Fone, Kevin - University of Nottingham - School of Life Sciences

个人简介

I graduated from Liverpool University in 1980 with a BSc in Pharmacology and continued in the same department to obtain a PhD on the central control of respiration in 1984. I then moved to the University of Nottingham and commenced an MRC post doctoral research fellowship with Professor CA Marsden and Dr GW Bennett, examining the role of serotonin (5-HT) in bulbospinal raphe neurones controlling motor function. This established my long-standing interest in the mechanism of action of 5-HT in the CNS and Nottingham has since been my home for this research. In 1988 I was appointed to the position of Lecturer in the Department of Physiology and Pharmacology and I became a Senior lecturer in 1996, a Reader in 2003, and obtained a personal Chair in 2006 in what was then the School of Biomedical Sciences. I was elected a fellow of the British Pharmacological Society in 2012.

研究领域

My research interest is the role of 5-hydroxytryptamine and dopamine in neurological and mental disorders and the impact of lesions, pharmacological or environmental interventions during early-life on subsequent behavioural and neuronal development. My particular research focus is on the development and assessment of predictive models for schizophrenia, ADHD, depression and anxiety, and cognitive disorders. The fundamental approach is to concomitantly measure neurotransmitter function, neurochemistry and behaviour in paradigms designed to model CNS disorders. Techniques used include behavioural analysis, immunohistochemistry, radiotelemetry, microdialysis, electrophysiology, and MRI to identify changes in neuronal circuits in the brain that underlie the alterations in behaviour and neurophysiology seen. The aim is to gain a better understanding of the neurobiological aetiology of common CNS disorders and to help develop novel therapeutic treatment strategies.

