Stocks, Michael - University of Nottingham

个人简介

In April 2012, I made the transition into academia and was appointed as Associate Professor in Medicinal Chemistry in the Division of Medicinal Chemistry and Structural Biology.

研究领域

My research interests are focused on early stage drug discovery designing and synthesising new chemical scaffolds to interact with biological targets generating both high-quality tool compounds and lead-like compounds to probe biological targets and provide the starting points for successful drug discovery programs. Utilising synthetic and physical chemistry to address and overcome drug discovery issues such as; hit and lead optimisation, absorption, metabolism and compound selectivity. Conformational analysis and structure-based drug design. Fragment based drug design - designing and optimising high-quality fragments and libraries. Combining synergistic pharmacology's within a single small molecule.

近期论文

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SCHWEHM, CAROLIN, KELLAM, BARRIE, GARCES, AIMIE E., HILL, STEPHEN J., KINDON, NICHOLAS D., BRADSHAW, TRACEY D., LI, JIN, MACDONALD, SIMON J. F., ROWEDDER, JAMES E., STODDART, LEIGH A. and STOCKS, MICHAEL J., 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase $delta$ (PI3K$delta$) Inhib Journal of Medicinal Chemistry. acs.jmedchem.6b01801 MICHAEL J. STOCKS, SEAN CONROY and BARRIE KELLAM, 2016. Drug-like antagonists of P2Y receptors - from lead identification to drug development Journal of Medicinal Chemistry. MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. Linifanib - a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator CHEMICAL COMMUNICATIONS. 51(29), 6384-6387 SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold: ACS Medicinal Chemistry Letters ACS Medicinal Chemistry Letters. 6, 324-328 STOCKS, MICHAEL, 2015. Structure-Based Design of Drugs and Other Bioactive Molecules . Edited by Arun K. Ghosh and Sandra Gemma: ChemMedChem ChemMedChem. 10, 926-928 STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F.G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery: Bioorganic & Medicinal Chemistry Bioorganic & Medicinal Chemistry. 23, 6891-6899 MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator: Chem. Commun. Chem. Commun.. 51, 6384-6387 MICHAEL J STOCKS, LILIAN ALCARAZ, ANDREW BAILEY, ROGER BONNERT, ELAINE CADOGAN, JADEEN CHRISTIE, JOHN DIXON, STEPHEN CONNOLLY, ANTHONY COOK, STUART PAINE, 2014. Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action ACS Med Chem Lett. BRIOCHE, JULIEN, COURANT, THIBAUT, ALCARAZ, LILIAN, STOCKS, MICHAEL, FURBER, MARK, ZHU, JIEPING and MASSON, GÉRALDINE, 2014. Chiral Phosphoric Acid-Catalyzed Enantioselective Three- Component Aza-Diels-Alder Reactions of Aminopyrroles and Aminopyrazoles: Advanced Synthesis & Catalysis Advanced Synthesis & Catalysis. 356, 1719-1724 SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J., KELLAM, BARRIE and STOCKS, MICHAEL J., 2014. Preparation and structural analysis of (±)- cis -ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)- trans -ethyl 2-oxooctahydro-1 H -pyrrolo[3,2- c ]pyridine-5-carboxylate: Acta Crystallographica Section C Structural Chemistry Acta Crystallographica Section C Structural Chemistry. 70, 1161-1168 STOCKS, MICHAEL J, ALCARAZ, LILIAN, BAILEY, ANDREW, BONNERT, ROGER, CADOGAN, ELAINE, CHRISTIE, JADEEN, DIXON, JOHN, CONNOLLY, STEPHEN, COOK, ANTHONY, FISHER, ADRIAN, FLAHERTY, ALICE, HUMPHRIES, ALEXANDER, INGALL, ANTHONY, JORDAN, STEPHEN, LAWSON, MANDY, MULLEN, ALEX, NICHOLLS, DAVID, PAINE, STUART, PAIRAUDEAU, GARRY and YOUNG, ALAN, 2014. Discovery of AZD3199, An Inhaled Ultralong Acting β 2 Receptor Agonist with Rapid Onset of Action: ACS Med. Chem. Lett. ACS Med. Chem. Lett.. 5, 416-421 ALCARAZ, L., BAILEY, A., CADOGAN, E., CONNOLLY, S., JEWELL, R., JORDAN, S., KINDON, N., LISTER, A., LAWSON, M., MULLEN, A., DAINTY, I., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J., THORNE, P. and YOUNG, A., 2012. From libraries to candidate: the discovery of new ultra long-acting dibasic β2-adrenoceptor agonists Bioorganic & Medicinal Chemistry Letters. 