Winkler, Sebastiaan - University of Nottingham

个人简介

Sebastiaan gained his PhD from Erasmus Medical Centre (The Netherlands), where he studied the molecular mechanisms of DNA repair disorders using a biochemical approach. He then did his postdoctoral training in the Cancer Research London Research Institute at Clare Hall laboratories, which was supported by an EMBO Long Term Fellowship. After taking up a position at the University Medical Centre Utrecht (The Netherlands), he joined the School of Pharmacy in 2007, where he established an independent research programme concentrating on eukaryotic gene regulation.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

FARAJI F, HU Y, YANG HH, LEE MP, WINKLER GS, HAFNER M and HUNTER KW, 2016. Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7. PLoS genetics. 12(1), e1005820 HAGE N, RENSHAW JG, WINKLER GS, GELLERT P, STOLNIK S and FALCONE FH, 2015. Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag. Protein expression and purification. 106, 25-30 NAIM HAGE, TINA HOWARD, CHRIS PHILLIPS, CLAIRE BRASSINGTON, ROSS OVERMAN, JUDIT DEBRECZENI, PAUL GELLERT, SNOW STOLNIK, G SEBASTIAAN WINKLER and F FALCONE, 2015. Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA Science Advances. 1(e1500315), LOCZENSKI ROSE, VANESSA, SHUBBER, SAIF, SAJEESH, S, SPAIN, SEBASTIAN G, PURI, SANYOGITTA, ALLEN, STEPHANIE, LEE, DONG-KI, WINKLER, G SEBASTIAAN and MANTOVANI, GIUSEPPE, 2015. Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown. Biomacromolecules. 16(11), 3480-90 MARYATI M, AIRHIHEN B and WINKLER GS, 2015. The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module. The Biochemical journal. 469(1), 169-76 JADHAV GP, KAUR I, MARYATI M, AIRHIHEN B, FISCHER PM and WINKLER GS, 2015. Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorganic & medicinal chemistry letters. 25(19), 4219-24 CANO F, RAPITEANU R, SEBASTIAAN WINKLER G and LEHNER PJ, 2015. A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. Nature communications. 6, 8670 COLLINS HM, ABDELGHANY MK, MESSMER M, YUE B, DEEVES SE, KINDLE KB, MANTELINGU K, ASLAM A, WINKLER GS, KUNDU TK and HEERY DM, 2013. Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells. BMC cancer. 13(1), 37 WAHLE E and WINKLER GS, 2013. RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes. Biochimica et biophysica acta. 1829(6-7), 561-70 MARYATI, M., KAUR, I., JADHAV,G.P., OLOTU-UMOREN, L., OVEH, B., HASHMI, L., FISCHER, P.M. and WINKLER, G.S., 2013. A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity Nucleic Acids Research. n/a(n/a), n/a MARYATI M, KAUR I, JADHAV GP, OLOTU-UMOREN L, OVEH B, HASHMI L, FISCHER PM and WINKLER GS, 2013. A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity. Nucleic acids research. (In Press.) WINKLER GS and BALACCO DL, 2013. Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex. Frontiers in genetics. 4, 296 DOIDGE, RACHEL, MITTAL, SALONI, ASLAM, AKHMED and WINKLER, G. SEBASTIAAN, 2012. Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex BIOCHEMICAL SOCIETY TRANSACTIONS. 40, 896-901 DOIDGE, R., MITTAL, S., ASLAM, A. and WINKLER, G.S., 2012. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-Not complex PLOS ONE. 7(12), e51331 DOIDGE R, MITTAL S, ASLAM A and WINKLER GS, 2012. Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex. Biochemical Society transactions. 40(4), 896-901 MITTAL, S., ASLAM, A., DOIDGE, R., MEDICA, R. and WINKLER, G.S., 2011. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence Molecular Biology of the Cell. 22(6), 748-758 WINKLER, G.S., 2010. The mammalian anti-proliferative BTG/Tob protein family. Journal of cellular physiology. 222(1), 66-72 ASLAM, A., MITTAL, S., KOCH, F., ANDRAU, J.-C. and WINKLER, G.S., 2009. The Ccr4-Not deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation Molecular Biology of the Cell. 20(17), 3840-3850 HUANG, A., DE JONG, R.N., WIENK, H., WINKLER, G.S., TIMMERS, H.T.M. and BOELENS, R., 2009. E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity Journal of Molecular Biology. 385(2), 507-519 MULDER, KLAAS W, INAGAKI, AKIKO, CAMERONI, ELISABETTA, MOUSSON, FLORENCE, WINKLER, G SEBASTIAAN, DE VIRGILIO, CLAUDIO, COLLART, MARTINE A and TIMMERS, H TH MARC, 2007. Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae. Genetics. 176(1), 181-92 WINKLER, G.S.., MULDER, K.W., BARDWELL, V.J., KALKHOVEN, E. and TIMMERS, H.T.M., 2006. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription The EMBO journal. 25(13), 3089-3099 DREIJERINK, KOEN M A, MULDER, KLAAS W, WINKLER, G SEBASTIAAN, HÖPPENER, JO W M, LIPS, CORNELIS J M and TIMMERS, H TH MARC, 2006. Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer research. 66(9), 4929-35