Mantovani, Giuseppe - University of Nottingham

个人简介

I gained my degree in Industrial Chemistry at the University of Bologna (Italy) in 1998. This included a 12 months research project in organic synthetic methodologies working at the sulphur-mediated total synthesis of enantiopure conduritols starting from reduced sugars, in Prof. V. Cere's group.In Nov 2002 I was awarded my PhD in Chemistry (Corso di Perfezionamento in Scienze degli Idrocarburi) from the Scuola Normale Superiore of Pisa (Italy) working on the design and synthesis of novel transition-metal catalysts based on iminopyridine ligands for the olygomerisation of ethylene to alpha-olefins (research sponsored by ENI spa) in Dr. C. Bianchini's group at the ICCOM-CNR institute in Florence.Shortly afterwards I joined the group of Prof. D. M. Haddleton at the University of Warwick as a post-doctoral research assistant. In the 2003-2005 period I held a Marie Curie Post-doctoral Fellowship awarded by the European Commission.In Warwick I've been involved in a number of different projects mainly focused on the use of controlled radical polymerisation techniques (mainly transition metal-mediated living radical polymerisation, TMM-LRP, often termed ATRP) for: Design and synthesis of novel protein biohybrid materials obtained by site-specific conjugation of precision alpha-functional polymers to appropriate (poly)peptides. Design and synthesis of well-defined functional glycopolymers and study of their ability of recognising specific protein receptors (lectins) Grafting of functional macromolecules to surfaces (glass, cellulose, crosslinked polystyrene beads) via "grafting to" and "grafting from" approaches. 4) Combination of Cu(I)-catalysed Living Radical Polymerisation (LRP) with other synthetic techniques (i.e. "click" chemistry). In Jan 2009 I was appointed Lecturer in Lecturer in Biologics Delivery in the School of Pharmacy at Nottingham.

