Gershkovich, Pavel - University of Nottingham

个人简介

I have completed my BScPharm, MSc in Clinical Pharmacy and PhD in Pharmaceutical Sciences in The Hebrew University of Jerusalem, Israel. My graduate research focused on the mechanisms of intestinal lymphatic transport of lipophilic drugs (under the supervision of Prof. Amnon Hoffman). I had been a Postdoctoral Fellow in the Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada in the laboratory of Prof. Kishor M. Wasan for the period of May 2007 to August 2009. From September 2009 until April 2012 I was employed as Research Associate in the same Division. I was appointed to a position of Assistant Professor of Pharmacokinetics in the School of Pharmacy, University of Nottingham, in April 2012.

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TAHA DA, ZGAIR A, LEE JB, DE MOOR CH, BARRETT DA, BRUCE KD, SUNGELO M, ECKEL RH and GERSHKOVICH P, 2017. Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (In Press.) LEE JB, ZGAIR A, TAHA DA, ZANG X, KAGAN L, KIM TH, KIM MG, YUN HY, FISCHER PM and GERSHKOVICH P, 2017. Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. (In Press.) TAHA DA, DE MOOR CH, BARRETT DA, LEE JB, GANDHI RD, HOO CW, GERSHKOVICH P., 2016. The role of acid-base imbalance in statin-induced myotoxicity Translational Research. (In Press.) 2016. Proposing the Use of Partial AUC as an Adjunctive Measure in Establishing Bioequivalence Between Deltoid and Gluteal Administration of Long-Acting Injectable Antipsychotics. European journal of drug metabolism and pharmacokinetics. (In Press.) QAZZAZ ME, RAJA VJ, LIM KH, KAM TS, LEE JB, GERSHKOVICH P and BRADSHAW TD, 2016. In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer letters. 370(2), 185-97 2016. Linking In Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations. Molecular pharmaceutics. (In Press.) 2016. Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American journal of translational research. 8(8), 3448-3459 LEE JB, ZGAIR A, KIM TH, KIM MG, YOO SD, FISCHER PM and GERSHKOVICH P, 2016. Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1040, 73-80 GITTINGS S, TURNBULL N, HENRY B, ROBERTS CJ and GERSHKOVICH P, 2015. Characterisation of Human Saliva as a Platform for Oral Dissolution Medium Development. European Journal of Pharmaceutics and Biopharmaceutics. 91, 16-24 BENITO-GALLO P, FRANCESCHETTO A, WONG JCM, MARLOW M, ZANN V, SCHOLES P and GERSHKOVICH P, 2015. Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. (In Press.) ZGAIR A, WONG JCM, SABRI A, FISCHER PM, BARRETT DA, CONSTANTINESCU CS and GERSHKOVICH P, 2015. Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and Δ(9)-tetrahydrocannabinol in rat plasma. Journal of pharmaceutical and biomedical analysis. 114, 145-151 GITTINGS, SALLY, TURNBULL, NEIL, HENRY, BRIAN, ROBERTS, CLIVE J. and GERSHKOVICH, PAVEL, 2015. Characterisation of human saliva as a platform for oral dissolution medium development EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 91, 16-24 BENITO-GALLO, PALOMA, FRANCESCHETTO, ALESSANDRO, WONG, JONATHAN C. M., MARLOW, MARIA, ZANN, VANESSA, SCHOLES, PETER and GERSHKOVICH, PAVEL, 2015. Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 93, 353-362 GERSHKOVICH P, WASAN KM, RIBEYRE C, IBRAHIM F and MCNEILL JH, 2015. Effect of variations in treatment regimen and liver cirrhosis on exposure to benzodiazepines during treatment of alcohol withdrawal syndrome. Drugs in context. 4, 212287 TAHA, DHIAA A., WASAN, ELLEN K., WASAN, KISHOR M. and GERSHKOVICH, PAVEL, 2015. Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 18(4), 344-367 TAHA DA, WASAN EK, WASAN KM and GERSHKOVICH P, 2015. Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Socie?te? canadienne des sciences pharmaceutiques. 18(4), 344-67 KAGAN L, GERSHKOVICH P, WASAN KM and MAGER DE, 2014. Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition. Pharmaceutical research. GITTINGS S, TURNBULL N, ROBERTS CJ and GERSHKOVICH P, 2014. Dissolution methodology for taste masked oral dosage forms. Journal of controlled release : official journal of the Controlled Release Society. 173C, 32-42 TAHA DA, DE MOOR CH, BARRETT DA and GERSHKOVICH P, 2014. Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies. Translational research : the journal of laboratory and clinical medicine. 164(2), 85-109 SACHS-BARRABLE K, CONWAY J, GERSHKOVICH P, IBRAHIM F and WASAN KM, 2014. The use of the United States FDA programs as a strategy to advance the development of drug products for neglected tropical diseases. Drug development and industrial pharmacy. WASAN KM, SIVAK O, BARTLETT K, WASAN EK and GERSHKOVICH P, 2014. Novel oral amphotericin B formulation (iCo-010) remains highly effective against murine systemic candidiasis following exposure to tropical temperature. Drug development and industrial pharmacy. 1-6 IBRAHIM F, GERSHKOVICH P, SIVAK O, WASAN EK and WASAN KM, 2013. Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats. Drug development and industrial pharmacy. 39(9), 1277-83 GERSHKOVICH P, IBRAHIM F, SIVAK O, DARLINGTON JW and WASAN KM, 2013. A simple and sensitive method for determination of vitamins D(3) and K(1) in rat plasma: application for an in vivo pharmacokinetic study. Drug development and industrial pharmacy. IBRAHIM F, GERSHKOVICH P, SIVAK O, WASAN EK and WASAN KM, 2012. Assessment Of Novel Oral Lipid-Based Formulations Of Amphotericin B Using An In Vitro Lipolysis Model. European Journal Of Pharmaceutical Sciences : Official Journal Of The European Federation For Pharmaceutical Sciences. 46, 323-328 SAATCHI K, GELDER N, GERSHKOVICH P, SIVAK O, WASAN KM, KAINTHAN RK, BROOKS DE and H?FELI UO, 2012. Long-Circulating Non-Toxic Blood Pool Imaging Agent Based On Hyperbranched Polyglycerols. International Journal Of Pharmaceutics. 422(1-2), 418-27