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研究领域

Research interests are in drug delivery, mainly using polymer based delivery systems for site specific delivery, e.g. nanoparticles micelles and soluble polymer systems. This encompasses delivery systems for proteins, oligonucleotides and DNA in addition to more conventional drug molecules, and the use of biological effectors e.g.ligands and antibodies.

近期论文

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TARESCO, V., CREASEY, R. G., KENNON, J., MANTOVANI, G., ALEXANDER, C., BURLEY, J. C. and GARNETT, M. C., 2016. Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis POLYMER. 89, 41-49 MENG, WEINA, GARNETT, MARTIN C., WALKER, DAVID A. and PARKER, TERENCE L., 2016. Penetration and intracellular uptake of poly(glycerol-adipate) nanoparticles into three-dimensional brain tumour cell culture models EXPERIMENTAL BIOLOGY AND MEDICINE. 241(5), 466-477 LUOGA W, MANSUR F, BUTTLE DJ, DUCE IR, GARNETT MC, LOWE A and BEHNKE JM, 2015. The relative anthelmintic efficacy of plant-derived cysteine proteinases on intestinal nematodes Journal of Helminthology. 89, 165-174 MACKENZIE, R., BOOTH, J., ALEXANDER, C., GARNETT, M. C. and LAUGHTON, C. A., 2015. Multiscale Modeling of Drug-Polymer Nanoparticle Assembly Identifies Parameters Influencing Drug Encapsulation Efficiency JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 11(6), 2705-2713 IVANOV, DELYAN P., PARKER, TERRY L., WALKER, DAVID A., ALEXANDER, CAMERON, ASHFORD, MARIANNE B., GELLERT, PAUL R. and GARNETT, MARTIN C., 2015. In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment JOURNAL OF BIOTECHNOLOGY. 205, 3-13 VLLASALIU, DRITON, FALCONE, FRANCO H., STOLNIK, SNJEZANA and GARNETT, MARTIN, 2014. Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules EXPERIMENTAL CELL RESEARCH. 323(1), 218-231 MUDIE, DEANNA M., MURRAY, KATHRYN, HOAD, CAROLINE L., PRITCHARD, SUSAN E., GARNETT, MARTIN C., AMIDON, GORDON L., GOWLAND, PENNY A., SPILLER, ROBIN C., AMIDON, GREGORY E. and MARCIANI, LUCA, 2014. Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State MOLECULAR PHARMACEUTICS. 11(9), 3039-3047 IVANOV DP, PARKER TL, WALKER DA, ALEXANDER C, ASHFORD MB, GELLERT PR and GARNETT MC, 2014. Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres. PloS one. 9(8), e103817 ABULATEEFEH, S.R., SPAIN, S.G., THURECHT, K.J., AYLOTT, J.W., CHAN, W.C., GARNETT, M.C. and ALEXANDER, C., 2013. Enhanced uptake of nanoparticle drug carriers via a thermoresponsive shell enhances cytotoxicity in a cancer cell line Biomaterials Science. 1(4), 434-442 FOWLER, R., VLLASALIU, D., TRILLO, F.F., GARNETT, M., ALEXANDER, C., HORSLEY, H., SMITH, B., WHITCOMBE, I., EATON, M. and STOLNIK, S., 2013. Nanoparticle transport in epithelial cells: pathway switching through bioconjugation Small. 9(19), 3282-3294 FOWLER R, VLLASALIU D, FALCONE FH, GARNETT M, SMITH B, HORSLEY H, ALEXANDER C and STOLNIK S, 2013. Uptake and transport of B12-conjugated nanoparticles in airway epithelium. Journal of controlled release : official journal of the Controlled Release Society. 172(1), 374-381 VLLASALIU, DRITON, SHUBBER, SAIF, FOWLER, ROBYN, GARNETT, MARTIN, ALEXANDER, CAMERON and STOLNIK, SNOW, 2013. Epithelial toxicity of alkylglycoside surfactants JOURNAL OF PHARMACEUTICAL SCIENCES. 102(1), 114-125 LUOGA, W, MANSUR, F, BUTTLE, D J, DUCE, I R, GARNETT, M C and BEHNKE, J M, 2012. The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment. Journal of helminthology. 86, 311-316 VLLASALIU D, SHUBBER S, GARNETT M, ALEXANDER C, EATON M and STOLNIK S, 2012. Evaluation Of Calcium Depletion As A Strategy For Enhancement Of Mucosal Absorption Of Macromolecules. Biochemical And Biophysical Research Communications. 418(1), 128-33 MORADI, E., VLLASALIU, D., GARNETT, M., FALCONE, F. and STOLNIK, S., 2012. Ligand density and clustering effects on endocytosis of folate modified nanoparticles RSC Advances. 2(7), 3025-3033 BUTTLE, D.J., BEHNKE, J.M., BARTLEY, Y., ELSHEIKHA, H.M., BARTLEY, D.J., GARNETT, M.C., DONNAN, A.A., JACKSON, F., LOWE, A. and DUCE, I.R., 2011. Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus Parasites and Vectors. 4(15 March 2011), 36 ABULATEEFEH, SAMER R., SPAIN, SEBASTIAN G., AYLOTT, JONATHAN W., CHAN, WENG C., GARNETT, MARTIN C. and ALEXANDER, CAMERON, 2011. Thermoresponsive polymer colloids for drug delivery and cancer therapy Macromolecular Bioscience. 11(12), 1722-1734 VLLASALIU D, FOWLER R, GARNETT M, EATON M and STOLNIK S, 2011. Barrier Characteristics Of Epithelial Cultures Modelling The Airway And Intestinal Mucosa: A Comparison. Biochemical And Biophysical Research Communications. 415(4), 579-85 CONROY, S., GARNETT, M., VLOEBERGHS, M., GRUNDY, R., CRAVEN, I. and WALKER, D., 2010. Medulloblastoma in childhood: revisiting intrathecal therapy in infants and children Cancer Chemotherapy and Pharmacology. 65(6), 1173-1189 VLLASALIU, DRITON, EXPOSITO-HARRIS, RUTH, HERAS, ANGELES, CASETTARI, LUCA, GARNETT, MARTIN, ILLUM, LISBETH and STOLNIK, SNOW, 2010. Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. International journal of pharmaceutics. 400(1-2), 183-93 ABULATEEFEH, S.R., SAEED, A.O., AYLOTT, J.W., CHAN, W.C., GARNETT, M.C., SAUNDERS, B.R. and ALEXANDER, C., 2009. Facile synthesis of responsive nanoparticles with reversible, tuneable and rapid thermal transitions from biocompatible constituents Chemical Communications. 2009(40), 6068-6070 GARNETT, M.C., FERRUTI, P., RANUCCI, E., SUARDI, M.A., HEYDE, M. and SLEAT, R., 2009. Sterically stabilized self-assembling reversibly cross-linked polyelectrolyte complexes with nucleic acids for environmental and medical applications Biochemical Society Transactions. 37(4), 713-716 HOWDEN, L., GIDDINGS, D., POWER, H., AROUSSI, A., VLOEBERGHS, M., GARNETT, M. and WALKER, D., 2008. Three-dimensional cerebrospinal fluid flow within the human ventricular system. Computer Methods in Biomechanics and Biomedical Engineering. 11(2), 123-133

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