近期论文

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RAFTER M, FONE KCF and MORAN PM, 2016. Glutamate pharmacological models relevant to schizophrenia and psychosis: Can a receptor occupancy normalisation approach reduce the gap between animal and human experiments?. In: Handbook of Behavioural Neuroscience, Modeling Psychopathological Dimensions of Psychiatry: Glutamate pharmacological models relevant to schizophrenia and psychosis: Can a receptor occupancy normalisation approach reduce the gap between animal and human experiments? Elsevier. (In Press.) SHORTALL SE, GREEN AR, FONE KC and KING MV, 2016. Caffeine alters the behavioural and body temperature responses to mephedrone without causing long-term neurotoxicity in rats. Journal of psychopharmacology (Oxford, England). 30(7), 698-706 WATSON DJ, KING MV, GYERTYáN I, KISS B, ADHAM N and FONE KC, 2016. The dopamine D?-preferring D?/D? dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(2), 208-24 2016. Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone. Addiction biology. 21(6), 1127-1139 2016. Down-regulation of hippocampal genes regulating dopaminergic, GABAergic and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). (In Press.) MCGARRITY S, MASON R, FONE KC, PEZZE M and BAST T, 2016. Hippocampal Neural Disinhibition Causes Attentional and Memory Deficits. Cerebral cortex (New York, N.Y. : 1991). (In Press.) PEZZE MA, MARSHALL HJ, FONE KC and CASSADAY HJ, 2015. Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: Role of the prelimbic cortex. European Neuropsychopharmacology: Eur Neuropsychopharmacol. 25(11), 2145-56 SHORTALL SE, SPICER CH, EBLING FJ, GREEN AR, FONE KC and KING MV, 2015. Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone. Addiction Biology. [Epub ahead of print], ISLAHUDIN F, TINDALL SM, MELLOR IR, SWIFT K, CHRISTENSEN HEM, FONE KCF, PLEASS RJ, TING K and AVERY SV, 2014. The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific Reports. 4, 3618 GREEN AR, KING MV, SHORTALL SE and FONE KCF, 2014. The preclinical pharmacology of mephedrone; not just MDMA by another name. British Journal of Pharmacology. 171(9), 2251-2268 JONES S, FILECCIA EL, MURPHY M, FOWLER MJ, KING MV, SHORTALL SE, WIGMORE PM, GREEN AR, FONE KCF and EBLING FJP, 2014. Cathinone increases body temperature, enhances locomotor activity, and induces striatal c-fos expression in the Siberian hamster. Neuroscience letters. 559, 34-8 GASKIN PL, ALEXANDER SP and FONE KC, 2014. Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology. 231(12), 2533-45 PEZZE M, MCGARRITY S, MASON R, FONE KC and BAST T, 2014. Too Little and Too Much: Hypoactivation and Disinhibition of Medial Prefrontal Cortex Cause Attentional Deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(23), 7931-7946 MILLAN MJ, FONE K, STECKLER T and HORAN WP, 2014. Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 24(5), 645-92 NAPOLITANO, ANTONIO, SHAH, KHALID, SCHUBERT, MIRJAM I., PORKESS, VERONICA, FONE, KEVIN C. F. and AUER, DOROTHEE P., 2014. In Vivo Neurometabolic Profiling to Characterize the Effects of Social Isolation and Ketamine-Induced NMDA Antagonism: A Rodent Study at 7.0 T SCHIZOPHRENIA BULLETIN. 40(3), 566-574 KING, MADELEINE V., KURIAN, NISHA, QIN, SI, PAPADOPOULOU, NEKTARIA, WESTERINK, BEN H. C., CREMERS, THOMAS I., EPPING-JORDAN, MARK P., LE POUL, EMMANUEL, RAY, DAVID E., FONE, KEVIN C. F., KENDALL, DAVID A., MARSDEN, CHARLES A. and SHARP, TYSON V., 2014. Lentiviral Delivery of a Vesicular Glutamate Transporter 1 (VGLUT1)-Targeting Short Hairpin RNA Vector Into the Mouse Hippocampus Impairs Cognition NEUROPSYCHOPHARMACOLOGY. 39(2), 464-476 GASKIN, PHILIP L. R., ALEXANDER, STEPHEN P. H. and FONE, KEVIN C. F., 2014. Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat PSYCHOPHARMACOLOGY. 231(12), 2533-2545 SHORTALL, S.E., GREEN, A.R., SWIFT, K.M., FONE, K.C.F. and KING, M.V., 2013. Differential effects of cathinone compounds and MDMA on body temperature in the rat, and pharmacological characterisation of mephedrone-induced hypothermia British Journal of Pharmacology. 168(4), 966-977 SHORTALL, S.E., MACEROLA, A.E., SWABY, R.T.R., JAYSON, R., KORSAH, C., PILLIDGE, K.E., WIGMORE, P.M., EBLING, F.J.P., GREEN, A.R., FONE, K.C.F. and KING, M.V., 2013. Behavioural and neurochemical comparison of chronic intermittent cathinone, mephedrone and MDMA administration to the rat European Neuropsychopharmacology. 23(9), 1085-1095 MCINTOSH, A.L., BALLARD, T.M., STEWARD, L.J., MORAN, P.M. and FONE, K.C.F., 2013. The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats Psychopharmacology. 228(1), 31-42 BODY S, CHEUNG THC, VALENCIA-TORRES L, OLARTE-SáNCHEZ CM, FONE KCF, BRADSHAW CM and SZABADI E, 2013. Pharmacological studies of performance on the free-operant psychophysical procedure. Behavioural processes. 95, 71-89 BAY-RICHTER, C., O'CALLAGHAN, M.J., MATHUR, N., O'TUATHAIGH, C.M.P., HEERY, D.M., FONE, K.C.F, WADDINGTON, J.L. and MORAN, P.M., 2013. D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors Neuropsychopharmacology. 38(8), 1512-1520 NAPOLITANO, A., SHAH, K., SCHUBERT, M.I., PORKESS, V., FONE, K.C.F. and AUER, D.P., 2013. In vivo neurometabolic profiling to characterize the effects of social isolation and ketamine-induced NMDA antagonism: a rodent study at 7.0 T Schizophrenia Bulletin. n/a(n/a), n/a KING MV, KURIAN N, QIN S, PAPADOPOULOU N, WESTERINK BH, CREMERS TI, EPPING-JORDAN MP, LE POUL E, RAY DE, FONE KC, KENDALL DA, MARSDEN CA and SHARP TV, 2013. Lentiviral Delivery of a Vesicular Glutamate Transporter 1 (VGLUT1)-Targeting Short Hairpin RNA Vector Into the Mouse Hippocampus Impairs Cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. (In Press.) WATSON, D.J.G., MARSDEN, C.A., MILLAN, M.J. and FONE, K.C.F., 2012. Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment International Journal of Neuropsychopharmacology. 15(4), 471-484