Laughton, Charles - University of Nottingham

个人简介

My first degree was in Chemistry, and I then stayed on at Oxford to study for my DPhil with George Fleet on the total synthesis of analogues of the antimycoplasmic agent pseudomonic acid. I then moved to the CRC Experimental Cancer Chemotherapy Research Group at Aston University, working with Andy Gescher, John Hickman and Malcolm Stevens on protein kinase C inhibitors as antitumour agents. This awakened an interest in both cancer chemotherapy and computational chemistry. I next moved to the CRC Biomolecular Structure Unit at the Institute of Cancer Research, where with Stephen Neidle I was able to pursue molecular modeling full time, and also developed a particular interest in nucleic acid structure and recognition. In 1995 I took up a lectureship in the School of Pharmacy at Nottingham, and was promoted to Reader in 2001.

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IVANI, IVAN, DANS, PABLO D., NOY, AGNES, PEREZ, ALBERTO, FAUSTINO, IGNACIO, HOSPITAL, ADAM, WALTHER, JUERGEN, ANDRIO, PAU, GONI, RAMON, BALACEANU, ALEXANDRA, PORTELLA, GUILLEM, BATTISTINI, FEDERICA, LLUIS GELPI, JOSEP, GONZALEZ, CARLOS, VENDRUSCOLO, MICHELE, LAUGHTON, CHARLES A., HARRIS, SARAH A., CASE, DAVID A. and OROZCO, MODESTO, 2016. Parmbsc1: a refined force field for DNA simulations Nature Methods. 13(1), 55-+ LU, TIANGONG, LAUGHTON, CHARLES A., WANG, SHUDONG and BRADSHAW, TRACEY D., 2015. In Vitro Antitumor Mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide Molecular Pharmacology. 87(1), 18-30 MACKENZIE, R., BOOTH, J., ALEXANDER, C., GARNETT, M. C. and LAUGHTON, C. A., 2015. Multiscale Modeling of Drug-Polymer Nanoparticle Assembly Identifies Parameters Influencing Drug Encapsulation Efficiency Journal of Chemical Theory and Computation. 11(6), 2705-2713 MAZANETZ, MICHAEL P., LAUGHTON, CHARLES A. and FISCHER, PETER M., 2014. Investigation of the Flexibility of Protein Kinases Implicated in the Pathology of Alzheimer's Disease MOLECULES. 19(7), 9134-9159 HONG, WEI, LI, JINGYANG, LAUGHTON, CHARLES A., YAP, LEE FAH, PATERSON, IAN C. and WANG, HAO, 2014. Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling Journal of Molecular Graphics & Modelling. 51, 193-202 RANNOU, O., LECHATELIER, E., LARSON, M., NOURI, H., DALMAIS, B., LAUGHTON, C., JANNIERE, L. and SOULTANAS, P., 2013. Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis Nucleic Acids Research. 41(10), 5303-5320 GARTON M and LAUGHTON C, 2013. A Comprehensive Model for the Recognition of Human Telomeres by TRF1. Journal of molecular biology. 425(16), 2910-21 VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & biomolecular chemistry. 11(34), 5673-82 NG HW, LAUGHTON CA and DOUGHTY SW, 2013. Molecular dynamics simulations of the adenosine A2a receptor: structural stability, sampling, and convergence. Journal of chemical information and modeling. 53(5), 1168-78 WANG H, CUI J, HONG W, PATERSON IC and LAUGHTON CA, 2013. The study of interactions between DNA and PcrA DNA helicase by using targeted molecular dynamic simulations. Journal of molecular modeling. 19(11), 4997-5006 HIRT, B.V., WATTIS, J.A.D., PRESTON, S.P. and LAUGHTON, C.A., 2012. The effects of a telomere destabilizing agent on cancer cell-cycle dynamics: integrated modelling and experiments Journal of Theoretical Biology. 295, 9–22 CHAUDHURI, RIMA, CARRILLO, OLIVER, LAUGHTON, CHARLES ANTHONY and OROZCO, MODESTO, 2012. Application of Drug-Perturbed Essential Dynamics/Molecular Dynamics (ED/MD) to Virtual Screening and Rational Drug Design JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 8(7), 2204-2214 ZHANG J, STEVENS M.F.G, HUMMERSONE M, MADHUSUDAN S, LAUGHTON C.A and BRADSHAW T.D., 2011. Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair Oncology. In Press, (In Press.) HALL, GARETH, BRADSHAW, TRACEY D, LAUGHTON, CHARLES A, STEVENS, MALCOLM F and EMSLEY, JONAS, 2011. Structure of Mycobacterium tuberculosis thioredoxin in complex with quinol inhibitor PMX464. Protein science : a publication of the Protein Society. 20(1), 210-5 JOHNSON, LUCY A, BYRNE, HELEN M, WILLIS, ANNE E and LAUGHTON, CHARLES A, 2011. An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4. Integrative biology : quantitative biosciences from nano to macro. MITCHELL, J S, LAUGHTON, C A and HARRIS, SARAH A, 2011. Atomistic simulations reveal bubbles, kinks and wrinkles in supercoiled DNA. Nucleic acids research. 39(9), 3928-38 MOHAMMED, M.Z., VYJAYANTI, V.N., LAUGHTON, C.A., DEKKER, L.V., FISCHER, P.M., WILSON, D.M., ABBOTTS, R., SHAH, S., PATEL, P.M., HICKSON, I.D. and MADHUSUDAN, S., 2011. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines British Journal of Cancer. 104(4), 653-663 DUDUIALĂ, C.-I., WATTIS, J.A.D. and LAUGHTON, C.A., 2011. Self-organised criticality in base-pair breathing in DNA with a defect Physica D: Nonlinear Phenomena. 240(16), 1254-1261 ZHANG, JIHONG, STEVENS, MALCOLM F G, LAUGHTON, CHARLES A, MADHUSUDAN, SRINIVASAN and BRADSHAW, TRACEY D, 2010. Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications. Oncology. 78(2), 103-14