Hill, Stephen - University of Nottingham

个人简介

Stephen Hill studied Pharmacology in Bristol (BSc, 1976) and then undertook PhD studies in the Department of Pharmacology in Cambridge (PhD 1979, first demonstration of 3H-mepyramine binding to histamine H1-receptors). After postdoctoral studies in Cambridge (1979-1981) he was appointed to a lecturer position in the Department of Pharmacy at the University of Nottingham. He joined the Department of Physiology and Pharmacology (now the School of Biomedical Sciences) in 1984 and was subsequently promoted to Reader (1989) and Professor of Molecular Pharmacology (1995). He was Head of the School of Biomedical Sciences from 2008-2013. He was Director of the Institute of Cell Signalling from 1997-2008 and in 2016 became the inaugural Nottingham Co-Director of the University of Birmingham and University of Nottingham Centre of Membrane Proteins and Receptors. He is also Adjunct Professor at the Harry Perkins's Institute, University of Western Australia where he also holds a Raine Foundation Visiting Research Professorship. He was a founding director of the University of Nottingham spin-out company CellAura Technologies Ltd that provided fluorescent ligands to the scientific community. He has served on the Editorial Boards of the British Journal of Pharmacology and Current Opinion on Pharmacology. He was Vice-President (Meetings) of the British Pharmacological Society (2004-2006) and was the BPS Sandoz (Novartis) Prize winner in 1987 and the BPS Australasian Lecturer in 2006. He was elected a Fellow of the British Pharmacological Society in 2004 and is currently President-Elect of the British Pharmacological Society.

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SOAVE M, STODDART LA, BROWN A, WOOLARD J and HILL SJ, 2016. Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells. Pharmacology research & perspectives. 4(5), e00250 HOTHERSALL JD, GUO D, SARDA S, SHEPPARD RJ, CHEN H, KEUR W, WARING MJ, IJZERMAN AP, HILL SJ, DALE IL and RAWLINS PB, 2016. Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics. Molecular pharmacology. 91(1), 25-38 KILPATRICK LE and HILL SJ, 2016. The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors. Biochemical Society transactions. 44(2), 624-9 BAKER JG, PROUDMAN RGW and HILL SJ, 2015. Salmeterol's Extreme β2 Selectivity Is Due to Residues in Both Extracellular Loops and Transmembrane Domains. Molecular pharmacology. 87(1), 103-20 STODDART, LEIGH A., JOHNSTONE, ELIZABETH K. M., WHEAL, AMANDA J., GOULDING, JOELLE, ROBERS, MATTHEW B., MACHLEIDT, THOMAS, WOOD, KEITH V., HILL, STEPHEN J. and PFLEGER, KEVIN D. G., 2015. Application of BRET to monitor ligand binding to GPCRs NATURE METHODS. 12(7), 661-663 GHERBI, KAROLINA, MAY, LAUREN T., BAKER, JILLIAN G., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2015. Negative cooperativity across beta(1)-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 beta(1)-adrenoceptor binding conformation FASEB JOURNAL. 29(7), 2859-2871 CARTER, JOANNE J., WHEAL, AMANDA J., HILL, STEPHEN J. and WOOLARD, JEANETTE, 2015. Effects of receptor tyrosine kinase inhibitors on VEGF(165)a- and VEGF(165)b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2 BRITISH JOURNAL OF PHARMACOLOGY. 172(12), 3141-3150 STODDART, LEIGH A., VERNALL, ANDREA J., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2015. Direct visualisation of internalization of the adenosine A(3) receptor and localization with arrestin3 using a fluorescent agonist NEUROPHARMACOLOGY. 98, 68-77 STODDART, LEIGH A., KILPATRICK, LAURA E., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2015. Probing the pharmacology of G protein-coupled receptors with fluorescent ligands NEUROPHARMACOLOGY. 98, 48-57 HOFFMANN, C., CASTRO, M., RINKEN, A., LEURS, R., HILL, S. J. and VISCHER, H. F., 2015. Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It MOLECULAR PHARMACOLOGY. 88(3), 552-560 RANGANATHAN, ANIRUDH, STODDART, LEIGH A., HILL, STEPHEN J. and CARLSSON, JENS, 2015. Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models JOURNAL OF MEDICINAL CHEMISTRY. 58(24), 9578-9590 VAN UNEN, JAKOBUS, WOOLARD, JEANETTE, RINKEN, AGO, HOFFMANN, CARSTEN, HILL, STEPHEN J., GOEDHART, JOACHIM, BRUCHAS, MICHAEL R., BOUVIER, MICHEL and ADJOBO-HERMANS, MEREL J. W., 2015. A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms MOLECULAR PHARMACOLOGY. 88(3), 589-595 HUTCHINGS, CATHERINE J., CSEKE, GABRIELLA, OSBORNE, GREG, WOOLARD, JEANETTE, ZHUKOV, ANDREI, KOGLIN, MARKUS, JAZAYERI, ALI, PANDYA-PATHAK, JAHNAVI, LANGMEAD, CHRISTOPHER J., HILL, STEPHEN J., WEIR, MALCOLM and MARSHALL, FIONA H., 2014. Monoclonal anti-beta(1)-adrenergic receptor antibodies activate G protein signaling in the absence of beta-arrestin recruitment MABS. 6(1), 246-261 VERNALL, ANDREA J., HILL, STEPHEN J. and KELLAM, BARRIE, 2014. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1073-1084 STODDART, LEIGH A., KELLAM, BARRIE, BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2014. Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization BRITISH JOURNAL OF PHARMACOLOGY. 171(16), 3827-3844 HILL, STEPHEN J., MAY, LAUREN T., KELLAM, BARRIE and WOOLARD, JEANETTE, 2014. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization BRITISH JOURNAL OF PHARMACOLOGY. 171(5), 1102-1113 BAKER, JILLIAN G., PROUDMAN, RICHARD G. W. and HILL, STEPHEN J., 2014. Identification of Key Residues in Transmembrane 4 Responsible for the Secondary, Low-Affinity Conformation of the Human beta(1)-Adrenoceptor MOLECULAR PHARMACOLOGY. 85(5), 811-829 GHERBI K, BRIDDON SJ and HILL SJ, 2014. Detection of the secondary low affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. British journal of pharmacology. 171, 5431-5445 CORRIDEN R, KILPATRICK LE, KELLAM B, BRIDDON SJ and HILL SJ, 2014. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB journal. 28, 4211-4222 JAEGER WC, ARMSTRONG SP, HILL SJ and PFLEGER KDG, 2014. Biophysical Detection of Diversity and Bias in GPCR Function. Frontiers in endocrinology. 5, 26 STODDART LA, KELLAM B, BRIDDON SJ and HILL SJ, 2014. Effect of a toggle switch mutation in TM6 of the human adenosine A? receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British journal of pharmacology. 171(16), 3827-44 CORRIDEN, ROSS, KILPATRICK, LAURA E., KELLAM, BARRIE, BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2014. Kinetic analysis of antagonist-occupied adenosine-A(3) receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism FASEB JOURNAL. 28(10), 4211-4222 CORRIDEN, R., SELF, T., AKONG-MOORE, K., NIZET, V., KELLAM, B., BRIDDON, S.J. and HILL, S.J., 2013. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes EMBO Reports. 14(8), 726-732 MISTRY, S.N., BAKER, J.G., FISCHER, P.M., HILL, S.J., GARDINER, S.M. and KELLAM, B., 2013. Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists Journal of Medicinal Chemistry. 56(10), 3852-3865 VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & biomolecular chemistry. 11(34), 5673-82