Bosquillon, Cynthia - University of Nottingham

个人简介

I graduated as a pharmacist from the Université catholique de Louvain, Belgium in 1998 and then pursued post-graduate studies under the co-supervision of Profs. Rita Vanbever and Véronique Préat. I gained my PhD in September 2003 and in 2004, I moved to London to work on a post-doctoral project directed by Dr.Ben Forbes (King's College London) and Dr.Nicola Clear (Pfizer R&D). In 2005, I was awarded a University of London Maplethorpe fellowship, which gave me, in addition to a valuable teaching experience, the opportunity to develop my own research area and supervise both undergraduate and postgraduate research students at King's. I was appointed to a lectureship in Drug Delivery at Nottingham in 2007.

研究领域

My research interests have so far focussed on drug inhalation, of which I've explored different aspects, from the formulation and characterisation of dry powders for systemic delivery of therapeutic proteins to the developme

近期论文

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LUO T, MAGNUSSON J, PRÉAT V, FRÉDÉRICK R, ALEXANDER C, BOSQUILLON C and VANBEVER R, 2016. Synthesis and In Vitro Evaluation of Polyethylene Glycol-Paclitaxel Conjugates for Lung Cancer Therapy. Pharmaceutical research. 33(7), 1671-81 LUO T, LOIRA-PASTORIZA C, PATIL HP, UCAKAR B, MUCCIOLI GG, BOSQUILLON C and VANBEVER R, 2016. PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma. Journal of controlled release : official journal of the Controlled Release Society. 239, 62-71 2016. Drug transporters in the lung: Expression and potential impact on pulmonary drug disposition RSC Drug Discovery Series. 2016-January(54), 184-227 HUTTER V, CHAU DY, HILGENDORF C, BROWN A, COOPER A, ZANN V, PRITCHARD DI, BOSQUILLON C., CHAU DY,, HILGENDORF C,, BROWN A,, COOPER A,, ZANN V,, PRITCHARD DI, and BOSQUILLON C., 2014. Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1. European Journal of Pharmaceutics and Biopharmaceutics. 86(1), 74-82 MUKHERJEE, M., LATIF, M.L., PRITCHARD, D.I. and BOSQUILLON, C., 2013. In-cell Western™ detection of organic cation transporters in bronchial epithelial cell layers cultured at an air-liquid interface on Transwell® inserts. J Pharmacol Toxicol Methods. 68(2), 184-189 BAYARD, F.J.C., THIELEMANS, W., PRITCHARD, D.I., PAINE, S.W., YOUNG, S.S., BÄCKMAN, P., EWING, P. and BOSQUILLON, C., 2013. Polyethylene glycol-drug ester conjugates for prolonged retention of small inhaled drugs in the lung Journal of Controlled Release. 171(2), 234-240 STEWART, C.E., TORR, E.E., MOHD JAMILI, N.H., BOSQUILLON, C. and SAYERS, I., 2012. Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research Journal of Allergy. 2012, 943982 MUKHERJEE M, PRITCHARD DI and BOSQUILLON C, 2012. Evaluation Of Air-Interfaced Calu-3 Cell Layers For Investigation Of Inhaled Drug Interactions With Organic Cation Transporters In Vitro. International Journal Of Pharmaceutics. 426(1-2), 7-14 REDHEAD, M., MANTOVANI, G., NAWAZ, S., CARBONE, P., GORECKI, D.C., ALEXANDER, C. and BOSQUILLON, C., 2012. Relationship between the affinity of PEO-PPO-PEO block copolymers for biological membranes and their cellular effects Pharmaceutical Research. 29(7), 1908-1918 NAWAZ, S., REDHEAD, M., MANTOVANI, G., ALEXANDER, C., BOSQUILLON, C. and CARBONE, P., 2012. Interactions of PEO-PPO-PEO block copolymers with lipid membranes: a computational and experimental study linking membrane lysis with polymer structure Soft Matter. 8(25), 6744-6754 HUTTER V, HILGENDORF C, COOPER A, ZANN V, PRITCHARD DI and BOSQUILLON C, 2012. Evaluation of layers of the rat airway epithelial cell line rl-65 for permeability screening of inhaled drug candidates. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. 47(2), 481-9 IEONG, N.S., REDHEAD, M., BOSQUILLON, C., ALEXANDER, C., KELLAND, M. and O'REILLY, R.K., 2011. The missing lactam-thermoresponsive and biocompatible poly(N-vinylpiperidone) polymers by xanthate-mediated RAFT polymerization Macromolecules. 44(4), 886-893 RYMER, S.J., TENDLER, S.J.B., BOSQUILLON, C., WASHINGTON, C and ROBERTS, C.J.R., 2011. Self-assembling peptides and their potential applications in biomedicine Therapeutic Delivery. 2(8), 1043-1056 MUKHERJEE, M, PRITCHARD, DI and BOSQUILLON, C, 2011. Variations in the expression of Organic Cation Transporters (OCT) in bronchial epithelial cells following exposure to house dust components In: Annual Meeting of the British-Society-for-Allergy-and-Clinical-Immunology (BSACI). 1832-1832 AL GHANAMI, R.C., SAUNDERS, B.R., BOSQUILLON, C., SHAKESHEFF, K.M. and ALEXANDER, C., 2010. Responsive particulate dispersions for reversible binding and deconstruction of 3D cell environments Soft Matter. 6(20), 5037-5044 BOSQUILLON CYNTHIA, 2010. Assessing the Role of Transporters in the Disposition of Inhaled Drugs Using a Respiratory Epithelial Cell Culture Model Proceedings of the Respiratory Drug Delivery Conference. 1, 83-90 BOSQUILLON, CYNTHIA, 2010. Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs? Journal of pharmaceutical sciences. 99(5), 2240-55 DOS SANTOS, MA, BOSQUILLON, C, RUSSOMANO, T, SUNDARESAN, A, FALCAO, F, MARRIOTT, C and FORBES, B, 2010. Modelling The Effects Of Microgravity On The Permeability Of Air Interface Respiratory Epithelial Cell Layers Advances In Space Research. 46(6), 712-718