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BANSAL, K. K., KAKDE, D., PURDIE, L., IRVINE, D. J., HOWDLE, S. M., MANTOVANI, G. and ALEXANDER, C., 2015. New biomaterials from renewable resources-amphiphilic block copolymers from δ-decalactone: Polymer Chemistry Polymer Chemistry. 6(40), 7196-7210 LOCZENSKI ROSE, VANESSA, SHUBBER, SAIF, SAJEESH, S, SPAIN, SEBASTIAN G, PURI, SANYOGITTA, ALLEN, STEPHANIE, LEE, DONG-KI and WINKLER, G. SEBASTIAAN, 2015. Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown Biomacromolecules. 16, 3480-3490 MATINI, TERESA, FRANCINI, NORA, BATTOCCHIO, ANNA, SPAIN, SEBASTIAN G., MANTOVANI, GIUSEPPE, VICENT, MARIA J., SANCHIS, JOAQUIN, GALLON, ELENA, MASTROTTO, FRANCESCA, SALMASO, STEFANO, CALICETI, PAOLO and ALEXANDER, CAMERON, 2014. Synthesis and characterization of variable conformation pH responsive block co-polymers for nucleic acid delivery and targeted cell. entry POLYMER CHEMISTRY. 5(5), 1626-1636 MASTROTTO, FRANCESCA, SALMASO, STEFANO, ALEXANDER, CAMERON, MANTOVANI, GIUSEPPE and CALICETI, PAOLO, 2013. Novel pH-responsive nanovectors for controlled release of ionisable drugs JOURNAL OF MATERIALS CHEMISTRY B. 1(39), 5335-5346 REDHEAD, M., MANTOVANI, G., NAWAZ, S., CARBONE, P., GORECKI, D.C., ALEXANDER, C. and BOSQUILLON, C., 2012. Relationship between the affinity of PEO-PPO-PEO block copolymers for biological membranes and their cellular effects Pharmaceutical Research. 29(7), 1908-1918 JONES, M.W., MANTOVANI, G., BLINDAUER, C.A., RYAN, S.M., WANG, X., BRAYDEN, D.J. and HADDLETON, D.M., 2012. Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts Journal of the American Chemical Society. 134(17), 7406-7413 NAWAZ, S., REDHEAD, M., MANTOVANI, G., ALEXANDER, C., BOSQUILLON, C. and CARBONE, P., 2012. Interactions of PEO-PPO-PEO block copolymers with lipid membranes: a computational and experimental study linking membrane lysis with polymer structure Soft Matter. 8(25), 6744-6754 JONES, M., GIBSON, M., MANTOVANI, G. and HADDLETON, D., 2011. Tunable thermo-responsive polymer-protein conjugates via a combination of nucleophilic thiol-ene "click" and SET-LRP POLYMER CHEMISTRY. VOL 2(NUMBER 3), 572-574 MASTROTTO, F., CALICETI, P., AMENDOLA, V., BERSANI, S., MAGNUSSON, J.P., MENEGHETTI, M., MANTOVANI, G., ALEXANDER, C. and SALMASO, S., 2011. Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting Chemical Communications. 47(35), 9846-9848 CASETTARI, L., VLLASALIU, D., MANTOVANI, G., HOWDLE, S.M., STOLNIK, S. and ILLUM, L., 2010. Effect of PEGylation on the toxicity and permeability enhancement of chitosan Biomacromolecules. 11(11), 2854-2865 RAWLINSON, LEE-ANNE B, RYAN, SINÉAD M, MANTOVANI, GIUSEPPE, SYRETT, JAY A, HADDLETON, DAVID M and BRAYDEN, DAVID J, 2010. Antibacterial effects of poly(2-(dimethylamino ethyl)methacrylate) against selected gram-positive and gram-negative bacteria. Biomacromolecules. 11(2), 443-53 SYRETT, J.A., MANTOVANI, G., BARTON, W.R.S., PRICE, D. and HADDLETON, D.M., 2010. Self-healing polymers prepared via living radical polymerisation Polymer Chemistry. 1(1), 102-106 JONES, MATHEW W, MANTOVANI, GIUSEPPE, RYAN, SINEAD M, WANG, XUEXUAN, BRAYDEN, DAVID J and HADDLETON, DAVID M, 2009. Phosphine-mediated one-pot thiol-ene "click" approach to polymer-protein conjugates. Chemical communications (Cambridge, England). 5272-4 SAYERS, C., MANTOVANI, G., RYAN, S., RANDEV, R., KEIPER, O., LESZCZYSZYN, O., BLINDAUER, C., BRAYDEN, D. and HADDLETON, D., 2009. Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation SOFT MATTER. VOL 5(NUMBER 16), 3038-3046 KEELY, S., RYAN, S.M., HADDLETON, D.M., LIMER, A., MANTOVANI, G., MURPHY, E.P., COLGAN, S.P. and BRAYDEN, D.J., 2009. Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers Journal of Controlled Release. 135(1), 35-43 RYAN, SINÉAD M, MANTOVANI, GIUSEPPE, WANG, XUEXUAN, HADDLETON, DAVID M and BRAYDEN, DAVID J, 2008. Advances in PEGylation of important biotech molecules: delivery aspects. Expert opinion on drug delivery. 5(4), 371-83 GENG, J., LINDQVIST, J., MANTOVANI, G. and HADDLETON, D.M., 2008. Simultaneous copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and living radical polymerization Angewandte Chemie International Edition. 47(22), 4180-4183 CHEN, GAOJIAN, WRIGHT, PETER M, GENG, JIN, MANTOVANI, GIUSEPPE and HADDLETON, DAVID M, 2008. Tunable thermoresponsive water-dispersed multiwalled carbon nanotubes. Chemical communications (Cambridge, England). 1097-9 WRIGHT, PM, MANTOVANI, G and HADDLETON, DM, 2008. Polymerization Of Methyl Acrylate Mediated By Copper(0)/Me-6-Tren In Hydrophobic Media Enhanced By Phenols; Single Electron Transfer-Living Radical Polymerization Journal Of Polymer Science Part A-Polymer Chemistry. 46(22), 7376-7385 LI, F, BERTONCELLO, P, CIANI, I, MANTOVANI, G and UNWIN, PR, 2008. Incorporation Of Functionalized Palladium Nanoparticles Within Ultrathin Nafion Films: A Nanostructured Composite For Electrolytic And Redox-Mediated Hydrogen Evolution Advanced Functional Materials. 18(11), 1685-1693 GENG, JIN, MANTOVANI, GIUSEPPE, TAO, LEI, NICOLAS, JULIEN, CHEN, GAOJIAN, WALLIS, RUSSELL, MITCHELL, DANIEL A, JOHNSON, BENJAMIN R G, EVANS, STEPHEN D and HADDLETON, DAVID M, 2007. Site-directed conjugation of "clicked" glycopolymers to form glycoprotein mimics: binding to mammalian lectin and induction of immunological function. Journal of the American Chemical Society. 129(49), 15156-63 TAO, LEI, GENG, JIN, CHEN, GAOJIAN, XU, YINGJIAN, LADMIRAL, VINCENT, MANTOVANI, GIUSEPPE and HADDLETON, DAVID M, 2007. Bioconjugation of biotinylated PAMAM dendrons to avidin. Chemical communications (Cambridge, England). 3441-3 LADMIRAL, VINCENT, MANTOVANI, GIUSEPPE, CLARKSON, GUY J, CAUET, SOLENE, IRWIN, JACOB L and HADDLETON, DAVID M, 2006. Synthesis of neoglycopolymers by a combination of "click chemistry" and living radical polymerization. Journal of the American Chemical Society. 128(14), 4823-30 TAO, LEI, CHEN, GAOJIAN, MANTOVANI, GIUSEPPE, YORK, STEVE and HADDLETON, DAVID M, 2006. Modification of multi-wall carbon nanotube surfaces with poly(amidoamine) dendrons: synthesis and metal templating. Chemical communications (Cambridge, England). 4949-51 NICOLAS, JULIEN, SAN MIGUEL, VERONICA, MANTOVANI, GIUSEPPE and HADDLETON, DAVID M, 2006. Fluorescently tagged polymer bioconjugates from protein derived macroinitiators. Chemical communications (Cambridge, England). 4697-9