22(1), 689-95 SU Y, BOUMA MJ, ALCARAZ L, STOCKS M, FURBER M, MASSON G and ZHU J, 2012. Organocatalytic enantioselective one-pot four-component ugi-type multicomponent reaction for the synthesis of epoxy-tetrahydropyrrolo[3,4-b]pyridin-5-ones. Chemistry (weinheim an der bergstrasse, germany). 18(40), 12624-7 CONNOLLY, S., ALCARAZ, L., BAILEY, A., CADOGAN, E., CHRISTIE, J., COOK, A.R., FISHER, A.J., HILL, S., HUMPHRIES, A., INGALL, A.H., KANE, Z., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J. and YOUNG, A., 2011. Design-driven LO: the discovery of new ultra long acting dibasic β2-adrenoceptor agonists Bioorganic & Medicinal Chemistry Letters. 21(15), 4612-4616 STOCKS, M.J., ALCARAZ, L., BAILEY, A., BONNERT, R., CADOGAN, E., CHRISTIE, J., CONNOLLY, S., COOK, A., FISHER, A., FLAHERTY, A., HILL, S., HUMPHRIES, A., INGALL, A., JORDAN, S., LAWSON, M., MULLEN, A., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., ST-GALLAY, S. and YOUNG, A., 2011. Design driven HtL: the discovery and synthesis of new high efficacy β2-agonists Bioorganic & Medicinal Chemistry Letters. 21(13), 4027-4031 EDMAN, K, FURBER, M, HEMSLEY, P, JOHANSSON, C, PAIRAUDEAU, G, PETERSEN, J, STOCKS, M, TERVO, A, WARD, A, WELLS, E and WISSLER, L, 2011. The discovery of mmp7 inhibitors exploiting a novel selectivity trigger Chemmedchem. 6(5), 769-773 ROBERTS, B, LIPTROT, D, LUKER, T, STOCKS, MJ, BARBER, C, WEBB, N, DODS, R and MARTIN, B, 2011. Molybdenum-mediated synthesis of quinazolin-4(3h)-ones via cyclocarbonylation using microwave irradiation Tetrahedron Letters. 52(29), 3793-3796 ROBERTS, BRYAN, LIPTROT, DAVID, LUKER, TIM, STOCKS, MICHAEL J, BARBER, CATHERINE, WEBB, NICOLA, DODS, ROBERT and MARTIN, BARRIE, 2011. ChemInform Abstract: Molybdenum-Mediated Synthesis of Quinazolin-4(3H)-ones via Cyclocarbonylation Using Microwave Irradiation: ChemInform ChemInform. 42, no-no ROBERTS B, LIPTROT D, ALCARAZ L, LUKER T and STOCKS MJ, 2010. Molybdenum-mediated carbonylation of aryl halides with nucleophiles using microwave irradiation. Organic letters. 12(19), 4280-3 STOCKS, MJ, ALCARAZ, L, BAILEY, A, BOWERS, K, DONALD, D, EDWARDS, H, HUNT, F, KINDON, N, PAIRAUDEAU, G, THEAKER, J and WARNER, DJ, 2010. The discovery of new spirocyclic muscarinic m-3 antagonists Bioorganic & Medicinal Chemistry Letters. 20(24), 7458-7461 JOHNSON, TIM, CHESHIRE, DAVID R, STOCKS, MICHAEL J and THURSTON, VICKY T, 2010. ChemInform Abstract: A Carbonyl Ylide Approach to Substituted Furans: ChemInform ChemInform. 32, no-no STOCKS MJ, WILDEN GRH, PAIRAUDEAU G, PERRY MWD, STEELE J and STONEHOUSE JP, 2009. A practical method for targeted library design balancing lead-like properties with diversity. Chemmedchem. 4(5), 800-8 SMITH, NM, GREAVES, MJ, JEWELL, R, PERRY, MWD, STOCKS, MJ and STONEHOUSE, JP, 2009. One-pot, three-component copper-catalysed 'click' triazole synthesis utilising the inexpensive, shelf-stable diazotransfer reagent imidazole-1-sulfonyl azide hydrochloride Synlett. 1391-1394 GUILE, SD, ALCARAZ, L, BIRKINSHAW, TN, BOWERS, KC, EBDEN, MR, FURBER, M and STOCKS, MJ, 2009. Antagonists of the p2x(7) receptor. From lead identification to drug development Journal of Medicinal Chemistry. 52, 3123-3141 STONEHOUSE, JP, CHEKMAREV, DS, IVANOVA, NV, LANG, S, PAIRAUDEAU, G, SMITH, N, STOCKS, MJ, SVIRIDOV, SI and UTKINA, LM, 2008. One-pot four-component reaction for the generation of pyrazoles and pyrimidines Synlett. 100-104