Spriggs, Keith - University of Nottingham

个人简介

PhD Structure and evolution of the vertebrate transcription elongation factor TFIIS, with Dr Garry Morgan, University of Nottingham. 2001-2004 Postdoctoral Research Associate: Department of Biochemistry, University of Leicester, with Professor Anne Willis. Funded by BBSRC. Project aims were to investigate some of the mechanisms behind internal ribosome entry. 2004-2006 Postdoctoral Research Associate, University of Nottingham, UK & University of California, Davis, USA. Funded by the Wellcome Trust. 2006-2012 Lecturer in Gene Regulation, School of Pharmacy, University of Nottingham. 2012-present Associate Professor in Gene Regulation, School of Pharmacy, University of Nottingham

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WEBB TE, HUGHES A, SMALLEY DS and SPRIGGS KA, 2015. An internal ribosome entry site in the 5' untranslated region of epidermal growth factor receptor allows hypoxic expression. Oncogenesis. 4, e134 MODELSKA A, TURRO E, RUSSELL R, BEATON J, SBARRATO T, SPRIGGS K, MILLER J, GRÄF S, PROVENZANO E, BLOWS F, PHAROAH P, CALDAS C and LE QUESNE J, 2015. The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape. Cell death & disease. 6, e1603 WADELIN FR, FULTON J, COLLINS HM, TERTIPIS N, BOTTLEY A, SPRIGGS KA, FALCONE FH and HEERY DM, 2013. PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs. PloS one. 8(2), e58052 LE QUESNE, JOHN P C, SPRIGGS, KEITH A, BUSHELL, MARTIN and WILLIS, ANNE E, 2010. Dysregulation of protein synthesis and disease. The Journal of pathology. 220(2), 140-51 COBBOLD, L C, WILSON, L A, SAWICKA, K, KING, H A, KONDRASHOV, A V, SPRIGGS, K A, BUSHELL, M and WILLIS, A E, 2010. Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1. Oncogene. 29(19), 2884-91 BOTTLEY, A., PHILLIPS, N.M., WEBB, T.E., WILLIS, A.E. and SPRIGGS, K.A., 2010. eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease PLOS ONE. 5(9), e13030 SPRIGGS, KEITH A, BUSHELL, MARTIN and WILLIS, ANNE E, 2010. Translational regulation of gene expression during conditions of cell stress. Molecular cell. 40(2), 228-37 WADELIN, F., FULTON, J., MCEWAN, P.A., SPRIGGS, K.A., EMSLEY, J. and HEERY, D.M., 2010. Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia Molecular Cancer. 27(9), 226 POWLEY, I.R., KONDRASHOV, A., YOUNG, L.A., DOBBYN, H.C., HILL, K., CANNELL, I.G., STONELEY, M., KONG, Y.-W., COTES, J.A., SMITH, G.C.M., WEK, R., HAYES, C., GANT, T.W., SPRIGGS, K.A., BUSHELL, M. and WILLIS, A.E., 2009. Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes Genes & Development. 23(10), 1207-1220 SPRIGGS, K.A., COBBOLD, L.C., RIDLEY, S.H., COLDWELL, M., BOTTLEY, A., BUSHELL, M., WILLIS, ANNE E and SIDDLE, K., 2009. The human insulin receptor mRNA contains a functional internal ribosome entry segment Nucleic Acids Research. 37(17), 5881-5893 SPRIGGS, K.A., COBBOLD, L.C, JOPLING, C.L., COOPER, R.E., WILSON, L.A., STONELEY, M., COLDWELL, M.J., PONCET, D., SHEN, Y.C., MORLEY, S.J., BUSHELL, M. and WILLIS, A.E., 2009. Canonical initiation factor requirements of the myc family of internal ribosome entry segments Molecular and Cell Biology. 29(6), 1565-1574 KONG, Y.W., CANNELL, I.G., DE MOOR, C.H., HILL, K., GARSIDE, P.G., HAMILTON, T.L., MEIJER, H.A., DOBBYN, H.C., STONELEY, M., SPRIGGS, K.A., WILLIS, A.E. and BUSHELL, M., 2008. The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene Proceedings of the National Academy of Sciences of the United States of America. 105(26), 8866-8871 DOBBYN, H.C., HILL, K., HAMILTON, T.L., SPRIGGS, K.A., PICKERING, B.M., COLDWELL, J., DE MOOR, C.H., BUSHELL, M. and WILLIS, A.E., 2008. Regulation of BAG-1 IRES-mediated translation following chemotoxic stress Oncogene. 27, 1167-1174 COBBOLD, LAURA C, SPRIGGS, KEITH A, HAINES, STEPHEN J, DOBBYN, HELEN C, HAYES, CHRISTOPHER, DE MOOR, CORNELIA H, LILLEY, KATHRYN S, BUSHELL, MARTIN and WILLIS, ANNE E, 2008. Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Molecular and cellular biology. 28(1), 40-9 SPRIGGS, KEITH A, STONELEY, MARK, BUSHELL, MARTIN and WILLIS, ANNE E, 2008. Re-programming of translation following cell stress allows IRES-mediated translation to predominate. Biology of the cell / under the auspices of the European Cell Biology Organization. 100(1), 27-38 SAWICKA, KIRSTY, BUSHELL, MARTIN, SPRIGGS, KEITH A and WILLIS, ANNE E, 2008. Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein. Biochemical Society Transactions. 36(Pt 4), 641-7 BUSHELL, MARTIN, STONELEY, MARK, SPRIGGS, KEITH A and WILLIS, ANNE E, 2008. SF2/ASF TORCs up translation. Molecular cell. 30(3), 262-3 BUSHELL, M., STONELEY, M., KONG, Y.W., HAMILTON, T.L., SPRIGGS, K.A., DOBBYN, H.C., QIN, X., SARNOW, P. and WILLIS, A.E., 2006. Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis Molecular Cell. 23(3), 401-412 HAMILTON, T L, STONELEY, M, SPRIGGS, K A and BUSHELL, M, 2006. TOPs and their regulation. Biochemical Society Transactions. 34(Pt 1), 12-6 MITCHELL, S.A., SPRIGGS, K.A., BUSHELL, M., EVANS, J.R., STONELEY, M., LE QUESNE, J.P.C., SPRIGGS, R.V. and WILLIS, A.E., 2005. Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Genes & Development. 19(13), 1556-1571 SPRIGGS, K A, BUSHELL, M, MITCHELL, S A and WILLIS, A E, 2005. Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-acting factors. Cell Death and Differentiation. 12(6), 585-91 SPRIGGS, K A, MITCHELL, S A and WILLIS, A E, 2005. Investigation of interactions of polypyrimidine tract-binding protein with artificial internal ribosome entry segments. Biochemical Society Transactions. 33(Pt 6), 1483-6 JOPLING, C.L., SPRIGGS, K.A., MITCHELL, S.A., STONELEY, M. and WILLIS, A.E., 2004. L-Myc protein synthesis is initiated by internal ribosome entry RNA. 10(2), 287-298