Falcone, Franco - University of Nottingham

个人简介

Dr Franco Falcone received a Degree in Biochemistry (Dipl.-Biochem.) from the University of Tübingen in 1991, and a Degree in Biology (Dipl.-Biol.), also from the University of Tübingen in 1993. He then moved further North to work with Dr Helmut Haas and received a PhD (Dr. rer. nat.) in Immunology from the University of Lübeck in 1996. The PhD thesis received two scientific awards (Best Doctoral Thesis of the Year 2006). After working as a Postdoctoral Research Fellow in the Research Centre Borstel, Germany, he obtained a Fellowship from the Deutsche Forschungsgemeinschaft (DFG) which took him to Edinburgh University (Prof. R. M. Maizels, Prof. A. G. Rossi and Prof. J. E. Allen). He worked as a Scientific Manager of the Association of Clinical Research Centers in Münster, Germany (2001-2003), before returning to a research career with a Wellcome Trust Research Career Development Fellowship which took him to Nottingham, where he has been working since.

研究领域

I am interested in understanding the role of basophils in innate immunity, immunity to parasites and allergy.

近期论文

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METCALFE DD, PAWANKAR R, ACKERMAN SJ, AKIN C, CLAYTON F, FALCONE FH, GLEICH GJ, IRANI AM, JOHANSSON MW, KLION AD, LEIFERMAN KM, LEVI-SCHAFFER F, NILSSON G, OKAYAMA Y, PRUSSIN C, SCHROEDER JT, SCHWARTZ LB, SIMON HU, WALLS AF and TRIGGIANI M, 2016. Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases. The World Allergy Organization journal. 9, 7 HAGE N, RENSHAW JG, WINKLER GS, GELLERT P, STOLNIK S and FALCONE FH, 2015. Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag. Protein expression and purification. 106, 25-30 HAGE N, HOWARD T, PHILLIPS C, BRASSINGTON C, OVERMAN R, DEBRECZENI J, GELLERT P, STOLNIK S, WINKLER GS and FALCONE FH, 2015. Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA. Science Advances. 1(7), e1500315 FALCONE FH, ALCOCER MJ, OKAMOTO-UCHIDA Y and NAKAMURA R, 2015. Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal? Current allergy and asthma reports. 15(11), 67 WADELIN FR, FULTON J, COLLINS HM, TERTIPIS N, BOTTLEY A, SPRIGGS KA, FALCONE FH and HEERY DM, 2015. Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs. PloS one. 10(6), e0129297 VLLASALIU D, FALCONE FH, STOLNIK S and GARNETT M, 2014. Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules. Experimental cell research. 323(1), 218-31 GILICZE AB, WIENER Z, TÓTH S, BUZÁS E, PÁLLINGER E, FALCONE FH and FALUS A, 2014. Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid Regulation. BioMed research international. 2014, 870267 SIEBENHAAR F, FALCONE FH, TILIGADA E, HAMMEL I, MAURER M, SAGI-EISENBERG R and LEVI-SCHAFFER F, 2014. The search for Mast Cell and Basophil models - Are we getting closer to pathophysiological relevance? Allergy. 70(1), 1-5 WAN D, WANG X, NAKAMURA R, ALCOCER MJC and FALCONE FH, 2014. Use of Humanized Rat Basophil Leukemia (RBL) Reporter Systems for Detection of Allergen-Specific IgE Sensitization in Human Serum. Methods in molecular biology (Clifton, N.J.). 1192, 177-84 FALCONE FH and GIBBS BF, 2014. Purification of basophils from peripheral human blood. Methods in molecular biology (Clifton, N.J.). 1192, 35-47 SABATO V, BOITA M, SHUBBER S, BRIDTS CH, SHIBUYA A, DE CLERCK LS, FALCONE FH and EBO DG, 2014. Mechanism of phosphatidylserine inhibition of IgE/FcεRI-dependent anaphylactic human basophil degranulation via CD300a. The Journal of allergy and clinical immunology. 134(3), 734-737.e3 LUDOLF F, PATROCÍNIO PR, CORRÊA-OLIVEIRA R, GAZZINELLI A, FALCONE FH, TEIXEIRA-FERREIRA A, PERALES J, OLIVEIRA GC and SILVA-PEREIRA RA, 2014. Serological screening of the Schistosoma mansoni adult worm proteome. PLoS neglected tropical diseases. 8(3), e2745