFIL, P., 2006. Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings Glia. 54(4), 285-296 SABLITZKY,F., 2006. Id4 Nature Publishing Group, London. Available at: GARRATT, L.C., ORTORI, C.A., TUCKER, G.A., SABLITZKY, F., BENNETT, M.J. and BARRETT, D.A., 2005. Comprehensive metabolic profiling of mono- and polyglutamated folates and their precursors in plant and animal tissue using liquid chromatography/negative ion electrospray ionisation tandem mass spectrometry Rapid Communications in Mass Spectrometry. 19(17), 2390-2398 BEDFORD, L., WALKER, R., KONDO, T., VAN CRüCHTEN, I., KING, E. R. and SABLITZKY, F., 2005. Id4 is required for the correct timing of neural differentiation Developmental Biology. 280(2), 386-395 SABLITZKY,F., 2005. Protein motifs: the helix-loop-helix motif. In: Encyclopedia of Life Sciences (Online) John Wiley & Sons, Chichester, UK. (5 pages) MAVRAKIS, K.J., MCKINLAY, K.J., JONES, P. and SABLITZKY, F., 2004. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA Experimental Cell Research. 294(2), 335-344 AHMED, B.Y., CHAKRAVARTHY, S., EGGERS, R., HERMENS, W.T.J.M.C, ZHANG, J.Y., NICLOU, S.P., LEVELT, C., SABLITZKY, F., ANDERSON, P.N., LIEBERMAN, A R and VERHAAGEN, J., 2004. Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors. BMC Neuroscience. 5, 4 CINATO, E., MIROTSOU, M. and SABLITZKY, F., 2001. Cre-mediated transgene activation in the developing and adult mouse brain Genesis. 31(3), 118-129 HENG, Y M, FOX, M and SABLITZKY, F, 2000. Assignment of the murine def-3 gene (Rbm6) to chromosome 9F1-F2 and its pseudogenes Rbm6-ps1 and Rbm6-ps2 to chromosome 1 by in situ hybridisation. Cytogenetics and Cell Genetics. 89(3-4), 238-9